SLFN12 — 86 ClinVar variants
All ClinVar germline SLFN12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
10 Likely benign · 76 Uncertain significance
Full SLFN12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLFN12 p.Ala142Val Uncertain significance Single submitter
- SLFN12 p.Ala304Glu Uncertain significance Single submitter
- SLFN12 p.Ala313Ser Uncertain significance Single submitter
- SLFN12 p.Arg155Gly Uncertain significance Single submitter
- SLFN12 p.Arg192Gln Uncertain significance Single submitter
- SLFN12 p.Arg309Ser Uncertain significance Single submitter
- SLFN12 p.Arg334Gly Uncertain significance Single submitter
- SLFN12 p.Arg426Ser Uncertain significance Single submitter
- SLFN12 p.Arg575Pro Uncertain significance Single submitter
- SLFN12 p.Asn360His Uncertain significance Single submitter
- SLFN12 p.Asn65Ser Uncertain significance Single submitter
- SLFN12 p.Asp191Gly Uncertain significance Single submitter
- SLFN12 p.Asp561Val Uncertain significance Single submitter
- SLFN12 p.Cys277Phe Uncertain significance Single submitter
- SLFN12 p.Cys299Gly Uncertain significance Single submitter
- SLFN12 p.Cys312Tyr Uncertain significance Single submitter
- SLFN12 p.Glu220Gln Uncertain significance Single submitter
- SLFN12 p.Glu279Gln Uncertain significance Single submitter
- SLFN12 p.Glu308Gln Uncertain significance Single submitter
- SLFN12 p.Glu318Lys Uncertain significance Single submitter
- SLFN12 p.Glu354Ala Uncertain significance Single submitter
- SLFN12 p.Glu8Lys Uncertain significance Single submitter
- SLFN12 p.Gly235Glu Uncertain significance Single submitter
- SLFN12 p.Ile131Thr Uncertain significance Single submitter
- SLFN12 p.Ile131Val Uncertain significance Single submitter
- SLFN12 p.Ile239Val Uncertain significance Single submitter
- SLFN12 p.Ile268Val Uncertain significance Single submitter
- SLFN12 p.Ile558Met Uncertain significance Single submitter
- SLFN12 p.Ile75Met Uncertain significance Single submitter
- SLFN12 p.Leu126Met Uncertain significance Single submitter
- SLFN12 p.Leu156Phe Uncertain significance Single submitter
- SLFN12 p.Leu530Phe Uncertain significance Single submitter
- SLFN12 p.Leu77Ile Uncertain significance Single submitter
- SLFN12 p.Lys150Asn Uncertain significance Single submitter
- SLFN12 p.Lys151Gln Uncertain significance Single submitter
- SLFN12 p.Lys213Asn Uncertain significance Single submitter
- SLFN12 p.Lys32Met Uncertain significance Single submitter
- SLFN12 p.Lys335Asn Uncertain significance Single submitter
- SLFN12 p.Lys35Asn Uncertain significance Single submitter
- SLFN12 p.Met278Val Uncertain significance Single submitter
- SLFN12 p.Phe466Ile Uncertain significance Single submitter
- SLFN12 p.Phe466Ser Uncertain significance Single submitter
- SLFN12 p.Phe535Ser Uncertain significance Single submitter
- SLFN12 p.Phe550Leu Uncertain significance Single submitter
- SLFN12 p.Phe83Cys Uncertain significance Single submitter
- SLFN12 p.Pro167Leu Uncertain significance Single submitter
- SLFN12 p.Pro382Leu Uncertain significance Single submitter
- SLFN12 p.Ser210Leu Uncertain significance Single submitter
- SLFN12 p.Ser255Arg Uncertain significance Single submitter
- SLFN12 p.Ser27Thr Uncertain significance Single submitter
- SLFN12 p.Ser451Gly Uncertain significance Single submitter
- SLFN12 p.Ser4Ile Uncertain significance Single submitter
- SLFN12 p.Ser69Ile Uncertain significance Single submitter
- SLFN12 p.Thr389Met Uncertain significance Single submitter
- SLFN12 p.Thr476Ala Uncertain significance Single submitter
- SLFN12 p.Thr488Ala Uncertain significance Single submitter
- SLFN12 p.Thr578Ile Uncertain significance Single submitter
- SLFN12 p.Thr9Arg Uncertain significance Single submitter
- SLFN12 p.Tyr225His Uncertain significance Single submitter
- SLFN12 p.Val461Ala Uncertain significance Single submitter
- SLFN12 p.Val58Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- SLFN12 p.Ala230Val Uncertain significance Single submitter
- SLFN12 p.Arg328Pro Uncertain significance Single submitter
- SLFN12 p.Arg46Pro Uncertain significance Single submitter
- SLFN12 p.Asn53Ser Uncertain significance Single submitter
- SLFN12 p.Gln40His Uncertain significance Single submitter
- SLFN12 p.Gly100Ala Uncertain significance Single submitter
- SLFN12 p.Gly100Val Uncertain significance Single submitter
- SLFN12 p.Ile264Thr Uncertain significance Single submitter
- SLFN12 p.Leu87Arg Uncertain significance Single submitter
- SLFN12 p.Pro392Ala Uncertain significance Single submitter
- SLFN12 p.Pro519Leu Uncertain significance Single submitter
- SLFN12 p.Thr199Ile Uncertain significance Single submitter
- SLFN12 p.Thr457Ile Uncertain significance Single submitter
- SLFN12 p.Val21Asp Uncertain significance Single submitter
- SLFN12 p.Val58Ala Uncertain significance Single submitter
All SLFN12 variants
Likely benign 10
- p.Ala537Val Single submitter
- p.Arg269Lys Single submitter
- p.Arg376Gln Single submitter
- p.Leu401Ser Single submitter
- p.Met149Thr Single submitter
- p.Met254Lys Single submitter
- p.Met505Lys Single submitter
- p.Ser45Leu Single submitter
- p.Thr361Met Single submitter
- p.Val430Leu Single submitter
Uncertain significance 76
- p.Ala142Val Single submitter ⚠
- p.Ala230Val Single submitter ⚠
- p.Ala304Glu Single submitter ⚠
- p.Ala313Ser Single submitter ⚠
- p.Arg155Gly Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg309Ser Single submitter ⚠
- p.Arg328Pro Single submitter ⚠
- p.Arg334Gly Single submitter ⚠
- p.Arg426Ser Single submitter ⚠
- p.Arg46Pro Single submitter ⚠
- p.Arg575Pro Single submitter ⚠
- p.Asn360His Single submitter ⚠
- p.Asn53Ser Single submitter ⚠
- p.Asn65Ser Single submitter ⚠
- p.Asp191Gly Single submitter ⚠
- p.Asp561Val Single submitter ⚠
- p.Cys277Phe Single submitter ⚠
- p.Cys299Gly Single submitter ⚠
- p.Cys312Tyr Single submitter ⚠
- p.Gln40His Single submitter ⚠
- p.Glu220Gln Single submitter ⚠
- p.Glu279Gln Single submitter ⚠
- p.Glu308Gln Single submitter ⚠
- p.Glu318Lys Single submitter ⚠
- p.Glu354Ala Single submitter ⚠
- p.Glu8Lys Single submitter ⚠
- p.Gly100Ala Single submitter ⚠
- p.Gly100Val Single submitter ⚠
- p.Gly235Glu Single submitter ⚠
- p.Ile131Thr Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile239Val Single submitter ⚠
- p.Ile264Thr Single submitter ⚠
- p.Ile268Val Single submitter ⚠
- p.Ile558Met Single submitter ⚠
- p.Ile75Met Single submitter ⚠
- p.Leu126Met Single submitter ⚠
- p.Leu156Phe Single submitter ⚠
- p.Leu530Phe Single submitter ⚠
- p.Leu77Ile Single submitter ⚠
- p.Leu87Arg Single submitter ⚠
- p.Lys150Asn Single submitter ⚠
- p.Lys151Gln Single submitter ⚠
- p.Lys213Asn Single submitter ⚠
- p.Lys32Met Single submitter ⚠
- p.Lys335Asn Single submitter ⚠
- p.Lys35Asn Single submitter ⚠
- p.Met278Val Single submitter ⚠
- p.Phe466Ile Single submitter ⚠
- p.Phe466Ser Single submitter ⚠
- p.Phe535Ser Single submitter ⚠
- p.Phe550Leu Single submitter ⚠
- p.Phe83Cys Single submitter ⚠
- p.Pro167Leu Single submitter ⚠
- p.Pro382Leu Single submitter ⚠
- p.Pro392Ala Single submitter ⚠
- p.Pro519Leu Single submitter ⚠
- p.Ser210Leu Single submitter ⚠
- p.Ser255Arg Single submitter ⚠
- p.Ser27Thr Single submitter ⚠
- p.Ser451Gly Single submitter ⚠
- p.Ser4Ile Single submitter ⚠
- p.Ser69Ile Single submitter ⚠
- p.Thr199Ile Single submitter ⚠
- p.Thr389Met Single submitter ⚠
- p.Thr457Ile Single submitter ⚠
- p.Thr476Ala Single submitter ⚠
- p.Thr488Ala Single submitter ⚠
- p.Thr578Ile Single submitter ⚠
- p.Thr9Arg Single submitter ⚠
- p.Tyr225His Single submitter ⚠
- p.Val21Asp Single submitter ⚠
- p.Val461Ala Single submitter ⚠
- p.Val58Ala Single submitter ⚠
- p.Val58Leu Single submitter ⚠