SLK — 137 ClinVar variants

All ClinVar germline SLK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 122 flagged for review →

1 Likely pathogenic · 1 Benign · 8 Likely benign · 127 Uncertain significance

Full SLK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 122

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 102

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 20

The independent predictors disagree with each other — read with care.

All SLK variants

Likely pathogenic 1

p.Glu472Ter Single submitter

Benign 1

p.Ser779Leu Single submitter

Likely benign 8

c.316-8G>T Single submitter
p.Arg369His Single submitter
p.Asn631Ser Single submitter
p.Gly521Glu Single submitter
p.Ile397Val Single submitter
p.Ile495Thr Single submitter
p.Thr569= Single submitter
p.Thr569Ala Single submitter

Uncertain significance 127

p.Ala1109Ser Single submitter ⚠
p.Ala307Val Single submitter ⚠
p.Ala984Ser Single submitter ⚠
p.Arg1068Gly Single submitter ⚠
p.Arg1082Ter Single submitter
p.Arg1091Lys Single submitter ⚠
p.Arg1143Cys Single submitter ⚠
p.Arg1185Trp Single submitter ⚠
p.Arg1220Gln Single submitter ⚠
p.Arg338Leu Single submitter ⚠
p.Arg369Cys Single submitter ⚠
p.Arg787Lys Single submitter ⚠
p.Arg828His Single submitter ⚠
p.Arg832Trp Single submitter ⚠
p.Arg856Gln Single submitter ⚠
p.Arg906Leu Single submitter ⚠
p.Asn1053Ser Single submitter
p.Asn1141Ser Single submitter ⚠
p.Asn276Ser Single submitter ⚠
p.Asn371Lys Single submitter ⚠
p.Asn466Ile Single submitter ⚠
p.Asn512Tyr Single submitter ⚠
p.Asn544Ser Single submitter ⚠
p.Asn572Asp Single submitter ⚠
p.Asn609Ser Single submitter ⚠
p.Asn626Ser Single submitter ⚠
p.Asn716Ser Single submitter ⚠
p.Asn746Asp Single submitter ⚠
p.Asp168Asn Single submitter ⚠
p.Asp168Gly Single submitter
p.Asp168Tyr Single submitter ⚠
p.Asp403Asn Single submitter ⚠
p.Asp443Asn Single submitter ⚠
p.Asp500Tyr Single submitter ⚠
p.Asp568Asn Single submitter ⚠
p.Asp573Asn Single submitter ⚠
p.Asp749Val Single submitter ⚠
p.Cys272Arg Single submitter ⚠
p.Cys358Ser Single submitter ⚠
p.Cys552Arg Single submitter ⚠
p.Gln1123Leu Single submitter ⚠
p.Gln1218Pro Single submitter ⚠
p.Gln405Arg Single submitter ⚠
p.Gln582Glu Single submitter ⚠
p.Gln582His Single submitter ⚠
p.Gln662Arg Single submitter ⚠
p.Gln788Glu Single submitter ⚠
p.Gln894Arg Single submitter ⚠
p.Gln959Lys Single submitter ⚠
p.Gln980Arg Single submitter ⚠
p.Gln998Arg Single submitter ⚠
p.Glu1012Lys Single submitter ⚠
p.Glu122Asp Single submitter ⚠
p.Glu321Asp Single submitter ⚠
p.Glu323Lys Single submitter ⚠
p.Glu407Gly Single submitter ⚠
p.Glu579Lys Single submitter ⚠
p.Glu685Lys Single submitter ⚠
p.Glu693Asp Single submitter ⚠
p.Glu724fs Single submitter
p.Glu784Ala Single submitter
p.Glu893Gln Single submitter ⚠
p.Glu903Lys Single submitter ⚠
p.Gly13Ala Single submitter ⚠
p.Gly13Arg Single submitter ⚠
p.Gly41Asp Single submitter ⚠
p.Gly521Trp Single submitter ⚠
p.Gly973Asp Single submitter ⚠
p.His1159Tyr Single submitter ⚠
p.His235Tyr Single submitter ⚠
p.His957Gln Single submitter ⚠
p.Ile37Thr Single submitter ⚠
p.Ile495Leu Single submitter ⚠
p.Ile513Thr Single submitter ⚠
p.Ile605Thr Single submitter ⚠
p.Ile627Leu Single submitter ⚠
p.Ile715Val Single submitter ⚠
p.Ile726Met Single submitter ⚠
p.Ile735Val Single submitter ⚠
p.Leu1134Val Single submitter ⚠
p.Leu287Met Single submitter ⚠
p.Leu412Ile Single submitter ⚠
p.Lys1176Thr Single submitter ⚠
p.Lys1181Arg Single submitter ⚠
p.Lys1205Asn Single submitter ⚠
p.Lys19Gln Single submitter ⚠
p.Lys366Glu Single submitter ⚠
p.Lys484Glu Single submitter ⚠
p.Lys536Arg Single submitter ⚠
p.Lys674Arg Single submitter ⚠
p.Lys870Glu Single submitter ⚠
p.Lys977Asn Single submitter ⚠
p.Met1033Arg Single submitter ⚠
p.Met480Val Single submitter ⚠
p.Met945Thr Single submitter ⚠
p.Phe963Leu Single submitter ⚠
p.Pro199Leu Single submitter ⚠
p.Pro694Ser Single submitter ⚠
p.Pro707Leu Single submitter ⚠
p.Pro937Thr Single submitter ⚠
p.Ser14Gly Single submitter ⚠
p.Ser330Tyr Single submitter ⚠
p.Ser546Thr Single submitter ⚠
p.Ser565Gly Single submitter ⚠
p.Ser667Gly Single submitter ⚠
p.Ser781Pro Single submitter ⚠
p.Ser850Arg Single submitter ⚠
p.Thr1046Ala Single submitter ⚠
p.Thr128Ser Single submitter ⚠
p.Thr183Ser Single submitter ⚠
p.Thr224Ala Single submitter ⚠
p.Thr254Ala Single submitter ⚠
p.Thr367Ala Single submitter ⚠
p.Thr386Ile Single submitter ⚠
p.Thr498Ile Single submitter ⚠
p.Thr523Lys Single submitter ⚠
p.Thr637Ser Single submitter ⚠
p.Thr648Asn Single submitter ⚠
p.Thr648Ser Single submitter ⚠
p.Thr703Ile Single submitter ⚠
p.Thr732Ala Single submitter ⚠
p.Thr752Pro Single submitter ⚠
p.Thr758Ala Single submitter ⚠
p.Trp261Gly Single submitter ⚠
p.Val363Leu Single submitter ⚠
p.Val502Ile Single submitter ⚠
p.Val561Gly Single submitter ⚠