Sugi Variant

Sugi Variant/SMC5

SMC5 — 128 ClinVar variants

All ClinVar germline SMC5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →

3 Pathogenic · 2 Likely pathogenic · 5 Benign · 7 Likely benign · 111 Uncertain significance

Full SMC5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 109

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 83

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 26

The independent predictors disagree with each other — read with care.

All SMC5 variants

Pathogenic 3

Likely pathogenic 2

Benign 5

Likely benign 7

Uncertain significance 111