SMYD2 — 52 ClinVar variants
All ClinVar germline SMYD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Likely benign · 51 Uncertain significance
Full SMYD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SMYD2 p.Ala197Val Uncertain significance Single submitter
- SMYD2 p.Arg292Gln Uncertain significance Single submitter
- SMYD2 p.Arg2Gly Uncertain significance Single submitter
- SMYD2 p.Arg48Trp Uncertain significance Single submitter
- SMYD2 p.Asn212Ser Uncertain significance Single submitter
- SMYD2 p.Asn300Asp Uncertain significance Single submitter
- SMYD2 p.Asn46Lys Uncertain significance Single submitter
- SMYD2 p.Asn99His Uncertain significance Single submitter
- SMYD2 p.Asp284Asn Uncertain significance Single submitter
- SMYD2 p.Asp284His Uncertain significance Single submitter
- SMYD2 p.Asp334Asn Uncertain significance Single submitter
- SMYD2 p.Gln150Arg Uncertain significance Single submitter
- SMYD2 p.Glu316Asp Uncertain significance Single submitter
- SMYD2 p.Glu322Lys Uncertain significance Single submitter
- SMYD2 p.Glu4Gly Uncertain significance Single submitter
- SMYD2 p.Glu60Lys Uncertain significance Single submitter
- SMYD2 p.Glu98Gly Uncertain significance Single submitter
- SMYD2 p.Gly165Arg Uncertain significance Single submitter
- SMYD2 p.Gly417Ser Uncertain significance Single submitter
- SMYD2 p.His207Asp Uncertain significance Single submitter
- SMYD2 p.Ile367Val Uncertain significance Single submitter
- SMYD2 p.Leu138Pro Uncertain significance Single submitter
- SMYD2 p.Leu376Phe Uncertain significance Single submitter
- SMYD2 p.Lys309Arg Uncertain significance Single submitter
- SMYD2 p.Met384Leu Uncertain significance Single submitter
- SMYD2 p.Met85Val Uncertain significance Single submitter
- SMYD2 p.Phe166Ile Uncertain significance Single submitter
- SMYD2 p.Pro232Arg Uncertain significance Single submitter
- SMYD2 p.Ser330Phe Uncertain significance Single submitter
- SMYD2 p.Ser63Thr Uncertain significance Single submitter
- SMYD2 p.Thr109Ile Uncertain significance Single submitter
- SMYD2 p.Thr247Met Uncertain significance Single submitter
- SMYD2 p.Tyr422Phe Uncertain significance Single submitter
- SMYD2 p.Val76Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- SMYD2 p.Arg253Trp Uncertain significance Single submitter
- SMYD2 p.Arg306Trp Uncertain significance Single submitter
- SMYD2 p.Glu190Lys Uncertain significance Single submitter
- SMYD2 p.His51Asp Uncertain significance Single submitter
- SMYD2 p.Leu172Phe Uncertain significance Single submitter
- SMYD2 p.Met294Arg Uncertain significance Single submitter
- SMYD2 p.Met347Val Uncertain significance Single submitter
- SMYD2 p.Met384Ile Uncertain significance Single submitter
- SMYD2 p.Pro102Leu Uncertain significance Single submitter
- SMYD2 p.Ser136Leu Uncertain significance Single submitter
- SMYD2 p.Tyr422Ser Uncertain significance Single submitter
- SMYD2 p.Val227Leu Uncertain significance Single submitter
- SMYD2 p.Val337Met Uncertain significance Single submitter
- SMYD2 p.Val381Met Uncertain significance Single submitter
All SMYD2 variants
Likely benign 1
- p.Lys398Arg Single submitter
Uncertain significance 51
- p.Ala197Val Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg2Gly Single submitter ⚠
- p.Arg306Trp Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Asn212Ser Single submitter ⚠
- p.Asn300Asp Single submitter ⚠
- p.Asn46Lys Single submitter ⚠
- p.Asn99His Single submitter ⚠
- p.Asp284Asn Single submitter ⚠
- p.Asp284His Single submitter ⚠
- p.Asp334Asn Single submitter ⚠
- p.Gln150Arg Single submitter ⚠
- p.Glu190Lys Single submitter ⚠
- p.Glu316Asp Single submitter ⚠
- p.Glu322Lys Single submitter ⚠
- p.Glu425Lys Single submitter
- p.Glu4Gly Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Glu98Gly Single submitter ⚠
- p.Gly165Arg Single submitter ⚠
- p.Gly417Ser Single submitter ⚠
- p.His207Asp Single submitter ⚠
- p.His51Asp Single submitter ⚠
- p.Ile367Val Single submitter ⚠
- p.Leu138Pro Single submitter ⚠
- p.Leu172Phe Single submitter ⚠
- p.Leu376Phe Single submitter ⚠
- p.Lys309Arg Single submitter ⚠
- p.Met294Arg Single submitter ⚠
- p.Met347Val Single submitter ⚠
- p.Met384Ile Single submitter ⚠
- p.Met384Leu Single submitter ⚠
- p.Met85Val Single submitter ⚠
- p.Phe166Ile Single submitter ⚠
- p.Pro102Leu Single submitter ⚠
- p.Pro232Arg Single submitter ⚠
- p.Ser136Leu Single submitter ⚠
- p.Ser330Phe Single submitter ⚠
- p.Ser63Thr Single submitter ⚠
- p.Thr109Ile Single submitter ⚠
- p.Thr123Ile Single submitter
- p.Thr247Lys Single submitter
- p.Thr247Met Single submitter ⚠
- p.Tyr422Phe Single submitter ⚠
- p.Tyr422Ser Single submitter ⚠
- p.Val227Leu Single submitter ⚠
- p.Val337Met Single submitter ⚠
- p.Val381Met Single submitter ⚠
- p.Val76Met Single submitter ⚠