SMYD3 — 64 ClinVar variants
All ClinVar germline SMYD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
2 Benign · 62 Uncertain significance
Full SMYD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SMYD3 p.Ala168Val Uncertain significance Single submitter
- SMYD3 p.Ala423Thr Uncertain significance Single submitter
- SMYD3 p.Arg227Gln Uncertain significance Single submitter
- SMYD3 p.Arg249His Uncertain significance Single submitter
- SMYD3 p.Arg250Gln Uncertain significance Single submitter
- SMYD3 p.Arg319Gln Uncertain significance Single submitter
- SMYD3 p.Arg61Gln Uncertain significance Single submitter
- SMYD3 p.Arg66Cys Uncertain significance Single submitter
- SMYD3 p.Arg66His Uncertain significance Single submitter
- SMYD3 p.Asn132Ser Uncertain significance Single submitter
- SMYD3 p.Asn217Ser Uncertain significance Single submitter
- SMYD3 p.Asp128Tyr Uncertain significance Single submitter
- SMYD3 p.Asp139Ala Uncertain significance Single submitter
- SMYD3 p.Asp139Gly Uncertain significance Single submitter
- SMYD3 p.Asp270Gly Uncertain significance Single submitter
- SMYD3 p.Asp422Asn Uncertain significance Single submitter
- SMYD3 p.Cys238Ser Uncertain significance Single submitter
- SMYD3 p.Cys263Arg Uncertain significance Single submitter
- SMYD3 p.Cys89Tyr Uncertain significance Single submitter
- SMYD3 p.Gln191Arg Uncertain significance Single submitter
- SMYD3 p.Glu121Asp Uncertain significance Single submitter
- SMYD3 p.Glu230Lys Uncertain significance Single submitter
- SMYD3 p.Glu285Asp Uncertain significance Single submitter
- SMYD3 p.Glu57Val Uncertain significance Single submitter
- SMYD3 p.Ile293Met Uncertain significance Single submitter
- SMYD3 p.Ile411Thr Uncertain significance Single submitter
- SMYD3 p.Ile415Val Uncertain significance Single submitter
- SMYD3 p.Leu123Val Uncertain significance Single submitter
- SMYD3 p.Leu379Pro Uncertain significance Single submitter
- SMYD3 p.Lys297Gln Uncertain significance Single submitter
- SMYD3 p.Lys84Arg Uncertain significance Single submitter
- SMYD3 p.Lys94Thr Uncertain significance Single submitter
- SMYD3 p.Met155Val Uncertain significance Single submitter
- SMYD3 p.Met390Val Uncertain significance Single submitter
- SMYD3 p.Met60Thr Uncertain significance Single submitter
- SMYD3 p.Phe264Cys Uncertain significance Single submitter
- SMYD3 p.Pro23Ser Uncertain significance Single submitter
- SMYD3 p.Ser101Thr Uncertain significance Single submitter
- SMYD3 p.Ser125Ala Uncertain significance Single submitter
- SMYD3 p.Ser213Leu Uncertain significance Single submitter
- SMYD3 p.Ser33Leu Uncertain significance Single submitter
- SMYD3 p.Ser92Ile Uncertain significance Single submitter
- SMYD3 p.Val148Ile Uncertain significance Single submitter
- SMYD3 p.Val48Ile Uncertain significance Single submitter
- SMYD3 p.Val67Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- SMYD3 p.Ala389Thr Uncertain significance Single submitter
- SMYD3 p.Arg103Gln Uncertain significance Single submitter
- SMYD3 p.Arg224Gln Uncertain significance Single submitter
- SMYD3 p.Arg227Gly Uncertain significance Single submitter
- SMYD3 p.Asp100His Uncertain significance Single submitter
- SMYD3 p.Cys258Gly Uncertain significance Single submitter
- SMYD3 p.Gln64His Uncertain significance Single submitter
- SMYD3 p.Ile237Phe Uncertain significance Single submitter
- SMYD3 p.Ile293Thr Uncertain significance Single submitter
- SMYD3 p.Leu30Phe Uncertain significance Single submitter
- SMYD3 p.Lys329Thr Uncertain significance Single submitter
- SMYD3 p.Phe362Ile Uncertain significance Single submitter
- SMYD3 p.Tyr239His Uncertain significance Single submitter
- SMYD3 p.Val178Ala Uncertain significance Single submitter
All SMYD3 variants
Benign 2
- c.813+8G>A Multiple submitters
- p.Val67= Multiple submitters
Uncertain significance 62
- p.Ala168Val Single submitter ⚠
- p.Ala20Val Single submitter
- p.Ala389Thr Single submitter ⚠
- p.Ala423Thr Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg103Ter Single submitter
- p.Arg19His Single submitter
- p.Arg224Gln Single submitter ⚠
- p.Arg227Gln Single submitter ⚠
- p.Arg227Gly Single submitter ⚠
- p.Arg249His Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg319Gln Single submitter ⚠
- p.Arg61Gln Single submitter ⚠
- p.Arg66Cys Single submitter ⚠
- p.Arg66His Single submitter ⚠
- p.Asn132Ser Single submitter ⚠
- p.Asn217Ser Single submitter ⚠
- p.Asp100His Single submitter ⚠
- p.Asp128Tyr Single submitter ⚠
- p.Asp139Ala Single submitter ⚠
- p.Asp139Gly Single submitter ⚠
- p.Asp270Gly Single submitter ⚠
- p.Asp422Asn Single submitter ⚠
- p.Cys238Ser Single submitter ⚠
- p.Cys258Gly Single submitter ⚠
- p.Cys263Arg Single submitter ⚠
- p.Cys89Tyr Single submitter ⚠
- p.Gln191Arg Single submitter ⚠
- p.Gln64His Single submitter ⚠
- p.Glu121Asp Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Glu285Asp Single submitter ⚠
- p.Glu57Val Single submitter ⚠
- p.Ile237Phe Single submitter ⚠
- p.Ile293Met Single submitter ⚠
- p.Ile293Thr Single submitter ⚠
- p.Ile411Thr Single submitter ⚠
- p.Ile415Val Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Leu30Phe Single submitter ⚠
- p.Leu379Pro Single submitter ⚠
- p.Lys297Gln Single submitter ⚠
- p.Lys329Thr Single submitter ⚠
- p.Lys84Arg Single submitter ⚠
- p.Lys94Thr Single submitter ⚠
- p.Met155Val Single submitter ⚠
- p.Met390Val Single submitter ⚠
- p.Met60Thr Single submitter ⚠
- p.Phe264Cys Single submitter ⚠
- p.Phe362Ile Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Ser101Thr Single submitter ⚠
- p.Ser125Ala Single submitter ⚠
- p.Ser213Leu Single submitter ⚠
- p.Ser33Leu Single submitter ⚠
- p.Ser92Ile Single submitter ⚠
- p.Tyr239His Single submitter ⚠
- p.Val148Ile Single submitter ⚠
- p.Val178Ala Single submitter ⚠
- p.Val48Ile Single submitter ⚠
- p.Val67Ile Single submitter ⚠