SNCAIP — 193 ClinVar variants
All ClinVar germline SNCAIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 114 flagged for review →
2 Conflicting · 8 Benign · 6 Benign/Likely benign · 35 Likely benign · 142 Uncertain significance
Full SNCAIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 114
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
SNCAIP p.Ala714Thr
Conflicting
Single submitter
Parkinson Disease, Dominant/Recessive
-
SNCAIP p.Arg731Cys
Conflicting
Single submitter
Parkinson Disease, Dominant/Recessive
Predictors lean, ClinVar uncertain 91
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SNCAIP p.Ala358Val Uncertain significance Multiple submitters
-
SNCAIP p.Ala363Thr
Uncertain significance
Multiple submitters
Parkinson Disease, Dominant/Recessive
-
SNCAIP p.Glu237Lys
Uncertain significance
Multiple submitters
Parkinson Disease, Dominant/Recessive
-
SNCAIP p.Ser912Arg
Uncertain significance
Multiple submitters
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Val461Ile Uncertain significance Multiple submitters
- SNCAIP p.Ala3Thr Uncertain significance Single submitter
- SNCAIP p.Ala489Thr Uncertain significance Single submitter
-
SNCAIP p.Ala647Pro
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Ala696Val Uncertain significance Single submitter
- SNCAIP p.Ala863Gly Uncertain significance Single submitter
- SNCAIP p.Ala911Ser Uncertain significance Single submitter
- SNCAIP p.Arg303Gln Uncertain significance Single submitter
- SNCAIP p.Arg33Gln Uncertain significance Single submitter
-
SNCAIP p.Arg499Gln
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Arg536Cys Uncertain significance Single submitter
-
SNCAIP p.Arg606Gln
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Arg606Trp Uncertain significance Single submitter
- SNCAIP p.Arg621His Uncertain significance Single submitter
- SNCAIP p.Arg698Gln Uncertain significance Single submitter
- SNCAIP p.Arg807Lys Uncertain significance Single submitter
- SNCAIP p.Asn203Ile Uncertain significance Single submitter
- SNCAIP p.Asn50Lys Uncertain significance Single submitter
- SNCAIP p.Asn683Ser Uncertain significance Single submitter
- SNCAIP p.Asn91Ser Uncertain significance Single submitter
- SNCAIP p.Asp41Gly Uncertain significance Single submitter
- SNCAIP p.Asp96Asn Uncertain significance Single submitter
- SNCAIP p.Cys35Tyr Uncertain significance Single submitter
- SNCAIP p.Gln100Lys Uncertain significance Single submitter
- SNCAIP p.Gln279His Uncertain significance Single submitter
- SNCAIP p.Gln38Pro Uncertain significance Single submitter
- SNCAIP p.Gln545Arg Uncertain significance Single submitter
- SNCAIP p.Gln762Pro Uncertain significance Single submitter
- SNCAIP p.Glu310Gln Uncertain significance Single submitter
- SNCAIP p.Glu433Gly Uncertain significance Single submitter
- SNCAIP p.Glu491Gln Uncertain significance Single submitter
- SNCAIP p.Glu548Lys Uncertain significance Single submitter
- SNCAIP p.Glu630Asp Uncertain significance Single submitter
- SNCAIP p.Glu630Gly Uncertain significance Single submitter
- SNCAIP p.Glu753Gln Uncertain significance Single submitter
- SNCAIP p.Glu831Gln Uncertain significance Single submitter
- SNCAIP p.Glu87Asp Uncertain significance Single submitter
- SNCAIP p.Gly109Asp Uncertain significance Single submitter
- SNCAIP p.Gly114Asp Uncertain significance Single submitter
- SNCAIP p.Gly128Ser Uncertain significance Single submitter
- SNCAIP p.Gly776Arg Uncertain significance Single submitter
- SNCAIP p.Gly834Ala Uncertain significance Single submitter
- SNCAIP p.Gly905Arg Uncertain significance Single submitter
- SNCAIP p.His267Arg Uncertain significance Single submitter
- SNCAIP p.His467Arg Uncertain significance Single submitter
- SNCAIP p.Ile177Asn Uncertain significance Single submitter
- SNCAIP p.Leu178Trp Uncertain significance Single submitter
- SNCAIP p.Leu285Val Uncertain significance Single submitter
- SNCAIP p.Leu56Phe Uncertain significance Single submitter
- SNCAIP p.Leu662Pro Uncertain significance Single submitter
- SNCAIP p.Leu726Met Uncertain significance Single submitter
- SNCAIP p.Lys101Arg Uncertain significance Single submitter
-
SNCAIP p.Lys230Glu
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Lys244Glu Uncertain significance Single submitter
- SNCAIP p.Lys261Gln Uncertain significance Single submitter
- SNCAIP p.Lys575Thr Uncertain significance Single submitter
- SNCAIP p.Lys77Arg Uncertain significance Single submitter
- SNCAIP p.Lys836Arg Uncertain significance Single submitter
- SNCAIP p.Lys858Arg Uncertain significance Single submitter
-
SNCAIP p.Lys98Glu
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Met720Leu Uncertain significance Single submitter
- SNCAIP p.Phe168Tyr Uncertain significance Single submitter
- SNCAIP p.Phe263Cys Uncertain significance Single submitter
- SNCAIP p.Pro122Leu Uncertain significance Single submitter
-
SNCAIP p.Pro130Ser
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Pro206Ser Uncertain significance Single submitter
- SNCAIP p.Pro828Ala Uncertain significance Single submitter
- SNCAIP p.Ser137Gly Uncertain significance Single submitter
- SNCAIP p.Ser200Pro Uncertain significance Single submitter
-
SNCAIP p.Ser46Asn
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Ser506Cys Uncertain significance Single submitter
- SNCAIP p.Ser552Ala Uncertain significance Single submitter
- SNCAIP p.Ser566Leu Uncertain significance Single submitter
- SNCAIP p.Ser600Asn Uncertain significance Single submitter
-
SNCAIP p.Ser604Cys
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Ser707Arg Uncertain significance Single submitter
- SNCAIP p.Ser710Asn Uncertain significance Single submitter
- SNCAIP p.Ser716Asn Uncertain significance Single submitter
- SNCAIP p.Ser761Thr Uncertain significance Single submitter
- SNCAIP p.Ser766Leu Uncertain significance Single submitter
- SNCAIP p.Ser775Phe Uncertain significance Single submitter
- SNCAIP p.Thr262Ile Uncertain significance Single submitter
- SNCAIP p.Thr37Met Uncertain significance Single submitter
- SNCAIP p.Thr64Ser Uncertain significance Single submitter
- SNCAIP p.Thr691Ile Uncertain significance Single submitter
- SNCAIP p.Val453Ala Uncertain significance Single submitter
-
SNCAIP p.Val483Ala
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
Predictors split 21
The independent predictors disagree with each other — read with care.
- SNCAIP p.Phe73Leu Likely benign Multiple submitters
- SNCAIP p.Ala392Gly Uncertain significance Single submitter
- SNCAIP p.Ala427Ser Uncertain significance Single submitter
- SNCAIP p.Arg846Trp Uncertain significance Single submitter
- SNCAIP p.Arg899Thr Uncertain significance Single submitter
- SNCAIP p.Asp149Gly Uncertain significance Single submitter
- SNCAIP p.Gly141Arg Uncertain significance Single submitter
-
SNCAIP p.Gly873Asp
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Ile411Thr Uncertain significance Single submitter
- SNCAIP p.Leu316Pro Uncertain significance Single submitter
- SNCAIP p.Leu638Pro Uncertain significance Single submitter
- SNCAIP p.Leu799Phe Uncertain significance Single submitter
- SNCAIP p.Lys722Glu Uncertain significance Single submitter
- SNCAIP p.Met373Thr Uncertain significance Single submitter
- SNCAIP p.Phe14Val Uncertain significance Single submitter
- SNCAIP p.Phe864Cys Uncertain significance Single submitter
- SNCAIP p.Pro4Thr Uncertain significance Single submitter
- SNCAIP p.Ser15Asn Uncertain significance Single submitter
- SNCAIP p.Ser716Arg Uncertain significance Single submitter
-
SNCAIP p.Ser910Tyr
Uncertain significance
Single submitter
Parkinson Disease, Dominant/Recessive
- SNCAIP p.Val512Met Uncertain significance Single submitter
All SNCAIP variants
Conflicting classifications of pathogenicity 2
- p.Ala714Thr Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Arg731Cys Single submitter Parkinson Disease, Dominant/Recessive ⚠
Benign 8
- p.Arg806His Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Met711Val Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Ser406= Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Thr27= Multiple submitters Parkinson Disease, Dominant/Recessive
- c.-49C>G Single submitter Parkinson Disease, Dominant/Recessive
- c.*314T>C Single submitter Parkinson Disease, Dominant/Recessive
- p.Lys575= Single submitter
- p.Val816= Single submitter
Benign/Likely benign 6
- c.*70C>G Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Cys192= Multiple submitters
- p.Glu709Gln Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Leu378= Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Pro212= Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Ser139= Multiple submitters Parkinson Disease, Dominant/Recessive
Likely benign 35
- c.*102A>G Multiple submitters Parkinson Disease, Dominant/Recessive
- c.*103C>T Multiple submitters Parkinson Disease, Dominant/Recessive
- c.*46T>G Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Arg621Cys Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Asn203Ser Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Gly390= Multiple submitters
- p.Leu504= Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Phe73Leu Multiple submitters ⚠
- p.Ser222Leu Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Thr37= Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Val224= Multiple submitters Parkinson Disease, Dominant/Recessive
- c.-26G>A Single submitter Parkinson Disease, Dominant/Recessive
- c.*253T>A Single submitter Parkinson Disease, Dominant/Recessive
- p.Ala497= Single submitter
- p.Ala739= Single submitter
- p.Ala911Thr Single submitter
- p.Arg269Gln Single submitter Parkinson Disease, Dominant/Recessive
- p.Arg303Trp Single submitter
- p.Cys245= Single submitter
- p.Gly127= Single submitter
- p.Gly554Asp Single submitter
- p.Ile424= Single submitter
- p.Ile53Val Single submitter
- p.Leu717= Single submitter
- p.Lys317= Single submitter
- p.Lys738= Single submitter
- p.Pro701= Single submitter
- p.Pro764Leu Single submitter Parkinson Disease, Dominant/Recessive
- p.Pro86= Single submitter Parkinson Disease, Dominant/Recessive
- p.Ser716= Single submitter Parkinson Disease, Dominant/Recessive
- p.Ser755= Single submitter
- p.Ser80= Single submitter
- p.Ser853= Single submitter
- p.Thr236= Single submitter Parkinson Disease, Dominant/Recessive
- p.Tyr146= Single submitter
Uncertain significance 142
- p.Ala358Val Multiple submitters ⚠
- p.Ala363Thr Multiple submitters Parkinson Disease, Dominant/Recessive ⚠
- p.Glu237Lys Multiple submitters Parkinson Disease, Dominant/Recessive ⚠
- p.Leu148= Multiple submitters Parkinson Disease, Dominant/Recessive
- p.Ser912Arg Multiple submitters Parkinson Disease, Dominant/Recessive ⚠
- p.Val461Ile Multiple submitters ⚠
- c.1002+2T>C Single submitter Parkinson Disease, Dominant/Recessive
- c.1002+7A>G Single submitter Parkinson Disease, Dominant/Recessive
- c.1297-3T>C Single submitter Parkinson Disease, Dominant/Recessive
- c.-13G>T Single submitter Parkinson Disease, Dominant/Recessive
- c.-46-6G>A Single submitter Parkinson Disease, Dominant/Recessive
- c.-47+3G>A Single submitter Parkinson Disease, Dominant/Recessive
- c.-48G>A Single submitter Parkinson Disease, Dominant/Recessive
- c.-54C>A Single submitter Parkinson Disease, Dominant/Recessive
- c.-66C>T Single submitter Parkinson Disease, Dominant/Recessive
- c.*161A>G Single submitter Parkinson Disease, Dominant/Recessive
- c.*170A>G Single submitter Parkinson Disease, Dominant/Recessive
- c.*202A>T Single submitter Parkinson Disease, Dominant/Recessive
- c.*247G>A Single submitter Parkinson Disease, Dominant/Recessive
- c.*287G>A Single submitter Parkinson Disease, Dominant/Recessive
- c.*343A>G Single submitter Parkinson Disease, Dominant/Recessive
- c.*498A>G Single submitter Parkinson Disease, Dominant/Recessive
- c.*591A>T Single submitter Parkinson Disease, Dominant/Recessive
- p.Ala392Gly Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Ala427Ser Single submitter ⚠
- p.Ala489Thr Single submitter ⚠
- p.Ala647Pro Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Ala696Val Single submitter ⚠
- p.Ala863Gly Single submitter ⚠
- p.Ala911Ser Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg402= Single submitter Parkinson Disease, Dominant/Recessive
- p.Arg499Gln Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Arg536Cys Single submitter ⚠
- p.Arg606Gln Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Arg606Trp Single submitter ⚠
- p.Arg621His Single submitter ⚠
- p.Arg698Gln Single submitter ⚠
- p.Arg807Lys Single submitter ⚠
- p.Arg846Trp Single submitter ⚠
- p.Arg865Gln Single submitter
- p.Arg899Thr Single submitter ⚠
- p.Asn203Ile Single submitter ⚠
- p.Asn50Lys Single submitter ⚠
- p.Asn683Ser Single submitter ⚠
- p.Asn91Ser Single submitter ⚠
- p.Asp149Gly Single submitter ⚠
- p.Asp41Gly Single submitter ⚠
- p.Asp68= Single submitter Parkinson Disease, Dominant/Recessive
- p.Asp96Asn Single submitter ⚠
- p.Cys35Tyr Single submitter ⚠
- p.Gln100Lys Single submitter ⚠
- p.Gln279His Single submitter ⚠
- p.Gln38Pro Single submitter ⚠
- p.Gln545Arg Single submitter ⚠
- p.Gln669Pro Single submitter
- p.Gln762Pro Single submitter ⚠
- p.Glu310Gln Single submitter ⚠
- p.Glu433Gly Single submitter ⚠
- p.Glu491Gln Single submitter ⚠
- p.Glu548Lys Single submitter ⚠
- p.Glu630Asp Single submitter ⚠
- p.Glu630Gly Single submitter ⚠
- p.Glu753Gln Single submitter ⚠
- p.Glu831Gln Single submitter ⚠
- p.Glu852= Single submitter Parkinson Disease, Dominant/Recessive
- p.Glu87Asp Single submitter ⚠
- p.Gly109Asp Single submitter ⚠
- p.Gly114Asp Single submitter ⚠
- p.Gly128Ser Single submitter ⚠
- p.Gly141Arg Single submitter ⚠
- p.Gly776Arg Single submitter ⚠
- p.Gly834Ala Single submitter ⚠
- p.Gly873Asp Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Gly905Arg Single submitter ⚠
- p.His267Arg Single submitter ⚠
- p.His467Arg Single submitter ⚠
- p.Ile177Asn Single submitter ⚠
- p.Ile325Thr Single submitter
- p.Ile411Thr Single submitter ⚠
- p.Ile66= Single submitter Parkinson Disease, Dominant/Recessive
- p.Leu143= Single submitter Parkinson Disease, Dominant/Recessive
- p.Leu178Trp Single submitter ⚠
- p.Leu285Val Single submitter ⚠
- p.Leu316Pro Single submitter ⚠
- p.Leu56Phe Single submitter ⚠
- p.Leu638Pro Single submitter ⚠
- p.Leu657= Single submitter Parkinson Disease, Dominant/Recessive
- p.Leu662Pro Single submitter ⚠
- p.Leu726Met Single submitter ⚠
- p.Leu799Phe Single submitter ⚠
- p.Lys101Arg Single submitter ⚠
- p.Lys230Glu Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Lys244Glu Single submitter ⚠
- p.Lys261Gln Single submitter ⚠
- p.Lys524Arg Single submitter
- p.Lys575Thr Single submitter ⚠
- p.Lys722Glu Single submitter ⚠
- p.Lys77Arg Single submitter ⚠
- p.Lys836Arg Single submitter ⚠
- p.Lys858Arg Single submitter ⚠
- p.Lys98Glu Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Met373Thr Single submitter ⚠
- p.Met720Leu Single submitter ⚠
- p.Phe14Val Single submitter ⚠
- p.Phe168Tyr Single submitter ⚠
- p.Phe263Cys Single submitter ⚠
- p.Phe864Cys Single submitter ⚠
- p.Pro122Leu Single submitter ⚠
- p.Pro130Ser Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Pro206Ser Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Pro828Ala Single submitter ⚠
- p.Ser137Gly Single submitter ⚠
- p.Ser15Asn Single submitter ⚠
- p.Ser200Pro Single submitter ⚠
- p.Ser46Asn Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Ser506Cys Single submitter ⚠
- p.Ser552Ala Single submitter ⚠
- p.Ser566Leu Single submitter ⚠
- p.Ser600Asn Single submitter ⚠
- p.Ser604Cys Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Ser674= Single submitter Parkinson Disease, Dominant/Recessive
- p.Ser707Arg Single submitter ⚠
- p.Ser710Asn Single submitter ⚠
- p.Ser716Arg Single submitter ⚠
- p.Ser716Asn Single submitter ⚠
- p.Ser761Thr Single submitter ⚠
- p.Ser766Leu Single submitter ⚠
- p.Ser775Phe Single submitter ⚠
- p.Ser910Tyr Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Thr262= Single submitter Parkinson Disease, Dominant/Recessive
- p.Thr262Ile Single submitter ⚠
- p.Thr37Met Single submitter ⚠
- p.Thr64Ser Single submitter ⚠
- p.Thr691Ile Single submitter ⚠
- p.Thr895= Single submitter Parkinson Disease, Dominant/Recessive
- p.Val453Ala Single submitter ⚠
- p.Val483Ala Single submitter Parkinson Disease, Dominant/Recessive ⚠
- p.Val512Met Single submitter ⚠