SNRPA1 — 25 ClinVar variants
All ClinVar germline SNRPA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
25 Uncertain significance
Full SNRPA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SNRPA1 p.Arg234His Uncertain significance Single submitter
- SNRPA1 p.Arg78Cys Uncertain significance Single submitter
- SNRPA1 p.Asp190Gly Uncertain significance Single submitter
- SNRPA1 p.Asp200Glu Uncertain significance Single submitter
- SNRPA1 p.Asp249Gly Uncertain significance Single submitter
- SNRPA1 p.Asp58Val Uncertain significance Single submitter
- SNRPA1 p.Gln43Glu Uncertain significance Single submitter
- SNRPA1 p.Glu233Gly Uncertain significance Single submitter
- SNRPA1 p.Glu244Asp Uncertain significance Single submitter
- SNRPA1 p.Gly167Ala Uncertain significance Single submitter
- SNRPA1 p.Gly195Ala Uncertain significance Single submitter
- SNRPA1 p.Leu112Phe Uncertain significance Single submitter
- SNRPA1 p.Leu90Val Uncertain significance Single submitter
- SNRPA1 p.Pro108Arg Uncertain significance Single submitter
- SNRPA1 p.Pro188Ser Uncertain significance Single submitter
- SNRPA1 p.Tyr29Cys Uncertain significance Single submitter
- SNRPA1 p.Val101Met Uncertain significance Single submitter
- SNRPA1 p.Val33Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SNRPA1 p.Arg234Cys Uncertain significance Single submitter
- SNRPA1 p.Glu218Gln Uncertain significance Single submitter
- SNRPA1 p.Glu248Lys Uncertain significance Single submitter
- SNRPA1 p.Glu53Asp Uncertain significance Single submitter
- SNRPA1 p.Leu133Ser Uncertain significance Single submitter
- SNRPA1 p.Lys67Asn Uncertain significance Single submitter
- SNRPA1 p.Ser114Leu Uncertain significance Single submitter
All SNRPA1 variants
Uncertain significance 25
- p.Arg234Cys Single submitter ⚠
- p.Arg234His Single submitter ⚠
- p.Arg78Cys Single submitter ⚠
- p.Asp190Gly Single submitter ⚠
- p.Asp200Glu Single submitter ⚠
- p.Asp249Gly Single submitter ⚠
- p.Asp58Val Single submitter ⚠
- p.Gln43Glu Single submitter ⚠
- p.Glu218Gln Single submitter ⚠
- p.Glu233Gly Single submitter ⚠
- p.Glu244Asp Single submitter ⚠
- p.Glu248Lys Single submitter ⚠
- p.Glu53Asp Single submitter ⚠
- p.Gly167Ala Single submitter ⚠
- p.Gly195Ala Single submitter ⚠
- p.Leu112Phe Single submitter ⚠
- p.Leu133Ser Single submitter ⚠
- p.Leu90Val Single submitter ⚠
- p.Lys67Asn Single submitter ⚠
- p.Pro108Arg Single submitter ⚠
- p.Pro188Ser Single submitter ⚠
- p.Ser114Leu Single submitter ⚠
- p.Tyr29Cys Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val33Ile Single submitter ⚠