SNRPB2 — 20 ClinVar variants
All ClinVar germline SNRPB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
1 Likely benign · 19 Uncertain significance
Full SNRPB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SNRPB2 p.Ala99Gly Uncertain significance Single submitter
- SNRPB2 p.Arg49Met Uncertain significance Single submitter
- SNRPB2 p.Asn121Asp Uncertain significance Single submitter
- SNRPB2 p.Asp89Val Uncertain significance Single submitter
- SNRPB2 p.Phe31Cys Uncertain significance Single submitter
- SNRPB2 p.Thr119Ile Uncertain significance Single submitter
- SNRPB2 p.Thr139Ile Uncertain significance Single submitter
- SNRPB2 p.Tyr10Cys Uncertain significance Single submitter
- SNRPB2 p.Tyr151Cys Uncertain significance Single submitter
- SNRPB2 p.Val113Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SNRPB2 p.Ala29Gly Uncertain significance Single submitter
- SNRPB2 p.Arg49Lys Uncertain significance Single submitter
- SNRPB2 p.Gly60Asp Uncertain significance Single submitter
- SNRPB2 p.Gly76Asp Uncertain significance Single submitter
- SNRPB2 p.Ile189Val Uncertain significance Single submitter
- SNRPB2 p.Ile212Val Uncertain significance Single submitter
- SNRPB2 p.Lys17Arg Uncertain significance Single submitter
- SNRPB2 p.Phe177Leu Uncertain significance Single submitter
All SNRPB2 variants
Likely benign 1
- p.Gln173= Single submitter
Uncertain significance 19
- p.Ala29Gly Single submitter ⚠
- p.Ala99Gly Single submitter ⚠
- p.Arg49Lys Single submitter ⚠
- p.Arg49Met Single submitter ⚠
- p.Asn121Asp Single submitter ⚠
- p.Asp89Val Single submitter ⚠
- p.Gly60Asp Single submitter ⚠
- p.Gly76Asp Single submitter ⚠
- p.His36Arg Single submitter
- p.Ile189Val Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Lys17Arg Single submitter ⚠
- p.Phe177Leu Single submitter ⚠
- p.Phe31Cys Single submitter ⚠
- p.Thr119Ile Single submitter ⚠
- p.Thr139Ile Single submitter ⚠
- p.Tyr10Cys Single submitter ⚠
- p.Tyr151Cys Single submitter ⚠
- p.Val113Met Single submitter ⚠