SNX1 — 69 ClinVar variants
All ClinVar germline SNX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
69 Uncertain significance
Full SNX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SNX1 p.Ala36Gly Uncertain significance Single submitter
- SNX1 p.Ala90Thr Uncertain significance Single submitter
- SNX1 p.Arg365Gln Uncertain significance Single submitter
- SNX1 p.Arg407His Uncertain significance Single submitter
- SNX1 p.Arg419Cys Uncertain significance Single submitter
- SNX1 p.Arg419His Uncertain significance Single submitter
- SNX1 p.Arg431Trp Uncertain significance Single submitter
- SNX1 p.Arg459Trp Uncertain significance Single submitter
- SNX1 p.Asn204Ser Uncertain significance Single submitter
- SNX1 p.Asn387Thr Uncertain significance Single submitter
- SNX1 p.Asn69Ser Uncertain significance Single submitter
- SNX1 p.Gln462Arg Uncertain significance Single submitter
- SNX1 p.Gln505His Uncertain significance Single submitter
- SNX1 p.Glu140Gly Uncertain significance Single submitter
- SNX1 p.Glu213Asp Uncertain significance Single submitter
- SNX1 p.Glu263Asp Uncertain significance Single submitter
- SNX1 p.Glu372Asp Uncertain significance Single submitter
- SNX1 p.Glu457Ala Uncertain significance Single submitter
- SNX1 p.Gly158Ser Uncertain significance Single submitter
- SNX1 p.Gly27Arg Uncertain significance Single submitter
- SNX1 p.Gly30Arg Uncertain significance Single submitter
- SNX1 p.Gly31Glu Uncertain significance Single submitter
- SNX1 p.Gly71Val Uncertain significance Single submitter
- SNX1 p.His492Arg Uncertain significance Single submitter
- SNX1 p.His78Arg Uncertain significance Single submitter
- SNX1 p.Ile68Thr Uncertain significance Single submitter
- SNX1 p.Leu113Val Uncertain significance Single submitter
- SNX1 p.Leu285Phe Uncertain significance Single submitter
- SNX1 p.Leu313Val Uncertain significance Single submitter
- SNX1 p.Leu65Phe Uncertain significance Single submitter
- SNX1 p.Lys73Glu Uncertain significance Single submitter
- SNX1 p.Lys73Ile Uncertain significance Single submitter
- SNX1 p.Phe206Tyr Uncertain significance Single submitter
- SNX1 p.Phe47Ser Uncertain significance Single submitter
- SNX1 p.Pro118Leu Uncertain significance Single submitter
- SNX1 p.Pro259Ala Uncertain significance Single submitter
- SNX1 p.Pro271Thr Uncertain significance Single submitter
- SNX1 p.Pro85Ser Uncertain significance Single submitter
- SNX1 p.Ser125Leu Uncertain significance Single submitter
- SNX1 p.Ser229Pro Uncertain significance Single submitter
- SNX1 p.Ser231Tyr Uncertain significance Single submitter
- SNX1 p.Ser305Ala Uncertain significance Single submitter
- SNX1 p.Ser368Phe Uncertain significance Single submitter
- SNX1 p.Thr130Ala Uncertain significance Single submitter
- SNX1 p.Thr48Ala Uncertain significance Single submitter
- SNX1 p.Thr499Ser Uncertain significance Single submitter
- SNX1 p.Thr93Ala Uncertain significance Single submitter
- SNX1 p.Tyr194His Uncertain significance Single submitter
- SNX1 p.Val147Gly Uncertain significance Single submitter
- SNX1 p.Val329Leu Uncertain significance Single submitter
- SNX1 p.Val493Met Uncertain significance Single submitter
- SNX1 p.Val94Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SNX1 p.Ala513Asp Uncertain significance Single submitter
- SNX1 p.Arg480Gln Uncertain significance Single submitter
- SNX1 p.Asp488Asn Uncertain significance Single submitter
- SNX1 p.Glu153Lys Uncertain significance Single submitter
- SNX1 p.Leu342Arg Uncertain significance Single submitter
- SNX1 p.Ser172Arg Uncertain significance Single submitter
- SNX1 p.Ser305Pro Uncertain significance Single submitter
- SNX1 p.Val261Phe Uncertain significance Single submitter
All SNX1 variants
Uncertain significance 69
- c.732-2A>G Single submitter
- p.Ala241Thr Single submitter
- p.Ala36Gly Single submitter ⚠
- p.Ala513Asp Single submitter ⚠
- p.Ala90Thr Single submitter ⚠
- p.Arg365Gln Single submitter ⚠
- p.Arg407His Single submitter ⚠
- p.Arg419Cys Single submitter ⚠
- p.Arg419His Single submitter ⚠
- p.Arg431Gln Single submitter
- p.Arg431Trp Single submitter ⚠
- p.Arg459Trp Single submitter ⚠
- p.Arg480Gln Single submitter ⚠
- p.Arg480Trp Single submitter
- p.Asn204Ser Single submitter ⚠
- p.Asn387Thr Single submitter ⚠
- p.Asn69Ser Single submitter ⚠
- p.Asp488Asn Single submitter ⚠
- p.Gln102Ter Single submitter
- p.Gln462Arg Single submitter ⚠
- p.Gln505His Single submitter ⚠
- p.Glu140Gly Single submitter ⚠
- p.Glu153Lys Single submitter ⚠
- p.Glu213Asp Single submitter ⚠
- p.Glu263Asp Single submitter ⚠
- p.Glu372Asp Single submitter ⚠
- p.Glu457Ala Single submitter ⚠
- p.Gly158Ser Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly31Glu Single submitter ⚠
- p.Gly71Val Single submitter ⚠
- p.His252fs Single submitter
- p.His492Arg Single submitter ⚠
- p.His78Arg Single submitter ⚠
- p.Ile68Thr Single submitter ⚠
- p.Leu113Val Single submitter ⚠
- p.Leu285Phe Single submitter ⚠
- p.Leu313Val Single submitter ⚠
- p.Leu342Arg Single submitter ⚠
- p.Leu367Val Single submitter
- p.Leu65Phe Single submitter ⚠
- p.Lys73Glu Single submitter ⚠
- p.Lys73Ile Single submitter ⚠
- p.Phe143Cys Single submitter
- p.Phe206Tyr Single submitter ⚠
- p.Phe47Ser Single submitter ⚠
- p.Pro118Leu Single submitter ⚠
- p.Pro259Ala Single submitter ⚠
- p.Pro271Thr Single submitter ⚠
- p.Pro85Ser Single submitter ⚠
- p.Ser125Leu Single submitter ⚠
- p.Ser172Arg Single submitter ⚠
- p.Ser229Pro Single submitter ⚠
- p.Ser231Tyr Single submitter ⚠
- p.Ser305Ala Single submitter ⚠
- p.Ser305Pro Single submitter ⚠
- p.Ser368Phe Single submitter ⚠
- p.Thr130Ala Single submitter ⚠
- p.Thr361Met Single submitter
- p.Thr48Ala Single submitter ⚠
- p.Thr499Ser Single submitter ⚠
- p.Thr93Ala Single submitter ⚠
- p.Tyr194His Single submitter ⚠
- p.Val147Gly Single submitter ⚠
- p.Val261Phe Single submitter ⚠
- p.Val329Leu Single submitter ⚠
- p.Val493Met Single submitter ⚠
- p.Val94Met Single submitter ⚠