SNX2 — 59 ClinVar variants
All ClinVar germline SNX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
59 Uncertain significance
Full SNX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SNX2 p.Ala135Pro Uncertain significance Single submitter
- SNX2 p.Ala519Asp Uncertain significance Single submitter
- SNX2 p.Arg5Lys Uncertain significance Single submitter
- SNX2 p.Asn55Ile Uncertain significance Single submitter
- SNX2 p.Asp12Tyr Uncertain significance Single submitter
- SNX2 p.Asp141Val Uncertain significance Single submitter
- SNX2 p.Asp290Asn Uncertain significance Single submitter
- SNX2 p.Asp290Glu Uncertain significance Single submitter
- SNX2 p.Asp290Gly Uncertain significance Single submitter
- SNX2 p.Asp485Asn Uncertain significance Single submitter
- SNX2 p.Asp72Tyr Uncertain significance Single submitter
- SNX2 p.Gln244Arg Uncertain significance Single submitter
- SNX2 p.Gln379Arg Uncertain significance Single submitter
- SNX2 p.Gln379Lys Uncertain significance Single submitter
- SNX2 p.Gln415Lys Uncertain significance Single submitter
- SNX2 p.Glu134Ala Uncertain significance Single submitter
- SNX2 p.Glu4Asp Uncertain significance Single submitter
- SNX2 p.Glu6Asp Uncertain significance Single submitter
- SNX2 p.Glu89Lys Uncertain significance Single submitter
- SNX2 p.Gly11Val Uncertain significance Single submitter
- SNX2 p.Gly13Arg Uncertain significance Single submitter
- SNX2 p.Gly405Ser Uncertain significance Single submitter
- SNX2 p.Ile123Ser Uncertain significance Single submitter
- SNX2 p.Ile467Val Uncertain significance Single submitter
- SNX2 p.Ile518Val Uncertain significance Single submitter
- SNX2 p.Leu393Phe Uncertain significance Single submitter
- SNX2 p.Leu504Met Uncertain significance Single submitter
- SNX2 p.Lys335Arg Uncertain significance Single submitter
- SNX2 p.Lys404Arg Uncertain significance Single submitter
- SNX2 p.Lys433Arg Uncertain significance Single submitter
- SNX2 p.Phe124Cys Uncertain significance Single submitter
- SNX2 p.Pro102Leu Uncertain significance Single submitter
- SNX2 p.Pro149Leu Uncertain significance Single submitter
- SNX2 p.Pro513Leu Uncertain significance Single submitter
- SNX2 p.Pro59Leu Uncertain significance Single submitter
- SNX2 p.Pro90Leu Uncertain significance Single submitter
- SNX2 p.Pro9Ala Uncertain significance Single submitter
- SNX2 p.Ser179Thr Uncertain significance Single submitter
- SNX2 p.Thr470Met Uncertain significance Single submitter
- SNX2 p.Tyr387Cys Uncertain significance Single submitter
- SNX2 p.Val122Met Uncertain significance Single submitter
- SNX2 p.Val457Ala Uncertain significance Single submitter
- SNX2 p.Val489Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SNX2 p.Ala2Val Uncertain significance Single submitter
- SNX2 p.Asp356Glu Uncertain significance Single submitter
- SNX2 p.Glu134Lys Uncertain significance Single submitter
- SNX2 p.Glu22Lys Uncertain significance Single submitter
- SNX2 p.Glu6Lys Uncertain significance Single submitter
- SNX2 p.His378Tyr Uncertain significance Single submitter
- SNX2 p.Leu276Val Uncertain significance Single submitter
- SNX2 p.Val370Ala Uncertain significance Single submitter
All SNX2 variants
Uncertain significance 59
- c.226+2T>C Single submitter
- c.227-1G>A Single submitter
- c.644-2A>G Single submitter
- p.Ala135Pro Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala519Asp Single submitter ⚠
- p.Arg398His Single submitter
- p.Arg472Ter Single submitter
- p.Arg5Lys Single submitter ⚠
- p.Asn55Ile Single submitter ⚠
- p.Asp12Tyr Single submitter ⚠
- p.Asp141Val Single submitter ⚠
- p.Asp290Asn Single submitter ⚠
- p.Asp290Glu Single submitter ⚠
- p.Asp290Gly Single submitter ⚠
- p.Asp356Glu Single submitter ⚠
- p.Asp485Asn Single submitter ⚠
- p.Asp69His Single submitter
- p.Asp72Tyr Single submitter ⚠
- p.Gln244Arg Single submitter ⚠
- p.Gln379Arg Single submitter ⚠
- p.Gln379Lys Single submitter ⚠
- p.Gln415Lys Single submitter ⚠
- p.Glu134Ala Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Glu4Asp Single submitter ⚠
- p.Glu6Asp Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly11Val Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly405Ser Single submitter ⚠
- p.His378Tyr Single submitter ⚠
- p.Ile123Ser Single submitter ⚠
- p.Ile467Val Single submitter ⚠
- p.Ile518Val Single submitter ⚠
- p.Leu276Val Single submitter ⚠
- p.Leu393Phe Single submitter ⚠
- p.Leu504Met Single submitter ⚠
- p.Lys335Arg Single submitter ⚠
- p.Lys404Arg Single submitter ⚠
- p.Lys433Arg Single submitter ⚠
- p.Phe124Cys Single submitter ⚠
- p.Pro102Leu Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro513Leu Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Pro7Arg Single submitter
- p.Pro90Leu Single submitter ⚠
- p.Pro9Ala Single submitter ⚠
- p.Ser179Thr Single submitter ⚠
- p.Thr470Met Single submitter ⚠
- p.Tyr387Cys Single submitter ⚠
- p.Val122Met Single submitter ⚠
- p.Val370Ala Single submitter ⚠
- p.Val403Leu Single submitter
- p.Val457Ala Single submitter ⚠
- p.Val489Ile Single submitter ⚠