Sugi Variant

Sugi Variant/SNX27

SNX27 — 417 ClinVar variants

All ClinVar germline SNX27 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 145 flagged for review →

17 Pathogenic · 1 Pathogenic/Likely pathogenic · 4 Likely pathogenic · 2 Conflicting · 13 Benign · 2 Benign/Likely benign · 212 Likely benign · 166 Uncertain significance

Full SNX27 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 145

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 88

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 56

The independent predictors disagree with each other — read with care.

All SNX27 variants

Pathogenic 17

Pathogenic/Likely pathogenic 1

Likely pathogenic 4

Conflicting classifications of pathogenicity 2

Benign 13

Benign/Likely benign 2

Likely benign 212

Uncertain significance 166