SNX9 — 52 ClinVar variants
All ClinVar germline SNX9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Benign · 1 Benign/Likely benign · 3 Likely benign · 47 Uncertain significance
Full SNX9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SNX9 p.Ala212Val Uncertain significance Single submitter
- SNX9 p.Ala255Thr Uncertain significance Single submitter
- SNX9 p.Ala2Thr Uncertain significance Single submitter
- SNX9 p.Ala333Thr Uncertain significance Single submitter
- SNX9 p.Ala513Gly Uncertain significance Single submitter
- SNX9 p.Arg43Thr Uncertain significance Single submitter
- SNX9 p.Arg559Gln Uncertain significance Single submitter
- SNX9 p.Asn355Ile Uncertain significance Single submitter
- SNX9 p.Asp372Asn Uncertain significance Single submitter
- SNX9 p.Gln155Pro Uncertain significance Single submitter
- SNX9 p.Glu321Asp Uncertain significance Single submitter
- SNX9 p.Glu572Lys Uncertain significance Single submitter
- SNX9 p.Gly102Asp Uncertain significance Single submitter
- SNX9 p.Gly187Ala Uncertain significance Single submitter
- SNX9 p.Ile305Val Uncertain significance Single submitter
- SNX9 p.Ile507Val Uncertain significance Single submitter
- SNX9 p.Ile560Thr Uncertain significance Single submitter
- SNX9 p.Leu354Val Uncertain significance Single submitter
- SNX9 p.Lys229Ile Uncertain significance Single submitter
- SNX9 p.Phe449Cys Uncertain significance Single submitter
- SNX9 p.Pro141Arg Uncertain significance Single submitter
- SNX9 p.Pro306Arg Uncertain significance Single submitter
- SNX9 p.Pro311Ser Uncertain significance Single submitter
- SNX9 p.Ser175Thr Uncertain significance Single submitter
- SNX9 p.Ser194Ile Uncertain significance Single submitter
- SNX9 p.Ser303Pro Uncertain significance Single submitter
- SNX9 p.Ser86Arg Uncertain significance Single submitter
- SNX9 p.Thr21Ser Uncertain significance Single submitter
- SNX9 p.Thr249Pro Uncertain significance Single submitter
- SNX9 p.Thr277Ser Uncertain significance Single submitter
- SNX9 p.Thr428Ser Uncertain significance Single submitter
- SNX9 p.Thr87Ala Uncertain significance Single submitter
- SNX9 p.Tyr454Ser Uncertain significance Single submitter
- SNX9 p.Val538Met Uncertain significance Single submitter
- SNX9 p.Val74Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SNX9 p.Arg195Cys Uncertain significance Single submitter
- SNX9 p.Asn32Asp Uncertain significance Single submitter
- SNX9 p.Ile28Phe Uncertain significance Single submitter
- SNX9 p.Leu293Phe Uncertain significance Single submitter
- SNX9 p.Met595Thr Uncertain significance Single submitter
- SNX9 p.Pro233Leu Uncertain significance Single submitter
- SNX9 p.Pro432Thr Uncertain significance Single submitter
- SNX9 p.Val419Met Uncertain significance Single submitter
All SNX9 variants
Benign 1
- c.1443+8C>T Single submitter
Benign/Likely benign 1
- p.Asp180Asn Multiple submitters
Likely benign 3
- c.950-9C>T Multiple submitters
- p.Asp162= Single submitter
- p.Glu130Asp Single submitter
Uncertain significance 47
- p.Ala212Val Single submitter ⚠
- p.Ala255Thr Single submitter ⚠
- p.Ala2Thr Single submitter ⚠
- p.Ala333Thr Single submitter ⚠
- p.Ala401Asp Single submitter
- p.Ala513Gly Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg43Thr Single submitter ⚠
- p.Arg559Gln Single submitter ⚠
- p.Asn32Asp Single submitter ⚠
- p.Asn355Ile Single submitter ⚠
- p.Asp170Tyr Single submitter
- p.Asp372Asn Single submitter ⚠
- p.Gln155Pro Single submitter ⚠
- p.Glu321Asp Single submitter ⚠
- p.Glu396Gly Single submitter
- p.Glu572Lys Single submitter ⚠
- p.Gly102Asp Single submitter ⚠
- p.Gly187Ala Single submitter ⚠
- p.Ile28Phe Single submitter ⚠
- p.Ile305Val Single submitter ⚠
- p.Ile507Val Single submitter ⚠
- p.Ile560Thr Single submitter ⚠
- p.Leu293Phe Single submitter ⚠
- p.Leu354Val Single submitter ⚠
- p.Leu390Ser Single submitter
- p.Lys229Ile Single submitter ⚠
- p.Met595Thr Single submitter ⚠
- p.Phe449Cys Single submitter ⚠
- p.Pro141Arg Single submitter ⚠
- p.Pro233Leu Single submitter ⚠
- p.Pro306Arg Single submitter ⚠
- p.Pro311Ser Single submitter ⚠
- p.Pro432Thr Single submitter ⚠
- p.Ser175Thr Single submitter ⚠
- p.Ser194Ile Single submitter ⚠
- p.Ser303Pro Single submitter ⚠
- p.Ser86Arg Single submitter ⚠
- p.Thr21Ser Single submitter ⚠
- p.Thr249Pro Single submitter ⚠
- p.Thr277Ser Single submitter ⚠
- p.Thr428Ser Single submitter ⚠
- p.Thr87Ala Single submitter ⚠
- p.Tyr454Ser Single submitter ⚠
- p.Val419Met Single submitter ⚠
- p.Val538Met Single submitter ⚠
- p.Val74Leu Single submitter ⚠