SOD3 — 67 ClinVar variants
All ClinVar germline SOD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
6 Benign · 5 Likely benign · 56 Uncertain significance
Full SOD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SOD3 p.Ala150Val Uncertain significance Single submitter
- SOD3 p.Ala161Val Uncertain significance Single submitter
- SOD3 p.Ala168Thr Uncertain significance Single submitter
- SOD3 p.Ala222Thr Uncertain significance Single submitter
- SOD3 p.Ala25Ser Uncertain significance Single submitter
- SOD3 p.Ala25Val Uncertain significance Single submitter
- SOD3 p.Ala32Thr Uncertain significance Single submitter
- SOD3 p.Ala88Gly Uncertain significance Single submitter
- SOD3 p.Ala88Thr Uncertain significance Single submitter
- SOD3 p.Ala98Ser Uncertain significance Single submitter
- SOD3 p.Arg189Leu Uncertain significance Single submitter
- SOD3 p.Arg220Leu Uncertain significance Single submitter
- SOD3 p.Arg223Leu Uncertain significance Single submitter
- SOD3 p.Arg228Leu Uncertain significance Single submitter
- SOD3 p.Arg228Ser Uncertain significance Single submitter
- SOD3 p.Arg53Pro Uncertain significance Single submitter
- SOD3 p.Arg77Gly Uncertain significance Single submitter
- SOD3 p.Asn192His Uncertain significance Single submitter
- SOD3 p.Asn200Lys Uncertain significance Single submitter
- SOD3 p.Asp17Glu Uncertain significance Single submitter
- SOD3 p.Asp185Asn Uncertain significance Single submitter
- SOD3 p.Asp186Val Uncertain significance Single submitter
- SOD3 p.Asp23Gly Uncertain significance Single submitter
- SOD3 p.Asp56Asn Uncertain significance Single submitter
- SOD3 p.Asp72Gly Uncertain significance Single submitter
- SOD3 p.Cys125Trp Uncertain significance Single submitter
- SOD3 p.Gln123Glu Uncertain significance Single submitter
- SOD3 p.Gln193Lys Uncertain significance Single submitter
- SOD3 p.Gln221Glu Uncertain significance Single submitter
- SOD3 p.Gln221Leu Uncertain significance Single submitter
- SOD3 p.Glu184Lys Uncertain significance Single submitter
- SOD3 p.Glu197Lys Uncertain significance Single submitter
- SOD3 p.Glu236Gln Uncertain significance Single submitter
- SOD3 p.Glu48Asp Uncertain significance Single submitter
- SOD3 p.Glu48Val Uncertain significance Single submitter
- SOD3 p.Gly101Ser Uncertain significance Single submitter
- SOD3 p.Gly119Ala Uncertain significance Single submitter
- SOD3 p.Gly199Arg Uncertain significance Single submitter
- SOD3 p.Gly57Arg Uncertain significance Single submitter
- SOD3 p.Gly80Ala Uncertain significance Single submitter
- SOD3 p.Ile35Val Uncertain significance Single submitter
- SOD3 p.Pro134Leu Uncertain significance Single submitter
- SOD3 p.Pro170Gln Uncertain significance Single submitter
- SOD3 p.Pro67Arg Uncertain significance Single submitter
- SOD3 p.Pro89Thr Uncertain significance Single submitter
- SOD3 p.Ser122Arg Uncertain significance Single submitter
- SOD3 p.Ser31Pro Uncertain significance Single submitter
- SOD3 p.Thr20Met Uncertain significance Single submitter
- SOD3 p.Tyr159Cys Uncertain significance Single submitter
- SOD3 p.Val179Gly Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All SOD3 variants
Benign 6
- p.Ala3= Multiple submitters
- p.Ala91Thr Single submitter
- p.Arg231Gly Single submitter SOD3-related disorder ⚠
- p.Ser31= Single submitter
- p.Ala58Thr No assertion criteria SOD3-related disorder
- p.Leu71= No assertion criteria SOD3-related disorder
Likely benign 5
- p.Ala201= Single submitter
- p.Glu105Gln Single submitter
- p.Tyr39= Single submitter
- p.Asn28Ser No assertion criteria SOD3-related disorder
- p.Gly175Asp No assertion criteria SOD3-related disorder
Uncertain significance 56
- p.Ala150Val Single submitter ⚠
- p.Ala161Val Single submitter ⚠
- p.Ala168Thr Single submitter ⚠
- p.Ala177Thr Single submitter
- p.Ala222Thr Single submitter ⚠
- p.Ala25Ser Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Ala88Gly Single submitter ⚠
- p.Ala88Thr Single submitter ⚠
- p.Ala98Ser Single submitter ⚠
- p.Arg189Leu Single submitter ⚠
- p.Arg220Leu Single submitter ⚠
- p.Arg223Leu Single submitter ⚠
- p.Arg228Leu Single submitter ⚠
- p.Arg228Ser Single submitter ⚠
- p.Arg53Pro Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Asn192His Single submitter ⚠
- p.Asn200Lys Single submitter ⚠
- p.Asp17Glu Single submitter ⚠
- p.Asp185Asn Single submitter ⚠
- p.Asp186Val Single submitter ⚠
- p.Asp23Gly Single submitter ⚠
- p.Asp56Asn Single submitter ⚠
- p.Asp72Gly Single submitter ⚠
- p.Cys125Trp Single submitter ⚠
- p.Gln123Glu Single submitter ⚠
- p.Gln193Lys Single submitter ⚠
- p.Gln221Glu Single submitter ⚠
- p.Gln221Leu Single submitter ⚠
- p.Gln47Ter Single submitter
- p.Glu184Lys Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Glu236Gln Single submitter ⚠
- p.Glu48Asp Single submitter ⚠
- p.Glu48Val Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly119Ala Single submitter ⚠
- p.Gly191Ser Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly57Arg Single submitter ⚠
- p.Gly80Ala Single submitter ⚠
- p.Ile35Val Single submitter ⚠
- p.Leu11Gln Single submitter ⚠
- p.Leu4Pro Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro170Gln Single submitter ⚠
- p.Pro67Arg Single submitter ⚠
- p.Pro89Thr Single submitter ⚠
- p.Ser122Arg Single submitter ⚠
- p.Ser31Pro Single submitter ⚠
- p.Ser68Pro Single submitter ⚠
- p.Thr20Met Single submitter ⚠
- p.Tyr159Cys Single submitter ⚠
- p.Val179Gly Single submitter ⚠