SPIN2A — 40 ClinVar variants
All ClinVar germline SPIN2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
3 Likely benign · 37 Uncertain significance
Full SPIN2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SPIN2A p.Arg113Thr Uncertain significance Single submitter
- SPIN2A p.Arg38Lys Uncertain significance Single submitter
- SPIN2A p.Arg47Ser Uncertain significance Single submitter
- SPIN2A p.Asp180Gly Uncertain significance Single submitter
- SPIN2A p.Asp253His Uncertain significance Single submitter
- SPIN2A p.Glu199Asp Uncertain significance Single submitter
- SPIN2A p.Glu201Lys Uncertain significance Single submitter
- SPIN2A p.Glu233Lys Uncertain significance Single submitter
- SPIN2A p.Glu97Gln Uncertain significance Single submitter
- SPIN2A p.Gly130Asp Uncertain significance Single submitter
- SPIN2A p.Gly184Asp Uncertain significance Single submitter
- SPIN2A p.Gly221Ser Uncertain significance Single submitter
- SPIN2A p.His230Tyr Uncertain significance Single submitter
- SPIN2A p.Ile210Thr Uncertain significance Single submitter
- SPIN2A p.Ile78Thr Uncertain significance Single submitter
- SPIN2A p.Leu178Ile Uncertain significance Single submitter
- SPIN2A p.Leu84Pro Uncertain significance Single submitter
- SPIN2A p.Lys242Glu Uncertain significance Single submitter
- SPIN2A p.Lys257Thr Uncertain significance Single submitter
- SPIN2A p.Lys69Gln Uncertain significance Single submitter
- SPIN2A p.Met136Thr Uncertain significance Single submitter
- SPIN2A p.Met189Val Uncertain significance Single submitter
- SPIN2A p.Pro202Arg Uncertain significance Single submitter
- SPIN2A p.Thr71Pro Uncertain significance Single submitter
- SPIN2A p.Trp68Cys Uncertain significance Single submitter
- SPIN2A p.Tyr83Ser Uncertain significance Single submitter
- SPIN2A p.Val114Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SPIN2A p.Ala155Pro Uncertain significance Single submitter
- SPIN2A p.Arg187Cys Uncertain significance Single submitter
- SPIN2A p.Gly130Ser Uncertain significance Single submitter
- SPIN2A p.Lys69Asn Uncertain significance Single submitter
- SPIN2A p.Met174Thr Uncertain significance Single submitter
- SPIN2A p.Pro170His Uncertain significance Single submitter
- SPIN2A p.Val228Ala Uncertain significance Single submitter
All SPIN2A variants
Likely benign 3
- p.Arg40Gln Single submitter
- p.Gly70= Single submitter
- p.Thr234Ala Single submitter
Uncertain significance 37
- p.Ala155Pro Single submitter ⚠
- p.Arg113Thr Single submitter ⚠
- p.Arg187Cys Single submitter ⚠
- p.Arg38Lys Single submitter ⚠
- p.Arg47Ser Single submitter ⚠
- p.Asp180Gly Single submitter ⚠
- p.Asp253His Single submitter ⚠
- p.Glu138Gln Single submitter
- p.Glu199Asp Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu97Gln Single submitter ⚠
- p.Gly130Asp Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly184Asp Single submitter ⚠
- p.Gly221Ser Single submitter ⚠
- p.His230Tyr Single submitter ⚠
- p.Ile210Thr Single submitter ⚠
- p.Ile78Thr Single submitter ⚠
- p.Leu178Ile Single submitter ⚠
- p.Leu84Pro Single submitter ⚠
- p.Lys242Glu Single submitter ⚠
- p.Lys257Thr Single submitter ⚠
- p.Lys69Asn Single submitter ⚠
- p.Lys69Gln Single submitter ⚠
- p.Lys69Thr Single submitter
- p.Met136Thr Single submitter ⚠
- p.Met174Thr Single submitter ⚠
- p.Met189Val Single submitter ⚠
- p.Pro170His Single submitter ⚠
- p.Pro202Arg Single submitter ⚠
- p.Ser237Phe Single submitter
- p.Thr71Pro Single submitter ⚠
- p.Trp68Cys Single submitter ⚠
- p.Tyr83Ser Single submitter ⚠
- p.Val114Met Single submitter ⚠
- p.Val228Ala Single submitter ⚠