SPIN3 — 26 ClinVar variants
All ClinVar germline SPIN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Likely benign · 25 Uncertain significance
Full SPIN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SPIN3 p.Ala33Thr Uncertain significance Single submitter
- SPIN3 p.Arg187His Uncertain significance Single submitter
- SPIN3 p.Arg46Trp Uncertain significance Single submitter
- SPIN3 p.Asn112Ile Uncertain significance Single submitter
- SPIN3 p.Asp169Glu Uncertain significance Single submitter
- SPIN3 p.Asp191Asn Uncertain significance Single submitter
- SPIN3 p.Gly11Glu Uncertain significance Single submitter
- SPIN3 p.Gly142Val Uncertain significance Single submitter
- SPIN3 p.His99Asp Uncertain significance Single submitter
- SPIN3 p.Leu124Phe Uncertain significance Single submitter
- SPIN3 p.Leu65Pro Uncertain significance Single submitter
- SPIN3 p.Lys242Arg Uncertain significance Single submitter
- SPIN3 p.Lys69Glu Uncertain significance Single submitter
- SPIN3 p.Met27Arg Uncertain significance Single submitter
- SPIN3 p.Ser120Arg Uncertain significance Single submitter
- SPIN3 p.Ser208Asn Uncertain significance Single submitter
- SPIN3 p.Thr42Ile Uncertain significance Single submitter
- SPIN3 p.Thr42Ser Uncertain significance Single submitter
- SPIN3 p.Val72Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- SPIN3 p.Arg103Gly Uncertain significance Single submitter
- SPIN3 p.His248Arg Uncertain significance Single submitter
- SPIN3 p.Ile249Met Uncertain significance Single submitter
- SPIN3 p.Thr165Asn Uncertain significance Single submitter
- SPIN3 p.Thr66Ile Uncertain significance Single submitter
- SPIN3 p.Val232Leu Uncertain significance Single submitter
All SPIN3 variants
Likely benign 1
- p.Arg46Gln Single submitter
Uncertain significance 25
- p.Ala33Thr Single submitter ⚠
- p.Arg103Gly Single submitter ⚠
- p.Arg187His Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Asn112Ile Single submitter ⚠
- p.Asp169Glu Single submitter ⚠
- p.Asp191Asn Single submitter ⚠
- p.Gly11Glu Single submitter ⚠
- p.Gly142Val Single submitter ⚠
- p.His248Arg Single submitter ⚠
- p.His99Asp Single submitter ⚠
- p.Ile249Met Single submitter ⚠
- p.Leu124Phe Single submitter ⚠
- p.Leu65Pro Single submitter ⚠
- p.Lys242Arg Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Met27Arg Single submitter ⚠
- p.Ser120Arg Single submitter ⚠
- p.Ser208Asn Single submitter ⚠
- p.Thr165Asn Single submitter ⚠
- p.Thr42Ile Single submitter ⚠
- p.Thr42Ser Single submitter ⚠
- p.Thr66Ile Single submitter ⚠
- p.Val232Leu Single submitter ⚠
- p.Val72Ile Single submitter ⚠