SPSB3 — 87 ClinVar variants
All ClinVar germline SPSB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
1 Benign · 7 Likely benign · 79 Uncertain significance
Full SPSB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SPSB3 p.Ala18Val Uncertain significance Single submitter
- SPSB3 p.Ala22Thr Uncertain significance Single submitter
- SPSB3 p.Ala274Ser Uncertain significance Single submitter
- SPSB3 p.Ala334Val Uncertain significance Single submitter
- SPSB3 p.Ala337Thr Uncertain significance Single submitter
- SPSB3 p.Arg20Gly Uncertain significance Single submitter
- SPSB3 p.Arg269His Uncertain significance Single submitter
- SPSB3 p.Arg323His Uncertain significance Single submitter
- SPSB3 p.Arg324Gly Uncertain significance Single submitter
- SPSB3 p.Arg342Gly Uncertain significance Single submitter
- SPSB3 p.Arg353Gly Uncertain significance Single submitter
- SPSB3 p.Arg353His Uncertain significance Single submitter
- SPSB3 p.Arg354Gln Uncertain significance Single submitter
- SPSB3 p.Arg90Trp Uncertain significance Single submitter
- SPSB3 p.Arg95His Uncertain significance Single submitter
- SPSB3 p.Asp109Asn Uncertain significance Single submitter
- SPSB3 p.Asp163Asn Uncertain significance Single submitter
- SPSB3 p.Asp174Asn Uncertain significance Single submitter
- SPSB3 p.Asp206His Uncertain significance Single submitter
- SPSB3 p.Asp291Asn Uncertain significance Single submitter
- SPSB3 p.Asp330Asn Uncertain significance Single submitter
- SPSB3 p.Asp330His Uncertain significance Single submitter
- SPSB3 p.Asp45Asn Uncertain significance Single submitter
- SPSB3 p.Asp93Gly Uncertain significance Single submitter
- SPSB3 p.Cys120Phe Uncertain significance Single submitter
- SPSB3 p.Cys120Tyr Uncertain significance Single submitter
- SPSB3 p.Cys271Trp Uncertain significance Single submitter
- SPSB3 p.Cys352Arg Uncertain significance Single submitter
- SPSB3 p.Cys73Ser Uncertain significance Single submitter
- SPSB3 p.Cys82Tyr Uncertain significance Single submitter
- SPSB3 p.Gln248Arg Uncertain significance Single submitter
- SPSB3 p.Gln348His Uncertain significance Single submitter
- SPSB3 p.Glu190Lys Uncertain significance Single submitter
- SPSB3 p.Glu343Lys Uncertain significance Single submitter
- SPSB3 p.Gly167Asp Uncertain significance Single submitter
- SPSB3 p.Gly229Ser Uncertain significance Single submitter
- SPSB3 p.Gly298Ser Uncertain significance Single submitter
- SPSB3 p.Gly31Ala Uncertain significance Single submitter
- SPSB3 p.Gly31Val Uncertain significance Single submitter
- SPSB3 p.Gly41Arg Uncertain significance Single submitter
- SPSB3 p.His223Asp Uncertain significance Single submitter
- SPSB3 p.Ile240Met Uncertain significance Single submitter
- SPSB3 p.Leu309Pro Uncertain significance Single submitter
- SPSB3 p.Leu317Pro Uncertain significance Single submitter
- SPSB3 p.Leu55Pro Uncertain significance Single submitter
- SPSB3 p.Lys204Asn Uncertain significance Single submitter
- SPSB3 p.Met319Thr Uncertain significance Single submitter
- SPSB3 p.Phe214Leu Uncertain significance Single submitter
- SPSB3 p.Pro254Leu Uncertain significance Single submitter
- SPSB3 p.Pro300Leu Uncertain significance Single submitter
- SPSB3 p.Pro344Leu Uncertain significance Single submitter
- SPSB3 p.Pro346Leu Uncertain significance Single submitter
- SPSB3 p.Ser292Leu Uncertain significance Single submitter
- SPSB3 p.Ser322Asn Uncertain significance Single submitter
- SPSB3 p.Ser329Cys Uncertain significance Single submitter
- SPSB3 p.Ser53Cys Uncertain significance Single submitter
- SPSB3 p.Ser80Tyr Uncertain significance Single submitter
- SPSB3 p.Thr156Ile Uncertain significance Single submitter
- SPSB3 p.Thr181Met Uncertain significance Single submitter
- SPSB3 p.Thr275Ser Uncertain significance Single submitter
- SPSB3 p.Thr295Met Uncertain significance Single submitter
- SPSB3 p.Thr66Ser Uncertain significance Single submitter
- SPSB3 p.Trp35Arg Uncertain significance Single submitter
- SPSB3 p.Val308Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- SPSB3 p.Arg289Trp Uncertain significance Single submitter
- SPSB3 p.Lys250Asn Uncertain significance Single submitter
- SPSB3 p.Met155Ile Uncertain significance Single submitter
- SPSB3 p.Met155Val Uncertain significance Single submitter
- SPSB3 p.Ser16Arg Uncertain significance Single submitter
- SPSB3 p.Ser46Trp Uncertain significance Single submitter
- SPSB3 p.Ser69Phe Uncertain significance Single submitter
- SPSB3 p.Thr230Ile Uncertain significance Single submitter
- SPSB3 p.Val222Met Uncertain significance Single submitter
All SPSB3 variants
Benign 1
- p.Ala115= Multiple submitters
Likely benign 7
- p.Arg179His Single submitter
- p.Arg324His Single submitter
- p.Pro302= Single submitter
- p.Ser80Phe Single submitter
- p.Thr268Ile Single submitter
- p.Val173= Single submitter
- p.Val328Ala Single submitter
Uncertain significance 79
- p.Ala18Val Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala274Ser Single submitter ⚠
- p.Ala334Val Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Arg20Gly Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg289Trp Single submitter ⚠
- p.Arg323His Single submitter ⚠
- p.Arg324Gly Single submitter ⚠
- p.Arg342Gly Single submitter ⚠
- p.Arg353Gly Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Arg354Gln Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asp109Asn Single submitter ⚠
- p.Asp163Asn Single submitter ⚠
- p.Asp174Asn Single submitter ⚠
- p.Asp206His Single submitter ⚠
- p.Asp291Asn Single submitter ⚠
- p.Asp330Asn Single submitter ⚠
- p.Asp330His Single submitter ⚠
- p.Asp45Asn Single submitter ⚠
- p.Asp93Gly Single submitter ⚠
- p.Cys120Phe Single submitter ⚠
- p.Cys120Tyr Single submitter ⚠
- p.Cys239Arg Single submitter
- p.Cys257Ser Single submitter
- p.Cys271Trp Single submitter ⚠
- p.Cys352Arg Single submitter ⚠
- p.Cys73Ser Single submitter ⚠
- p.Cys82Tyr Single submitter ⚠
- p.Gln216Arg Single submitter
- p.Gln248Arg Single submitter ⚠
- p.Gln348His Single submitter ⚠
- p.Glu190Lys Single submitter ⚠
- p.Glu343Lys Single submitter ⚠
- p.Gly167Asp Single submitter ⚠
- p.Gly215Ser Single submitter
- p.Gly229Ser Single submitter ⚠
- p.Gly298Ser Single submitter ⚠
- p.Gly31Ala Single submitter ⚠
- p.Gly31Val Single submitter ⚠
- p.Gly41Arg Single submitter ⚠
- p.His223Asp Single submitter ⚠
- p.Ile240Met Single submitter ⚠
- p.Leu309Pro Single submitter ⚠
- p.Leu317Pro Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Lys204Asn Single submitter ⚠
- p.Lys250Asn Single submitter ⚠
- p.Met155Ile Single submitter ⚠
- p.Met155Val Single submitter ⚠
- p.Met319Thr Single submitter ⚠
- p.Phe214Leu Single submitter ⚠
- p.Pro254Leu Single submitter ⚠
- p.Pro300Leu Single submitter ⚠
- p.Pro344Leu Single submitter ⚠
- p.Pro346Leu Single submitter ⚠
- p.Pro60Leu Single submitter
- p.Ser16Arg Single submitter ⚠
- p.Ser218Thr Single submitter
- p.Ser292Leu Single submitter ⚠
- p.Ser322Asn Single submitter ⚠
- p.Ser329Cys Single submitter ⚠
- p.Ser46Trp Single submitter ⚠
- p.Ser53Cys Single submitter ⚠
- p.Ser69Phe Single submitter ⚠
- p.Ser80Tyr Single submitter ⚠
- p.Thr156Ile Single submitter ⚠
- p.Thr181Met Single submitter ⚠
- p.Thr230Ile Single submitter ⚠
- p.Thr275Ser Single submitter ⚠
- p.Thr295Met Single submitter ⚠
- p.Thr66Ser Single submitter ⚠
- p.Trp35Arg Single submitter ⚠
- p.Val222Met Single submitter ⚠
- p.Val308Leu Single submitter ⚠