SRPRB — 36 ClinVar variants
All ClinVar germline SRPRB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Conflicting · 1 Benign · 34 Uncertain significance
Full SRPRB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SRPRB p.Ala211Val Uncertain significance Single submitter
- SRPRB p.Arg109Lys Uncertain significance Single submitter
- SRPRB p.Arg150Gln Uncertain significance Single submitter
- SRPRB p.Arg58Gln Uncertain significance Single submitter
- SRPRB p.Asn106Ser Uncertain significance Single submitter
- SRPRB p.Asn171Ser Uncertain significance Single submitter
- SRPRB p.Asn171Thr Uncertain significance Single submitter
- SRPRB p.Asp91Glu Uncertain significance Single submitter
- SRPRB p.Cys100Tyr Uncertain significance Single submitter
- SRPRB p.Cys246Tyr Uncertain significance Single submitter
- SRPRB p.Gln261Glu Uncertain significance Single submitter
- SRPRB p.Gln64Pro Uncertain significance Single submitter
- SRPRB p.Glu130Gln Uncertain significance Single submitter
- SRPRB p.Glu233Gln Uncertain significance Single submitter
- SRPRB p.Glu242Asp Uncertain significance Single submitter
- SRPRB p.Ile164Thr Uncertain significance Single submitter
- SRPRB p.Leu204Phe Uncertain significance Single submitter
- SRPRB p.Ser219Asn Uncertain significance Single submitter
- SRPRB p.Ser59Asn Uncertain significance Single submitter
- SRPRB p.Ser62Gly Uncertain significance Single submitter
- SRPRB p.Ser99Asn Uncertain significance Single submitter
- SRPRB p.Val102Ile Uncertain significance Single submitter
- SRPRB p.Val206Ala Uncertain significance Single submitter
- SRPRB p.Val255Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SRPRB p.Arg208His Uncertain significance Single submitter
- SRPRB p.Asp259Tyr Uncertain significance Single submitter
- SRPRB p.Glu200Asp Conflicting Single submitter
- SRPRB p.Ile116Thr Uncertain significance Single submitter
- SRPRB p.Ser134Cys Uncertain significance Single submitter
- SRPRB p.Ser235Pro Uncertain significance Single submitter
- SRPRB p.Trp54Arg Uncertain significance Single submitter
All SRPRB variants
Conflicting classifications of pathogenicity 1
- p.Glu200Asp Single submitter ⚠
Benign 1
- p.Val105= Single submitter
Uncertain significance 34
- p.Ala211Val Single submitter ⚠
- p.Arg109Lys Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg208His Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Asn106Ser Single submitter ⚠
- p.Asn171Ser Single submitter ⚠
- p.Asn171Thr Single submitter ⚠
- p.Asp259Tyr Single submitter ⚠
- p.Asp91Glu Single submitter ⚠
- p.Cys100Tyr Single submitter ⚠
- p.Cys246Tyr Single submitter ⚠
- p.Cys73Gly Single submitter
- p.Gln261Glu Single submitter ⚠
- p.Gln64Pro Single submitter ⚠
- p.Glu130Gln Single submitter ⚠
- p.Glu233Gln Single submitter ⚠
- p.Glu242Asp Single submitter ⚠
- p.Ile116Thr Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Leu204Phe Single submitter ⚠
- p.Ser134Cys Single submitter ⚠
- p.Ser219Asn Single submitter ⚠
- p.Ser235Pro Single submitter ⚠
- p.Ser59Asn Single submitter ⚠
- p.Ser62Gly Single submitter ⚠
- p.Ser99Asn Single submitter ⚠
- p.Thr94Met Single submitter
- p.Trp54Arg Single submitter ⚠
- p.Tyr160Cys Single submitter
- p.Tyr160His Single submitter
- p.Val102Ile Single submitter ⚠
- p.Val206Ala Single submitter ⚠
- p.Val255Met Single submitter ⚠