SRR — 34 ClinVar variants
All ClinVar germline SRR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Likely benign · 33 Uncertain significance
Full SRR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SRR p.Arg58His Uncertain significance Single submitter
- SRR p.Arg58Pro Uncertain significance Single submitter
- SRR p.Asp258Gly Uncertain significance Single submitter
- SRR p.Gln296Glu Uncertain significance Single submitter
- SRR p.Gln296His Uncertain significance Single submitter
- SRR p.Gly192Ala Uncertain significance Single submitter
- SRR p.Gly245Asp Uncertain significance Single submitter
- SRR p.Ile118Thr Uncertain significance Single submitter
- SRR p.Ile193Thr Uncertain significance Single submitter
- SRR p.Ile259Asn Uncertain significance Single submitter
- SRR p.Leu176Phe Uncertain significance Single submitter
- SRR p.Pro130Ser Uncertain significance Single submitter
- SRR p.Pro303Leu Uncertain significance Single submitter
- SRR p.Ser295Pro Uncertain significance Single submitter
- SRR p.Ser334Ala Uncertain significance Single submitter
- SRR p.Thr300Ala Uncertain significance Single submitter
- SRR p.Thr324Ser Uncertain significance Single submitter
- SRR p.Val301Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- SRR p.Ala167Thr Uncertain significance Single submitter
- SRR p.Asp257Asn Uncertain significance Single submitter
- SRR p.Glu304Gln Uncertain significance Single submitter
- SRR p.Gly224Arg Uncertain significance Single submitter
- SRR p.Ile23Thr Uncertain significance Single submitter
- SRR p.Leu37Val Likely benign Single submitter
- SRR p.Met150Ile Uncertain significance Single submitter
- SRR p.Phe49Leu Uncertain significance Single submitter
- SRR p.Pro111Leu Uncertain significance Single submitter
- SRR p.Pro202Leu Uncertain significance Single submitter
- SRR p.Pro232Ser Uncertain significance Single submitter
- SRR p.Ser313Gly Uncertain significance Single submitter
- SRR p.Ser337Phe Uncertain significance Single submitter
- SRR p.Tyr207Cys Uncertain significance Single submitter
- SRR p.Val174Phe Uncertain significance Single submitter
- SRR p.Val204Met Uncertain significance Single submitter
All SRR variants
Likely benign 1
- p.Leu37Val Single submitter ⚠
Uncertain significance 33
- p.Ala167Thr Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Arg58Pro Single submitter ⚠
- p.Asp257Asn Single submitter ⚠
- p.Asp258Gly Single submitter ⚠
- p.Gln296Glu Single submitter ⚠
- p.Gln296His Single submitter ⚠
- p.Glu304Gln Single submitter ⚠
- p.Gly192Ala Single submitter ⚠
- p.Gly224Arg Single submitter ⚠
- p.Gly245Asp Single submitter ⚠
- p.Ile118Thr Single submitter ⚠
- p.Ile193Thr Single submitter ⚠
- p.Ile23Thr Single submitter ⚠
- p.Ile259Asn Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Met150Ile Single submitter ⚠
- p.Phe49Leu Single submitter ⚠
- p.Pro111Leu Single submitter ⚠
- p.Pro130Ser Single submitter ⚠
- p.Pro202Leu Single submitter ⚠
- p.Pro232Ser Single submitter ⚠
- p.Pro303Leu Single submitter ⚠
- p.Ser295Pro Single submitter ⚠
- p.Ser313Gly Single submitter ⚠
- p.Ser334Ala Single submitter ⚠
- p.Ser337Phe Single submitter ⚠
- p.Thr300Ala Single submitter ⚠
- p.Thr324Ser Single submitter ⚠
- p.Tyr207Cys Single submitter ⚠
- p.Val174Phe Single submitter ⚠
- p.Val204Met Single submitter ⚠
- p.Val301Ile Single submitter ⚠