SRSF9 — 9 ClinVar variants
All ClinVar germline SRSF9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
1 Benign · 8 Uncertain significance
Full SRSF9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SRSF9 p.Arg202His Uncertain significance Single submitter
- SRSF9 p.Glu185Gln Uncertain significance Single submitter
- SRSF9 p.Ile69Val Uncertain significance Single submitter
- SRSF9 p.Phe215Tyr Uncertain significance Single submitter
- SRSF9 p.Thr188Ala Uncertain significance Single submitter
- SRSF9 p.Tyr90Cys Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All SRSF9 variants
Benign 1
- p.Ala65= Single submitter
Uncertain significance 8
- p.Arg202His Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Glu185Gln Single submitter ⚠
- p.His130Tyr Single submitter ⚠
- p.Ile69Val Single submitter ⚠
- p.Phe215Tyr Single submitter ⚠
- p.Thr188Ala Single submitter ⚠
- p.Tyr90Cys Single submitter ⚠