SSTR2 — 41 ClinVar variants
All ClinVar germline SSTR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
3 Likely benign · 38 Uncertain significance
Full SSTR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SSTR2 p.Arg157Gln Uncertain significance Single submitter
- SSTR2 p.Arg184Gln Uncertain significance Single submitter
- SSTR2 p.Arg340Gln Uncertain significance Single submitter
- SSTR2 p.Asn22Ser Uncertain significance Single submitter
- SSTR2 p.Asn318Ser Uncertain significance Single submitter
- SSTR2 p.Asn325Lys Uncertain significance Single submitter
- SSTR2 p.Asn9Ser Uncertain significance Single submitter
- SSTR2 p.Asp337His Uncertain significance Single submitter
- SSTR2 p.Cys193Ser Uncertain significance Single submitter
- SSTR2 p.Gly60Arg Uncertain significance Single submitter
- SSTR2 p.His12Tyr Uncertain significance Single submitter
- SSTR2 p.His146Asn Uncertain significance Single submitter
- SSTR2 p.Ile17Val Uncertain significance Single submitter
- SSTR2 p.Ile210Val Uncertain significance Single submitter
- SSTR2 p.Ile240Asn Uncertain significance Single submitter
- SSTR2 p.Ile55Thr Uncertain significance Single submitter
- SSTR2 p.Ile87Val Uncertain significance Single submitter
- SSTR2 p.Leu21Phe Uncertain significance Single submitter
- SSTR2 p.Leu226Phe Uncertain significance Single submitter
- SSTR2 p.Leu361Ile Uncertain significance Single submitter
- SSTR2 p.Lys248Arg Uncertain significance Single submitter
- SSTR2 p.Met101Val Uncertain significance Single submitter
- SSTR2 p.Met164Leu Uncertain significance Single submitter
- SSTR2 p.Phe48Leu Uncertain significance Single submitter
- SSTR2 p.Ser245Pro Uncertain significance Single submitter
- SSTR2 p.Ser343Thr Uncertain significance Single submitter
- SSTR2 p.Thr30Asn Uncertain significance Single submitter
- SSTR2 p.Thr353Ala Uncertain significance Single submitter
- SSTR2 p.Thr353Ile Uncertain significance Single submitter
- SSTR2 p.Thr354Met Uncertain significance Single submitter
- SSTR2 p.Thr359Ile Uncertain significance Single submitter
- SSTR2 p.Thr359Ser Uncertain significance Single submitter
- SSTR2 p.Trp188Ser Uncertain significance Single submitter
- SSTR2 p.Tyr302Cys Uncertain significance Single submitter
- SSTR2 p.Val173Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All SSTR2 variants
Likely benign 3
- p.Ala4Val Single submitter
- p.His12Gln Single submitter
- p.Ile87= Single submitter
Uncertain significance 38
- p.Ala181Val Single submitter ⚠
- p.Arg157Gln Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg340Gln Single submitter ⚠
- p.Asn22Ser Single submitter ⚠
- p.Asn318Ser Single submitter ⚠
- p.Asn325Lys Single submitter ⚠
- p.Asn9Ser Single submitter ⚠
- p.Asp337His Single submitter ⚠
- p.Cys193Ser Single submitter ⚠
- p.Gly60Arg Single submitter ⚠
- p.His12Tyr Single submitter ⚠
- p.His146Asn Single submitter ⚠
- p.Ile17Val Single submitter ⚠
- p.Ile210Val Single submitter ⚠
- p.Ile240Asn Single submitter ⚠
- p.Ile55Thr Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu21Phe Single submitter ⚠
- p.Leu226Phe Single submitter ⚠
- p.Leu361Ile Single submitter ⚠
- p.Lys248Arg Single submitter ⚠
- p.Met101Val Single submitter ⚠
- p.Met164Leu Single submitter ⚠
- p.Phe48Leu Single submitter ⚠
- p.Pro288Leu Single submitter ⚠
- p.Ser245Pro Single submitter ⚠
- p.Ser343Thr Single submitter ⚠
- p.Thr30Asn Single submitter ⚠
- p.Thr353Ala Single submitter ⚠
- p.Thr353Ile Single submitter ⚠
- p.Thr354Met Single submitter ⚠
- p.Thr359Ile Single submitter ⚠
- p.Thr359Ser Single submitter ⚠
- p.Trp188Ser Single submitter ⚠
- p.Tyr302Cys Single submitter ⚠
- p.Val145Ile Single submitter
- p.Val173Ile Single submitter ⚠