SSTR3 — 78 ClinVar variants
All ClinVar germline SSTR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
5 Likely benign · 73 Uncertain significance
Full SSTR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SSTR3 p.Ala157Pro Uncertain significance Single submitter
- SSTR3 p.Ala170Val Uncertain significance Single submitter
- SSTR3 p.Ala172Val Uncertain significance Single submitter
- SSTR3 p.Ala200Val Uncertain significance Single submitter
- SSTR3 p.Ala264Val Uncertain significance Single submitter
- SSTR3 p.Ala74Asp Uncertain significance Single submitter
- SSTR3 p.Arg153Cys Uncertain significance Single submitter
- SSTR3 p.Arg155His Uncertain significance Single submitter
- SSTR3 p.Arg161Cys Uncertain significance Single submitter
- SSTR3 p.Arg186Cys Uncertain significance Single submitter
- SSTR3 p.Arg234His Uncertain significance Single submitter
- SSTR3 p.Arg238Cys Uncertain significance Single submitter
- SSTR3 p.Arg247Trp Uncertain significance Single submitter
- SSTR3 p.Arg330Trp Uncertain significance Single submitter
- SSTR3 p.Arg333Cys Uncertain significance Single submitter
- SSTR3 p.Arg334His Uncertain significance Single submitter
- SSTR3 p.Arg373Gln Uncertain significance Single submitter
- SSTR3 p.Arg373Trp Uncertain significance Single submitter
- SSTR3 p.Arg387Trp Uncertain significance Single submitter
- SSTR3 p.Glu288Lys Uncertain significance Single submitter
- SSTR3 p.Glu353Gly Uncertain significance Single submitter
- SSTR3 p.Glu354Gly Uncertain significance Single submitter
- SSTR3 p.Glu91Lys Uncertain significance Single submitter
- SSTR3 p.Gly29Ser Uncertain significance Single submitter
- SSTR3 p.Gly372Ser Uncertain significance Single submitter
- SSTR3 p.Gly381Asp Uncertain significance Single submitter
- SSTR3 p.Gly61Ser Uncertain significance Single submitter
- SSTR3 p.His5Leu Uncertain significance Single submitter
- SSTR3 p.Ile222Asn Uncertain significance Single submitter
- SSTR3 p.Leu297Val Uncertain significance Single submitter
- SSTR3 p.Leu59Arg Uncertain significance Single submitter
- SSTR3 p.Leu86Val Uncertain significance Single submitter
- SSTR3 p.Pro158Leu Uncertain significance Single submitter
- SSTR3 p.Pro23Ser Uncertain significance Single submitter
- SSTR3 p.Pro388Leu Uncertain significance Single submitter
- SSTR3 p.Ser306Asn Uncertain significance Single submitter
- SSTR3 p.Ser7Thr Uncertain significance Single submitter
- SSTR3 p.Ser8Leu Uncertain significance Single submitter
- SSTR3 p.Thr11Met Uncertain significance Single submitter
- SSTR3 p.Thr210Met Uncertain significance Single submitter
- SSTR3 p.Thr378Met Uncertain significance Single submitter
- SSTR3 p.Thr406Ile Uncertain significance Single submitter
- SSTR3 p.Thr412Met Uncertain significance Single submitter
- SSTR3 p.Thr79Asn Uncertain significance Single submitter
- SSTR3 p.Tyr303Ser Uncertain significance Single submitter
- SSTR3 p.Tyr82Cys Uncertain significance Single submitter
- SSTR3 p.Val139Met Uncertain significance Single submitter
- SSTR3 p.Val145Met Uncertain significance Single submitter
- SSTR3 p.Val179Leu Uncertain significance Single submitter
- SSTR3 p.Val260Leu Uncertain significance Single submitter
- SSTR3 p.Val31Glu Uncertain significance Single submitter
- SSTR3 p.Val342Leu Uncertain significance Single submitter
- SSTR3 p.Val81Ile Uncertain significance Single submitter
- SSTR3 p.Val81Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- SSTR3 p.Arg150Cys Uncertain significance Single submitter
- SSTR3 p.Arg250His Likely benign Single submitter
- SSTR3 p.Arg319Cys Uncertain significance Single submitter
- SSTR3 p.Arg325His Uncertain significance Single submitter
- SSTR3 p.Arg71Gln Uncertain significance Single submitter
- SSTR3 p.Asp352Tyr Uncertain significance Single submitter
- SSTR3 p.Glu355Lys Uncertain significance Single submitter
- SSTR3 p.Gly112Ser Uncertain significance Single submitter
- SSTR3 p.Ile125Thr Uncertain significance Single submitter
- SSTR3 p.Phe181Leu Uncertain significance Single submitter
- SSTR3 p.Ser32Leu Uncertain significance Single submitter
- SSTR3 p.Ser63Leu Uncertain significance Single submitter
- SSTR3 p.Thr79Ala Uncertain significance Single submitter
- SSTR3 p.Val175Leu Uncertain significance Single submitter
- SSTR3 p.Val275Met Uncertain significance Single submitter
All SSTR3 variants
Likely benign 5
- p.Arg250His Single submitter ⚠
- p.Pro196= Single submitter
- p.Ser411Gly Single submitter
- p.Thr162Met Single submitter
- p.Val45Ile Single submitter
Uncertain significance 73
- p.Ala157Pro Single submitter ⚠
- p.Ala170Val Single submitter ⚠
- p.Ala172Val Single submitter ⚠
- p.Ala200Val Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala74Asp Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg161Cys Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg203Ter Single submitter
- p.Arg234His Single submitter ⚠
- p.Arg238Cys Single submitter ⚠
- p.Arg247Trp Single submitter ⚠
- p.Arg319Cys Single submitter ⚠
- p.Arg325His Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg333Cys Single submitter ⚠
- p.Arg334His Single submitter ⚠
- p.Arg373Gln Single submitter ⚠
- p.Arg373Trp Single submitter ⚠
- p.Arg387Trp Single submitter ⚠
- p.Arg71Gln Single submitter ⚠
- p.Asp352Tyr Single submitter ⚠
- p.Glu288Lys Single submitter ⚠
- p.Glu353Gly Single submitter ⚠
- p.Glu354Gly Single submitter ⚠
- p.Glu355Lys Single submitter ⚠
- p.Glu91Lys Single submitter ⚠
- p.Gly112Ser Single submitter ⚠
- p.Gly187Arg Single submitter
- p.Gly29Ser Single submitter ⚠
- p.Gly372Ser Single submitter ⚠
- p.Gly381Asp Single submitter ⚠
- p.Gly61Ser Single submitter ⚠
- p.His5Leu Single submitter ⚠
- p.Ile125Thr Single submitter ⚠
- p.Ile222Asn Single submitter ⚠
- p.Leu297Val Single submitter ⚠
- p.Leu59Arg Single submitter ⚠
- p.Leu86Val Single submitter ⚠
- p.Phe181Leu Single submitter ⚠
- p.Pro158Leu Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Pro388Leu Single submitter ⚠
- p.Ser306Asn Single submitter ⚠
- p.Ser32Leu Single submitter ⚠
- p.Ser63Leu Single submitter ⚠
- p.Ser7Thr Single submitter ⚠
- p.Ser8Leu Single submitter ⚠
- p.Thr11Met Single submitter ⚠
- p.Thr210Met Single submitter ⚠
- p.Thr378Met Single submitter ⚠
- p.Thr406Ile Single submitter ⚠
- p.Thr412Met Single submitter ⚠
- p.Thr79Ala Single submitter ⚠
- p.Thr79Asn Single submitter ⚠
- p.Thr79Ser Single submitter
- p.Tyr108Cys Single submitter
- p.Tyr303Ser Single submitter ⚠
- p.Tyr82Cys Single submitter ⚠
- p.Val139Met Single submitter ⚠
- p.Val145Met Single submitter ⚠
- p.Val175Leu Single submitter ⚠
- p.Val179Leu Single submitter ⚠
- p.Val260Leu Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val298Gly Single submitter
- p.Val31Glu Single submitter ⚠
- p.Val342Leu Single submitter ⚠
- p.Val81Ile Single submitter ⚠
- p.Val81Leu Single submitter ⚠