SSTR4 — 69 ClinVar variants
All ClinVar germline SSTR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
4 Benign · 3 Likely benign · 62 Uncertain significance
Full SSTR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SSTR4 p.Ala155Val Uncertain significance Single submitter
- SSTR4 p.Ala18Thr Uncertain significance Single submitter
- SSTR4 p.Ala240Val Uncertain significance Single submitter
- SSTR4 p.Ala28Ser Uncertain significance Single submitter
- SSTR4 p.Ala302Gly Uncertain significance Single submitter
- SSTR4 p.Ala302Ser Uncertain significance Single submitter
- SSTR4 p.Ala350Asp Uncertain significance Single submitter
- SSTR4 p.Ala42Ser Uncertain significance Single submitter
- SSTR4 p.Ala44Glu Uncertain significance Single submitter
- SSTR4 p.Ala44Val Uncertain significance Single submitter
- SSTR4 p.Arg110His Uncertain significance Single submitter
- SSTR4 p.Arg110Ser Uncertain significance Single submitter
- SSTR4 p.Arg250His Uncertain significance Single submitter
- SSTR4 p.Arg320Leu Uncertain significance Single submitter
- SSTR4 p.Arg324Gln Uncertain significance Single submitter
- SSTR4 p.Arg377Gly Uncertain significance Single submitter
- SSTR4 p.Arg377His Uncertain significance Single submitter
- SSTR4 p.Asp186Asn Uncertain significance Single submitter
- SSTR4 p.Asp93Asn Uncertain significance Single submitter
- SSTR4 p.Cys230Trp Uncertain significance Single submitter
- SSTR4 p.Cys366Tyr Uncertain significance Single submitter
- SSTR4 p.Gln367Pro Uncertain significance Single submitter
- SSTR4 p.Glu12Lys Uncertain significance Single submitter
- SSTR4 p.Glu342Gly Uncertain significance Single submitter
- SSTR4 p.Glu34Gln Uncertain significance Single submitter
- SSTR4 p.Glu34Val Uncertain significance Single submitter
- SSTR4 p.Gly335Ser Uncertain significance Single submitter
- SSTR4 p.Gly355Asp Uncertain significance Single submitter
- SSTR4 p.Gly358Glu Uncertain significance Single submitter
- SSTR4 p.Gly46Arg Uncertain significance Single submitter
- SSTR4 p.Leu371Pro Uncertain significance Single submitter
- SSTR4 p.Leu7Pro Uncertain significance Single submitter
- SSTR4 p.Met47Val Uncertain significance Single submitter
- SSTR4 p.Pro29Ala Uncertain significance Single submitter
- SSTR4 p.Pro343Leu Uncertain significance Single submitter
- SSTR4 p.Pro363Leu Uncertain significance Single submitter
- SSTR4 p.Ser208Leu Uncertain significance Single submitter
- SSTR4 p.Ser27Gly Uncertain significance Single submitter
- SSTR4 p.Ser99Thr Uncertain significance Single submitter
- SSTR4 p.Thr17Lys Uncertain significance Single submitter
- SSTR4 p.Thr215Ala Uncertain significance Single submitter
- SSTR4 p.Thr349Ser Uncertain significance Single submitter
- SSTR4 p.Val125Asp Uncertain significance Single submitter
- SSTR4 p.Val213Phe Uncertain significance Single submitter
- SSTR4 p.Val235Met Uncertain significance Single submitter
- SSTR4 p.Val266Phe Uncertain significance Single submitter
- SSTR4 p.Val285Gly Uncertain significance Single submitter
- SSTR4 p.Val285Leu Uncertain significance Single submitter
- SSTR4 p.Val48Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- SSTR4 p.Ala45Pro Uncertain significance Single submitter
- SSTR4 p.Arg252Ser Uncertain significance Single submitter
- SSTR4 p.Arg319Cys Uncertain significance Single submitter
- SSTR4 p.Asn199Lys Uncertain significance Single submitter
- SSTR4 p.Leu172Pro Uncertain significance Single submitter
- SSTR4 p.Met130Leu Uncertain significance Single submitter
- SSTR4 p.Phe114Leu Uncertain significance Single submitter
- SSTR4 p.Phe211Leu Uncertain significance Single submitter
- SSTR4 p.Ser300Arg Uncertain significance Single submitter
All SSTR4 variants
Benign 4
Likely benign 3
- p.Pro39Arg Single submitter
- p.Val266Ala Single submitter
- p.Val292Ile Single submitter
Uncertain significance 62
- p.Ala155Val Single submitter ⚠
- p.Ala18Thr Single submitter ⚠
- p.Ala240Val Single submitter ⚠
- p.Ala28Ser Single submitter ⚠
- p.Ala302Gly Single submitter ⚠
- p.Ala302Ser Single submitter ⚠
- p.Ala350Asp Single submitter ⚠
- p.Ala42Ser Single submitter ⚠
- p.Ala44Glu Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Ala45Pro Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg110Ser Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Arg252Ser Single submitter ⚠
- p.Arg319Cys Single submitter ⚠
- p.Arg320Leu Single submitter ⚠
- p.Arg324Gln Single submitter ⚠
- p.Arg377Gly Single submitter ⚠
- p.Arg377His Single submitter ⚠
- p.Asn199Lys Single submitter ⚠
- p.Asp186Asn Single submitter ⚠
- p.Asp93Asn Single submitter ⚠
- p.Cys230Trp Single submitter ⚠
- p.Cys366Tyr Single submitter ⚠
- p.Gln367Pro Single submitter ⚠
- p.Glu12Lys Single submitter ⚠
- p.Glu342Gly Single submitter ⚠
- p.Glu34Gln Single submitter ⚠
- p.Glu34Val Single submitter ⚠
- p.Gly193Cys Single submitter
- p.Gly335Ser Single submitter ⚠
- p.Gly355Asp Single submitter ⚠
- p.Gly358Glu Single submitter ⚠
- p.Gly46Arg Single submitter ⚠
- p.Leu172Pro Single submitter ⚠
- p.Leu371Pro Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Met130Leu Single submitter ⚠
- p.Met47Val Single submitter ⚠
- p.Phe114Leu Single submitter ⚠
- p.Phe211Leu Single submitter ⚠
- p.Phe216Ser Single submitter
- p.Pro29Ala Single submitter ⚠
- p.Pro343Leu Single submitter ⚠
- p.Pro363Leu Single submitter ⚠
- p.Ser208Leu Single submitter ⚠
- p.Ser253Trp Single submitter
- p.Ser27Gly Single submitter ⚠
- p.Ser300Arg Single submitter ⚠
- p.Ser99Thr Single submitter ⚠
- p.Thr17Lys Single submitter ⚠
- p.Thr215Ala Single submitter ⚠
- p.Thr349Ser Single submitter ⚠
- p.Tyr231Cys Single submitter
- p.Val125Asp Single submitter ⚠
- p.Val213Phe Single submitter ⚠
- p.Val235Met Single submitter ⚠
- p.Val266Phe Single submitter ⚠
- p.Val285Gly Single submitter ⚠
- p.Val285Leu Single submitter ⚠
- p.Val48Ile Single submitter ⚠