SSTR5 — 108 ClinVar variants
All ClinVar germline SSTR5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
12 Benign · 2 Benign/Likely benign · 12 Likely benign · 82 Uncertain significance
Full SSTR5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SSTR5 p.Thr98Met Uncertain significance Multiple submitters
- SSTR5 p.Ala159Val Uncertain significance Single submitter
- SSTR5 p.Ala162Thr Uncertain significance Single submitter
- SSTR5 p.Ala178Thr Uncertain significance Single submitter
- SSTR5 p.Ala188Thr Uncertain significance Single submitter
- SSTR5 p.Ala199Thr Uncertain significance Single submitter
- SSTR5 p.Ala212Thr Uncertain significance Single submitter
- SSTR5 p.Ala230Val Uncertain significance Single submitter
- SSTR5 p.Ala231Val Uncertain significance Single submitter
- SSTR5 p.Ala273Ser Uncertain significance Single submitter
- SSTR5 p.Ala283Thr Uncertain significance Single submitter
- SSTR5 p.Ala295Thr Uncertain significance Single submitter
- SSTR5 p.Ala330Thr Uncertain significance Single submitter
- SSTR5 p.Ala33Val Uncertain significance Single submitter
- SSTR5 p.Ala346Pro Uncertain significance Single submitter
- SSTR5 p.Ala353Thr Uncertain significance Single submitter
- SSTR5 p.Ala354Thr Uncertain significance Single submitter
- SSTR5 p.Ala40Val Uncertain significance Single submitter
- SSTR5 p.Ala85Thr Uncertain significance Single submitter
- SSTR5 p.Arg113Cys Uncertain significance Single submitter
- SSTR5 p.Arg137Cys Uncertain significance Single submitter
- SSTR5 p.Arg137His Uncertain significance Single submitter
- SSTR5 p.Arg149Cys Uncertain significance Single submitter
- SSTR5 p.Arg149His Uncertain significance Single submitter
- SSTR5 p.Arg154His Uncertain significance Single submitter
- SSTR5 p.Arg234His Uncertain significance Single submitter
- SSTR5 p.Arg244Gln Uncertain significance Single submitter
- SSTR5 p.Arg322Cys Uncertain significance Single submitter
- SSTR5 p.Arg322His Uncertain significance Single submitter
- SSTR5 p.Arg336Cys Uncertain significance Single submitter
- SSTR5 p.Arg352Cys Uncertain significance Single submitter
- SSTR5 p.Arg352His Uncertain significance Single submitter
- SSTR5 p.Arg39Gln Uncertain significance Single submitter
- SSTR5 p.Arg67His Uncertain significance Single submitter
- SSTR5 p.Asn310Ser Uncertain significance Single submitter
- SSTR5 p.Cys218Tyr Uncertain significance Single submitter
- SSTR5 p.Glu345Lys Uncertain significance Single submitter
- SSTR5 p.Gly183Ser Uncertain significance Single submitter
- SSTR5 p.Gly184Ser Uncertain significance Single submitter
- SSTR5 p.Gly284Ser Uncertain significance Single submitter
- SSTR5 p.Gly305Ser Uncertain significance Single submitter
- SSTR5 p.Ile224Met Uncertain significance Single submitter
- SSTR5 p.Leu114Pro Uncertain significance Single submitter
- SSTR5 p.Leu172Gln Uncertain significance Single submitter
- SSTR5 p.Leu196Pro Uncertain significance Single submitter
- SSTR5 p.Leu303Ile Uncertain significance Single submitter
- SSTR5 p.Leu364Pro Uncertain significance Single submitter
- SSTR5 p.Pro144Leu Uncertain significance Single submitter
- SSTR5 p.Pro173Leu Uncertain significance Single submitter
- SSTR5 p.Pro17Arg Uncertain significance Single submitter
- SSTR5 p.Pro17Leu Uncertain significance Single submitter
- SSTR5 p.Pro263Leu Uncertain significance Single submitter
- SSTR5 p.Pro32Gln Uncertain significance Single submitter
- SSTR5 p.Pro32Leu Uncertain significance Single submitter
- SSTR5 p.Ser103Phe Uncertain significance Single submitter
- SSTR5 p.Ser297Gly Uncertain significance Single submitter
- SSTR5 p.Ser35Leu Uncertain significance Single submitter
- SSTR5 p.Thr347Arg Uncertain significance Single submitter
- SSTR5 p.Thr9Ala Uncertain significance Single submitter
- SSTR5 p.Tyr286Cys Uncertain significance Single submitter
- SSTR5 p.Val141Met Uncertain significance Single submitter
- SSTR5 p.Val155Met Uncertain significance Single submitter
- SSTR5 p.Val194Met Uncertain significance Single submitter
- SSTR5 p.Val200Ile Uncertain significance Single submitter
- SSTR5 p.Val207Met Uncertain significance Single submitter
- SSTR5 p.Val225Met Uncertain significance Single submitter
- SSTR5 p.Val226Ala Uncertain significance Single submitter
- SSTR5 p.Val270Ile Uncertain significance Single submitter
- SSTR5 p.Val274Met Uncertain significance Single submitter
- SSTR5 p.Val302Ile Uncertain significance Single submitter
- SSTR5 p.Val45Met Uncertain significance Single submitter
- SSTR5 p.Val74Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SSTR5 p.Arg113His Uncertain significance Single submitter
- SSTR5 p.Arg241Cys Uncertain significance Single submitter
- SSTR5 p.Arg248His Uncertain significance Single submitter
- SSTR5 p.Arg67Cys Uncertain significance Single submitter
- SSTR5 p.Asn26His Uncertain significance Single submitter
- SSTR5 p.Cys169Arg Uncertain significance Single submitter
- SSTR5 p.Lys157Asn Uncertain significance Single submitter
- SSTR5 p.Lys72Glu Uncertain significance Single submitter
All SSTR5 variants
Benign 12
- p.Ala161= Multiple submitters
- p.Leu219= Multiple submitters
- p.Leu48Met Multiple submitters
- p.Phe107= Multiple submitters
- p.Pro335Leu Multiple submitters
- p.Ser134= Multiple submitters
- p.Ser147= Multiple submitters
- p.Ser171= Multiple submitters
- p.Thr333Met Multiple submitters
- p.Ser11= Single submitter
- p.Ala212= No assertion criteria SSTR5-related disorder
- p.Ala52= No assertion criteria SSTR5-related disorder
Benign/Likely benign 2
- p.Ala231= Multiple submitters
- p.Arg240Trp Multiple submitters
Likely benign 12
- p.Thr9Met Multiple submitters
- p.Ala14Thr Single submitter
- p.Ala350Thr Single submitter
- p.Ala353= Single submitter
- p.Arg352= Single submitter
- p.Asn100= Single submitter
- p.Leu196= Single submitter
- p.Thr247= Single submitter
- p.Thr98= Single submitter
- p.Val121Ile Single submitter
- p.Cys237= No assertion criteria SSTR5-related disorder
- p.Gly23= No assertion criteria SSTR5-related disorder
Uncertain significance 82
- p.Thr98Met Multiple submitters ⚠
- p.Ala159Val Single submitter ⚠
- p.Ala162Thr Single submitter ⚠
- p.Ala178Thr Single submitter ⚠
- p.Ala188Thr Single submitter ⚠
- p.Ala199Thr Single submitter ⚠
- p.Ala212Thr Single submitter ⚠
- p.Ala230Val Single submitter ⚠
- p.Ala231Val Single submitter ⚠
- p.Ala273Ser Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala295Thr Single submitter ⚠
- p.Ala330Thr Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Ala346Pro Single submitter ⚠
- p.Ala353Thr Single submitter ⚠
- p.Ala354Thr Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg154His Single submitter ⚠
- p.Arg234His Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg244Gln Single submitter ⚠
- p.Arg248His Single submitter ⚠
- p.Arg322Cys Single submitter ⚠
- p.Arg322His Single submitter ⚠
- p.Arg336Cys Single submitter ⚠
- p.Arg352Cys Single submitter ⚠
- p.Arg352His Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Arg67His Single submitter ⚠
- p.Asn26His Single submitter ⚠
- p.Asn310Ser Single submitter ⚠
- p.Cys169Arg Single submitter ⚠
- p.Cys218Tyr Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Gly183Ser Single submitter ⚠
- p.Gly184Ser Single submitter ⚠
- p.Gly284Ser Single submitter ⚠
- p.Gly305Ser Single submitter ⚠
- p.Ile224Met Single submitter ⚠
- p.Leu114Pro Single submitter ⚠
- p.Leu172Gln Single submitter ⚠
- p.Leu196Pro Single submitter ⚠
- p.Leu303Ile Single submitter ⚠
- p.Leu364Pro Single submitter ⚠
- p.Lys157Asn Single submitter ⚠
- p.Lys72Glu Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro17Arg Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro263Leu Single submitter ⚠
- p.Pro32Gln Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Ser103Phe Single submitter ⚠
- p.Ser242Leu Single submitter
- p.Ser297Gly Single submitter ⚠
- p.Ser35Leu Single submitter ⚠
- p.Thr347Arg Single submitter ⚠
- p.Thr9Ala Single submitter ⚠
- p.Tyr204Ser Single submitter
- p.Tyr286Cys Single submitter ⚠
- p.Val141Met Single submitter ⚠
- p.Val155Met Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val200Ile Single submitter ⚠
- p.Val207Met Single submitter ⚠
- p.Val225Met Single submitter ⚠
- p.Val226Ala Single submitter ⚠
- p.Val270Ile Single submitter ⚠
- p.Val274Met Single submitter ⚠
- p.Val302Ile Single submitter ⚠
- p.Val45Met Single submitter ⚠
- p.Val74Ile Single submitter ⚠