ST6GAL1 — 26 ClinVar variants
All ClinVar germline ST6GAL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
26 Uncertain significance
Full ST6GAL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ST6GAL1 p.Ala139Thr Uncertain significance Single submitter
- ST6GAL1 p.Ala207Ser Uncertain significance Single submitter
- ST6GAL1 p.Arg141Cys Uncertain significance Single submitter
- ST6GAL1 p.Asn250His Uncertain significance Single submitter
- ST6GAL1 p.Asn250Ser Uncertain significance Single submitter
- ST6GAL1 p.Asn272His Uncertain significance Single submitter
- ST6GAL1 p.Asp157His Uncertain significance Single submitter
- ST6GAL1 p.Glu166Lys Uncertain significance Single submitter
- ST6GAL1 p.Glu172Lys Uncertain significance Single submitter
- ST6GAL1 p.Gly385Asp Uncertain significance Single submitter
- ST6GAL1 p.His205Arg Uncertain significance Single submitter
- ST6GAL1 p.His263Arg Uncertain significance Single submitter
- ST6GAL1 p.Ile23Met Uncertain significance Single submitter
- ST6GAL1 p.Ile23Thr Uncertain significance Single submitter
- ST6GAL1 p.Ile253Thr Uncertain significance Single submitter
- ST6GAL1 p.Ile329Thr Uncertain significance Single submitter
- ST6GAL1 p.Leu231Val Uncertain significance Single submitter
- ST6GAL1 p.Lys127Arg Uncertain significance Single submitter
- ST6GAL1 p.Pro71Leu Uncertain significance Single submitter
- ST6GAL1 p.Ser346Thr Uncertain significance Single submitter
- ST6GAL1 p.Ser80Asn Uncertain significance Single submitter
- ST6GAL1 p.Thr227Asn Uncertain significance Single submitter
- ST6GAL1 p.Thr333Ala Uncertain significance Single submitter
- ST6GAL1 p.Thr397Ile Uncertain significance Single submitter
- ST6GAL1 p.Val223Met Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All ST6GAL1 variants
Uncertain significance 26
- p.Ala139Thr Single submitter ⚠
- p.Ala207Ser Single submitter ⚠
- p.Arg141Cys Single submitter ⚠
- p.Arg230His Single submitter ⚠
- p.Asn250His Single submitter ⚠
- p.Asn250Ser Single submitter ⚠
- p.Asn272His Single submitter ⚠
- p.Asp157His Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu172Lys Single submitter ⚠
- p.Gly385Asp Single submitter ⚠
- p.His205Arg Single submitter ⚠
- p.His263Arg Single submitter ⚠
- p.Ile23Met Single submitter ⚠
- p.Ile23Thr Single submitter ⚠
- p.Ile253Thr Single submitter ⚠
- p.Ile329Thr Single submitter ⚠
- p.Leu231Val Single submitter ⚠
- p.Lys127Arg Single submitter ⚠
- p.Pro71Leu Single submitter ⚠
- p.Ser346Thr Single submitter ⚠
- p.Ser80Asn Single submitter ⚠
- p.Thr227Asn Single submitter ⚠
- p.Thr333Ala Single submitter ⚠
- p.Thr397Ile Single submitter ⚠
- p.Val223Met Single submitter ⚠