Sugi Variant

Sugi Variant/STAG2

STAG2 — 774 ClinVar variants

All ClinVar germline STAG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 285 flagged for review →

24 Pathogenic · 2 Pathogenic/Likely pathogenic · 25 Likely pathogenic · 8 Conflicting · 62 Benign · 34 Benign/Likely benign · 280 Likely benign · 339 Uncertain significance

Full STAG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 285

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 185

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 185

Predictors split 92

The independent predictors disagree with each other — read with care.

All STAG2 variants

Pathogenic 24

Pathogenic/Likely pathogenic 2

Likely pathogenic 25

Conflicting classifications of pathogenicity 8

Benign 62

Benign/Likely benign 34

Likely benign 280

Uncertain significance 339

Showing the top 300 by review status; the full set is in the sitemap.