STARD3 — 66 ClinVar variants
All ClinVar germline STARD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Benign · 7 Likely benign · 58 Uncertain significance
Full STARD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STARD3 p.Ala187Thr Uncertain significance Single submitter
- STARD3 p.Ala293Val Uncertain significance Single submitter
- STARD3 p.Ala394Ser Uncertain significance Single submitter
- STARD3 p.Ala443Ser Uncertain significance Single submitter
- STARD3 p.Arg105Cys Uncertain significance Single submitter
- STARD3 p.Arg14Gly Uncertain significance Single submitter
- STARD3 p.Arg14His Uncertain significance Single submitter
- STARD3 p.Arg193Cys Uncertain significance Single submitter
- STARD3 p.Arg398Cys Uncertain significance Single submitter
- STARD3 p.Arg398His Uncertain significance Single submitter
- STARD3 p.Arg413Cys Uncertain significance Single submitter
- STARD3 p.Arg416Trp Uncertain significance Single submitter
- STARD3 p.Arg435Gln Uncertain significance Single submitter
- STARD3 p.Arg437Cys Uncertain significance Single submitter
- STARD3 p.Arg43Gln Uncertain significance Single submitter
- STARD3 p.Arg444Gln Uncertain significance Single submitter
- STARD3 p.Arg50His Uncertain significance Single submitter
- STARD3 p.Arg51Leu Uncertain significance Single submitter
- STARD3 p.Arg79Cys Uncertain significance Single submitter
- STARD3 p.Arg79His Uncertain significance Single submitter
- STARD3 p.Asp48Asn Uncertain significance Single submitter
- STARD3 p.Cys54Ser Uncertain significance Single submitter
- STARD3 p.Gln251Glu Uncertain significance Single submitter
- STARD3 p.Glu13Asp Uncertain significance Single submitter
- STARD3 p.Glu305Lys Uncertain significance Single submitter
- STARD3 p.Glu7Val Uncertain significance Single submitter
- STARD3 p.Glu83Gln Uncertain significance Single submitter
- STARD3 p.Gly200Ser Uncertain significance Single submitter
- STARD3 p.Gly364Glu Uncertain significance Single submitter
- STARD3 p.His35Tyr Uncertain significance Single submitter
- STARD3 p.Ile301Thr Uncertain significance Single submitter
- STARD3 p.Ile365Met Uncertain significance Single submitter
- STARD3 p.Ile98Thr Uncertain significance Single submitter
- STARD3 p.Leu289Pro Uncertain significance Single submitter
- STARD3 p.Lys147Thr Uncertain significance Single submitter
- STARD3 p.Lys92Glu Uncertain significance Single submitter
- STARD3 p.Ser158Phe Uncertain significance Single submitter
- STARD3 p.Ser33Thr Uncertain significance Single submitter
- STARD3 p.Ser393Leu Uncertain significance Single submitter
- STARD3 p.Val157Ile Uncertain significance Single submitter
- STARD3 p.Val19Met Uncertain significance Single submitter
- STARD3 p.Val225Ala Uncertain significance Single submitter
- STARD3 p.Val333Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- STARD3 p.Arg240Cys Uncertain significance Single submitter
- STARD3 p.Cys291Arg Uncertain significance Single submitter
- STARD3 p.Gly200Cys Uncertain significance Single submitter
- STARD3 p.Leu164Trp Uncertain significance Single submitter
- STARD3 p.Phe104Leu Uncertain significance Single submitter
- STARD3 p.Phe99Ser Uncertain significance Single submitter
- STARD3 p.Pro155Leu Uncertain significance Single submitter
- STARD3 p.Pro373Leu Uncertain significance Single submitter
- STARD3 p.Pro397Leu Uncertain significance Single submitter
- STARD3 p.Thr375Met Uncertain significance Single submitter
- STARD3 p.Thr401Ile Uncertain significance Single submitter
- STARD3 p.Tyr208His Uncertain significance Single submitter
- STARD3 p.Val296Met Uncertain significance Single submitter
All STARD3 variants
Benign 1
- p.Ser199= Single submitter
Likely benign 7
- p.Ile239Val Single submitter
- p.Phe59= Single submitter
- p.Pro38Leu Single submitter
- p.Thr127= Single submitter
- p.Thr246Met Single submitter
- p.Val173= Single submitter
- p.Val403Ile Single submitter
Uncertain significance 58
- p.Ala187Thr Single submitter ⚠
- p.Ala293Val Single submitter ⚠
- p.Ala394Ser Single submitter ⚠
- p.Ala443Ser Single submitter ⚠
- p.Arg105Cys Single submitter ⚠
- p.Arg14Gly Single submitter ⚠
- p.Arg14His Single submitter ⚠
- p.Arg193Cys Single submitter ⚠
- p.Arg240Cys Single submitter ⚠
- p.Arg398Cys Single submitter ⚠
- p.Arg398His Single submitter ⚠
- p.Arg413Cys Single submitter ⚠
- p.Arg416Trp Single submitter ⚠
- p.Arg435Gln Single submitter ⚠
- p.Arg437Cys Single submitter ⚠
- p.Arg43Gln Single submitter ⚠
- p.Arg444Gln Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg51Leu Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Asp218Gly Single submitter
- p.Asp48Asn Single submitter ⚠
- p.Cys291Arg Single submitter ⚠
- p.Cys54Ser Single submitter ⚠
- p.Gln251Glu Single submitter ⚠
- p.Glu13Asp Single submitter ⚠
- p.Glu305Lys Single submitter ⚠
- p.Glu7Val Single submitter ⚠
- p.Glu83Gln Single submitter ⚠
- p.Gly200Cys Single submitter ⚠
- p.Gly200Ser Single submitter ⚠
- p.Gly364Glu Single submitter ⚠
- p.His35Tyr Single submitter ⚠
- p.Ile301Thr Single submitter ⚠
- p.Ile365Met Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Leu164Trp Single submitter ⚠
- p.Leu289Pro Single submitter ⚠
- p.Lys147Thr Single submitter ⚠
- p.Lys377Glu Single submitter
- p.Lys92Glu Single submitter ⚠
- p.Phe104Leu Single submitter ⚠
- p.Phe99Ser Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro397Leu Single submitter ⚠
- p.Ser158Phe Single submitter ⚠
- p.Ser33Thr Single submitter ⚠
- p.Ser393Leu Single submitter ⚠
- p.Thr375Met Single submitter ⚠
- p.Thr401Ile Single submitter ⚠
- p.Tyr208His Single submitter ⚠
- p.Val157Ile Single submitter ⚠
- p.Val19Met Single submitter ⚠
- p.Val225Ala Single submitter ⚠
- p.Val296Met Single submitter ⚠
- p.Val333Met Single submitter ⚠