STAU1 — 61 ClinVar variants
All ClinVar germline STAU1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Benign · 1 Likely benign · 59 Uncertain significance
Full STAU1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STAU1 p.Ala546Val Uncertain significance Single submitter
- STAU1 p.Ala68Thr Uncertain significance Single submitter
- STAU1 p.Arg168Gly Uncertain significance Single submitter
- STAU1 p.Arg196Gln Uncertain significance Single submitter
- STAU1 p.Arg196Trp Uncertain significance Single submitter
- STAU1 p.Arg206Gln Uncertain significance Single submitter
- STAU1 p.Arg342Cys Uncertain significance Single submitter
- STAU1 p.Arg457Gln Uncertain significance Single submitter
- STAU1 p.Asn106Ser Uncertain significance Single submitter
- STAU1 p.Asn10Lys Uncertain significance Single submitter
- STAU1 p.Asn139Asp Uncertain significance Single submitter
- STAU1 p.Asn182Ser Uncertain significance Single submitter
- STAU1 p.Asn343Thr Uncertain significance Single submitter
- STAU1 p.Asp438Gly Uncertain significance Single submitter
- STAU1 p.Glu302Asp Uncertain significance Single submitter
- STAU1 p.Glu562Lys Uncertain significance Single submitter
- STAU1 p.Gly284Arg Uncertain significance Single submitter
- STAU1 p.Gly312Ala Uncertain significance Single submitter
- STAU1 p.Gly378Arg Uncertain significance Single submitter
- STAU1 p.Gly389Ser Uncertain significance Single submitter
- STAU1 p.Gly535Ser Uncertain significance Single submitter
- STAU1 p.His483Arg Uncertain significance Single submitter
- STAU1 p.Ile272Val Uncertain significance Single submitter
- STAU1 p.Ile471Val Uncertain significance Single submitter
- STAU1 p.Ile51Met Uncertain significance Single submitter
- STAU1 p.Ile61Val Uncertain significance Single submitter
- STAU1 p.Lys219Asn Uncertain significance Single submitter
- STAU1 p.Lys437Arg Uncertain significance Single submitter
- STAU1 p.Met454Leu Uncertain significance Single submitter
- STAU1 p.Met99Thr Uncertain significance Single submitter
- STAU1 p.Phe439Ser Uncertain significance Single submitter
- STAU1 p.Phe439Val Uncertain significance Single submitter
- STAU1 p.Pro113Ser Uncertain significance Single submitter
- STAU1 p.Pro164Ser Uncertain significance Single submitter
- STAU1 p.Pro287Leu Uncertain significance Single submitter
- STAU1 p.Pro314Leu Uncertain significance Single submitter
- STAU1 p.Pro357Leu Uncertain significance Single submitter
- STAU1 p.Pro373Leu Uncertain significance Single submitter
- STAU1 p.Pro43Ser Uncertain significance Single submitter
- STAU1 p.Pro444Leu Uncertain significance Single submitter
- STAU1 p.Pro570Leu Uncertain significance Single submitter
- STAU1 p.Ser101Tyr Uncertain significance Single submitter
- STAU1 p.Ser278Arg Uncertain significance Single submitter
- STAU1 p.Ser409Asn Uncertain significance Single submitter
- STAU1 p.Ser465Leu Uncertain significance Single submitter
- STAU1 p.Ser531Ile Uncertain significance Single submitter
- STAU1 p.Thr102Ile Uncertain significance Single submitter
- STAU1 p.Thr487Ala Uncertain significance Single submitter
- STAU1 p.Tyr103Ser Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- STAU1 p.Ala449Asp Uncertain significance Single submitter
- STAU1 p.Gly282Ser Uncertain significance Single submitter
- STAU1 p.Gly463Ser Uncertain significance Single submitter
- STAU1 p.Pro489Ser Uncertain significance Single submitter
- STAU1 p.Ser18Arg Uncertain significance Single submitter
- STAU1 p.Ser63Phe Uncertain significance Single submitter
All STAU1 variants
Benign 1
- c.344+9T>G Multiple submitters
Likely benign 1
- p.Thr39Ala Single submitter
Uncertain significance 59
- p.Ala449Asp Single submitter ⚠
- p.Ala546Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Arg168Gly Single submitter ⚠
- p.Arg196Gln Single submitter ⚠
- p.Arg196Trp Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg342Cys Single submitter ⚠
- p.Arg457Gln Single submitter ⚠
- p.Arg457Ter Single submitter
- p.Asn106Ser Single submitter ⚠
- p.Asn10Lys Single submitter ⚠
- p.Asn139Asp Single submitter ⚠
- p.Asn182Ser Single submitter ⚠
- p.Asn343Thr Single submitter ⚠
- p.Asp438Gly Single submitter ⚠
- p.Gln9Ter Single submitter
- p.Glu302Asp Single submitter ⚠
- p.Glu562Lys Single submitter ⚠
- p.Gly282Ser Single submitter ⚠
- p.Gly284Arg Single submitter ⚠
- p.Gly312Ala Single submitter ⚠
- p.Gly378Arg Single submitter ⚠
- p.Gly389Ser Single submitter ⚠
- p.Gly463Ser Single submitter ⚠
- p.Gly535Ser Single submitter ⚠
- p.His483Arg Single submitter ⚠
- p.Ile272Val Single submitter ⚠
- p.Ile471Val Single submitter ⚠
- p.Ile51Met Single submitter ⚠
- p.Ile530Met Single submitter
- p.Ile61Val Single submitter ⚠
- p.Lys219Asn Single submitter ⚠
- p.Lys437Arg Single submitter ⚠
- p.Met213Leu Single submitter
- p.Met454Leu Single submitter ⚠
- p.Met99Thr Single submitter ⚠
- p.Phe439Ser Single submitter ⚠
- p.Phe439Val Single submitter ⚠
- p.Pro113Ser Single submitter ⚠
- p.Pro164Ser Single submitter ⚠
- p.Pro287Leu Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Pro357Leu Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro43Ser Single submitter ⚠
- p.Pro444Leu Single submitter ⚠
- p.Pro489Ser Single submitter ⚠
- p.Pro570Leu Single submitter ⚠
- p.Ser101Tyr Single submitter ⚠
- p.Ser18Arg Single submitter ⚠
- p.Ser278Arg Single submitter ⚠
- p.Ser409Asn Single submitter ⚠
- p.Ser465Leu Single submitter ⚠
- p.Ser531Ile Single submitter ⚠
- p.Ser63Phe Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Thr487Ala Single submitter ⚠
- p.Tyr103Ser Single submitter ⚠