STIM2 — 101 ClinVar variants
All ClinVar germline STIM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
101 Uncertain significance
Full STIM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STIM2 p.Ala535Ser Uncertain significance Single submitter
- STIM2 p.Ala569Val Uncertain significance Single submitter
- STIM2 p.Ala579Asp Uncertain significance Single submitter
- STIM2 p.Ala71Thr Uncertain significance Single submitter
- STIM2 p.Arg288His Uncertain significance Single submitter
- STIM2 p.Arg303Trp Uncertain significance Single submitter
- STIM2 p.Arg430Gln Uncertain significance Single submitter
- STIM2 p.Arg433His Uncertain significance Single submitter
- STIM2 p.Arg542Gln Uncertain significance Single submitter
- STIM2 p.Arg572Gln Uncertain significance Single submitter
- STIM2 p.Arg637Gln Uncertain significance Single submitter
- STIM2 p.Arg716Lys Uncertain significance Single submitter
- STIM2 p.Asn107Asp Uncertain significance Single submitter
- STIM2 p.Asn162Ser Uncertain significance Single submitter
- STIM2 p.Asn295Ser Uncertain significance Single submitter
- STIM2 p.Asn367Ser Uncertain significance Single submitter
- STIM2 p.Asn672Ser Uncertain significance Single submitter
- STIM2 p.Asp104Val Uncertain significance Single submitter
- STIM2 p.Asp116Tyr Uncertain significance Single submitter
- STIM2 p.Asp645His Uncertain significance Single submitter
- STIM2 p.Asp652Asn Uncertain significance Single submitter
- STIM2 p.Cys302Tyr Uncertain significance Single submitter
- STIM2 p.Cys725Arg Uncertain significance Single submitter
- STIM2 p.Gln527His Uncertain significance Single submitter
- STIM2 p.Gln73His Uncertain significance Single submitter
- STIM2 p.Gln78Arg Uncertain significance Single submitter
- STIM2 p.Glu585Ala Uncertain significance Single submitter
- STIM2 p.Glu615Lys Uncertain significance Single submitter
- STIM2 p.Glu98Lys Uncertain significance Single submitter
- STIM2 p.His537Tyr Uncertain significance Single submitter
- STIM2 p.His543Pro Uncertain significance Single submitter
- STIM2 p.His546Arg Uncertain significance Single submitter
- STIM2 p.His722Tyr Uncertain significance Single submitter
- STIM2 p.Ile219Phe Uncertain significance Single submitter
- STIM2 p.Ile445Val Uncertain significance Single submitter
- STIM2 p.Ile491Val Uncertain significance Single submitter
- STIM2 p.Ile720Val Uncertain significance Single submitter
- STIM2 p.Leu600Phe Uncertain significance Single submitter
- STIM2 p.Lys417Asn Uncertain significance Single submitter
- STIM2 p.Lys730Arg Uncertain significance Single submitter
- STIM2 p.Phe218Val Uncertain significance Single submitter
- STIM2 p.Pro210Thr Uncertain significance Single submitter
- STIM2 p.Pro211Leu Uncertain significance Single submitter
- STIM2 p.Pro211Ser Uncertain significance Single submitter
- STIM2 p.Pro521Leu Uncertain significance Single submitter
- STIM2 p.Pro521Ser Uncertain significance Single submitter
- STIM2 p.Pro538Leu Uncertain significance Single submitter
- STIM2 p.Pro541Leu Uncertain significance Single submitter
- STIM2 p.Ser181Tyr Uncertain significance Single submitter
- STIM2 p.Ser344Asn Uncertain significance Single submitter
- STIM2 p.Ser456Phe Uncertain significance Single submitter
- STIM2 p.Ser556Phe Uncertain significance Single submitter
- STIM2 p.Ser57Asn Uncertain significance Single submitter
- STIM2 p.Ser621Pro Uncertain significance Single submitter
- STIM2 p.Ser640Leu Uncertain significance Single submitter
- STIM2 p.Ser650Pro Uncertain significance Single submitter
- STIM2 p.Ser68Asn Uncertain significance Single submitter
- STIM2 p.Thr166Met Uncertain significance Single submitter
- STIM2 p.Thr236Lys Uncertain significance Single submitter
- STIM2 p.Thr236Met Uncertain significance Single submitter
- STIM2 p.Thr62Ser Uncertain significance Single submitter
- STIM2 p.Thr657Ile Uncertain significance Single submitter
- STIM2 p.Trp232Leu Uncertain significance Single submitter
- STIM2 p.Tyr571Phe Uncertain significance Single submitter
- STIM2 p.Val361Ala Uncertain significance Single submitter
- STIM2 p.Val492Met Uncertain significance Single submitter
- STIM2 p.Val654Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- STIM2 p.Ala272Thr Uncertain significance Single submitter
- STIM2 p.Arg514Cys Uncertain significance Single submitter
- STIM2 p.Arg516Cys Uncertain significance Single submitter
- STIM2 p.Arg694Cys Uncertain significance Single submitter
- STIM2 p.Arg694His Uncertain significance Single submitter
- STIM2 p.Arg694Leu Uncertain significance Single submitter
- STIM2 p.Asp116Asn Uncertain significance Single submitter
- STIM2 p.Asp160His Uncertain significance Single submitter
- STIM2 p.Glu139Lys Uncertain significance Single submitter
- STIM2 p.Glu155Lys Uncertain significance Single submitter
- STIM2 p.His118Arg Uncertain significance Single submitter
- STIM2 p.His134Arg Uncertain significance Single submitter
- STIM2 p.His411Tyr Uncertain significance Single submitter
- STIM2 p.Ile224Met Uncertain significance Single submitter
- STIM2 p.Ile737Val Uncertain significance Single submitter
- STIM2 p.Lys298Glu Uncertain significance Single submitter
- STIM2 p.Lys418Asn Uncertain significance Single submitter
- STIM2 p.Pro691Arg Uncertain significance Single submitter
- STIM2 p.Ser745Cys Uncertain significance Single submitter
- STIM2 p.Trp214Arg Uncertain significance Single submitter
- STIM2 p.Trp464Arg Uncertain significance Single submitter
- STIM2 p.Tyr475Cys Uncertain significance Single submitter
All STIM2 variants
Uncertain significance 101
- p.Ala272Thr Single submitter ⚠
- p.Ala535Ser Single submitter ⚠
- p.Ala569Val Single submitter ⚠
- p.Ala579Asp Single submitter ⚠
- p.Ala71Thr Single submitter ⚠
- p.Arg288Cys Single submitter
- p.Arg288His Single submitter ⚠
- p.Arg303Trp Single submitter ⚠
- p.Arg430Gln Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg514Cys Single submitter ⚠
- p.Arg514His Single submitter
- p.Arg516Cys Single submitter ⚠
- p.Arg516His Single submitter
- p.Arg542Gln Single submitter ⚠
- p.Arg572Gln Single submitter ⚠
- p.Arg637Gln Single submitter ⚠
- p.Arg694Cys Single submitter ⚠
- p.Arg694His Single submitter ⚠
- p.Arg694Leu Single submitter ⚠
- p.Arg716Lys Single submitter ⚠
- p.Asn107Asp Single submitter ⚠
- p.Asn162Ser Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn367Ser Single submitter ⚠
- p.Asn672Ser Single submitter ⚠
- p.Asp104Val Single submitter ⚠
- p.Asp116Asn Single submitter ⚠
- p.Asp116Tyr Single submitter ⚠
- p.Asp160His Single submitter ⚠
- p.Asp645His Single submitter ⚠
- p.Asp652Asn Single submitter ⚠
- p.Cys302Tyr Single submitter ⚠
- p.Cys725Arg Single submitter ⚠
- p.Gln371Arg Single submitter
- p.Gln494Arg Single submitter
- p.Gln527His Single submitter ⚠
- p.Gln73His Single submitter ⚠
- p.Gln78Arg Single submitter ⚠
- p.Glu139Lys Single submitter ⚠
- p.Glu147fs Single submitter
- p.Glu155Lys Single submitter ⚠
- p.Glu585Ala Single submitter ⚠
- p.Glu615Lys Single submitter ⚠
- p.Glu98Lys Single submitter ⚠
- p.Gly605Arg Single submitter
- p.His118Arg Single submitter ⚠
- p.His134Arg Single submitter ⚠
- p.His411Tyr Single submitter ⚠
- p.His537Tyr Single submitter ⚠
- p.His543Pro Single submitter ⚠
- p.His546Arg Single submitter ⚠
- p.His722Tyr Single submitter ⚠
- p.Ile119Val Single submitter
- p.Ile219Phe Single submitter ⚠
- p.Ile224Met Single submitter ⚠
- p.Ile445Val Single submitter ⚠
- p.Ile491Val Single submitter ⚠
- p.Ile720Val Single submitter ⚠
- p.Ile737Val Single submitter ⚠
- p.Leu454= Single submitter
- p.Leu600Phe Single submitter ⚠
- p.Lys298Glu Single submitter ⚠
- p.Lys417Asn Single submitter ⚠
- p.Lys418Asn Single submitter ⚠
- p.Lys730Arg Single submitter ⚠
- p.Phe218Val Single submitter ⚠
- p.Pro152Ala Single submitter
- p.Pro210Thr Single submitter ⚠
- p.Pro211Leu Single submitter ⚠
- p.Pro211Ser Single submitter ⚠
- p.Pro521Leu Single submitter ⚠
- p.Pro521Ser Single submitter ⚠
- p.Pro538Leu Single submitter ⚠
- p.Pro541Leu Single submitter ⚠
- p.Pro691Arg Single submitter ⚠
- p.Ser181Tyr Single submitter ⚠
- p.Ser344Asn Single submitter ⚠
- p.Ser456Phe Single submitter ⚠
- p.Ser556Phe Single submitter ⚠
- p.Ser57Asn Single submitter ⚠
- p.Ser599Phe Single submitter
- p.Ser621Pro Single submitter ⚠
- p.Ser640Leu Single submitter ⚠
- p.Ser650Pro Single submitter ⚠
- p.Ser68Asn Single submitter ⚠
- p.Ser745Cys Single submitter ⚠
- p.Thr166Met Single submitter ⚠
- p.Thr236Lys Single submitter ⚠
- p.Thr236Met Single submitter ⚠
- p.Thr62Ser Single submitter ⚠
- p.Thr657Ile Single submitter ⚠
- p.Trp214Arg Single submitter ⚠
- p.Trp232Leu Single submitter ⚠
- p.Trp464Arg Single submitter ⚠
- p.Tyr475Cys Single submitter ⚠
- p.Tyr571Phe Single submitter ⚠
- p.Val228Ala Single submitter
- p.Val361Ala Single submitter ⚠
- p.Val492Met Single submitter ⚠
- p.Val654Ile Single submitter ⚠