STK10 — 146 ClinVar variants

All ClinVar germline STK10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 131 flagged for review →

5 Benign · 5 Likely benign · 136 Uncertain significance

Full STK10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 131

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 100

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 31

The independent predictors disagree with each other — read with care.

All STK10 variants

Benign 5

c.2652+6G>C Single submitter
p.Ala117= Single submitter
p.Asn162= Single submitter
p.Pro394Ala Single submitter
p.Pro520Leu Single submitter

Likely benign 5

p.Asn501Ser Single submitter
p.Glu359Lys Single submitter
p.Ile297Val Single submitter
p.Ile517= Single submitter
p.Pro919= Single submitter

Uncertain significance 136

p.Ala286Val Single submitter ⚠
p.Ala420Gly Single submitter ⚠
p.Ala456Thr Single submitter ⚠
p.Ala632Val Single submitter ⚠
p.Ala833Thr Single submitter ⚠
p.Arg11His Single submitter ⚠
p.Arg11Leu Single submitter ⚠
p.Arg139Cys Single submitter ⚠
p.Arg139Leu Single submitter ⚠
p.Arg244Trp Single submitter ⚠
p.Arg268Cys Single submitter ⚠
p.Arg268His Single submitter ⚠
p.Arg27Cys Single submitter ⚠
p.Arg322Trp Single submitter ⚠
p.Arg421Gly Single submitter ⚠
p.Arg529Trp Single submitter ⚠
p.Arg597His Single submitter ⚠
p.Arg635His Single submitter ⚠
p.Arg673Gln Single submitter ⚠
p.Arg676Gln Single submitter ⚠
p.Arg696Trp Single submitter ⚠
p.Arg719Gln Single submitter ⚠
p.Arg737Gln Single submitter ⚠
p.Arg737Leu Single submitter ⚠
p.Arg739Trp Single submitter ⚠
p.Arg781Gln Single submitter ⚠
p.Arg781Trp Single submitter ⚠
p.Arg805Trp Single submitter ⚠
p.Arg817Gly Single submitter ⚠
p.Arg817His Single submitter ⚠
p.Arg837Cys Single submitter ⚠
p.Arg855Gln Single submitter ⚠
p.Arg855Trp Single submitter ⚠
p.Arg867Gln Single submitter ⚠
p.Arg8Cys Single submitter ⚠
p.Arg920Cys Single submitter ⚠
p.Arg920His Single submitter ⚠
p.Arg933Trp Single submitter ⚠
p.Asn33Lys Single submitter ⚠
p.Asn33Ser Single submitter ⚠
p.Asn402Lys Single submitter ⚠
p.Asn949Asp Single submitter ⚠
p.Asp103Asn Single submitter ⚠
p.Asp119Glu Single submitter ⚠
p.Asp253Glu Single submitter ⚠
p.Asp253His Single submitter ⚠
p.Asp31Glu Single submitter ⚠
p.Asp484Tyr Single submitter ⚠
p.Asp630Glu Single submitter ⚠
p.Cys379Gly Single submitter ⚠
p.Cys873Phe Single submitter ⚠
p.Cys947Tyr Single submitter ⚠
p.Gln622His Single submitter ⚠
p.Gln750Pro Single submitter ⚠
p.Gln857Leu Single submitter ⚠
p.Glu168Lys Single submitter ⚠
p.Glu326Gln Single submitter ⚠
p.Glu427Lys Single submitter ⚠
p.Glu550Lys Single submitter ⚠
p.Glu556Lys Single submitter ⚠
p.Glu645Asp Single submitter ⚠
p.Glu667Lys Single submitter ⚠
p.Glu854Gln Single submitter
p.Glu895Lys Single submitter ⚠
p.Glu904Gly Single submitter
p.Gly104Arg Single submitter ⚠
p.Gly194Ser Single submitter ⚠
p.Gly321Ser Single submitter ⚠
p.Gly59Ser Single submitter ⚠
p.Gly829Ser Single submitter ⚠
p.Gly830Glu Single submitter ⚠
p.His102Arg Single submitter ⚠
p.His577Gln Single submitter ⚠
p.His587Arg Single submitter ⚠
p.His631Asp Single submitter ⚠
p.Ile220Thr Single submitter ⚠
p.Ile225Val Single submitter ⚠
p.Ile233Asn Single submitter ⚠
p.Ile249Val Single submitter ⚠
p.Ile827Val Single submitter ⚠
p.Ile93Val Single submitter ⚠
p.Leu223Pro Single submitter ⚠
p.Leu30Arg Single submitter ⚠
p.Leu502Phe Single submitter ⚠
p.Leu768Val Single submitter ⚠
p.Leu899Val Single submitter ⚠
p.Lys19Arg Single submitter ⚠
p.Lys532Arg Single submitter ⚠
p.Lys54Glu Single submitter ⚠
p.Lys596Ile Single submitter ⚠
p.Lys606Arg Single submitter ⚠
p.Lys690Arg Single submitter ⚠
p.Lys803Arg Single submitter ⚠
p.Met165Ile Single submitter ⚠
p.Met209Val Single submitter ⚠
p.Met243Val Single submitter
p.Met418Thr Single submitter ⚠
p.Met627Leu Single submitter ⚠
p.Met660Val Single submitter ⚠
p.Met684Val Single submitter ⚠
p.Met746Thr Single submitter
p.Met820Leu Single submitter ⚠
p.Met937Lys Single submitter ⚠
p.Phe3Ser Single submitter ⚠
p.Phe939Ser Single submitter ⚠
p.Pro196Leu Single submitter ⚠
p.Pro292His Single submitter ⚠
p.Pro350Ser Single submitter ⚠
p.Pro365Arg Single submitter ⚠
p.Pro439Leu Single submitter ⚠
p.Pro672Ser Single submitter ⚠
p.Ser284Thr Single submitter ⚠
p.Ser296Asn Single submitter ⚠
p.Ser361Thr Single submitter ⚠
p.Ser369Gly Single submitter ⚠
p.Ser495Thr Single submitter ⚠
p.Ser514Phe Single submitter ⚠
p.Ser549Asn Single submitter ⚠
p.Ser584Asn Single submitter ⚠
p.Ser812Asn Single submitter ⚠
p.Ser905Thr Single submitter ⚠
p.Thr130Lys Single submitter ⚠
p.Thr256Met Single submitter ⚠
p.Thr336Ile Single submitter ⚠
p.Thr364Ile Single submitter ⚠
p.Thr611Ala Single submitter ⚠
p.Thr688Met Single submitter ⚠
p.Thr816Met Single submitter ⚠
p.Val118Met Single submitter
p.Val26Ile Single submitter ⚠
p.Val35Met Single submitter ⚠
p.Val39Met Single submitter ⚠
p.Val416Met Single submitter ⚠
p.Val535Leu Single submitter ⚠
p.Val633Met Single submitter ⚠
p.Val94Met Single submitter ⚠