STK16 — 48 ClinVar variants
All ClinVar germline STK16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Likely benign · 47 Uncertain significance
Full STK16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK16 p.Arg193Trp Uncertain significance Single submitter
- STK16 p.Arg199Gln Uncertain significance Single submitter
- STK16 p.Arg215Trp Uncertain significance Single submitter
- STK16 p.Arg64Gln Uncertain significance Single submitter
- STK16 p.Arg79Cys Uncertain significance Single submitter
- STK16 p.Arg79His Uncertain significance Single submitter
- STK16 p.Arg88Gln Uncertain significance Single submitter
- STK16 p.Asn171Ser Uncertain significance Single submitter
- STK16 p.Cys174Tyr Uncertain significance Single submitter
- STK16 p.Cys84Ser Uncertain significance Single submitter
- STK16 p.Gln207His Uncertain significance Single submitter
- STK16 p.Gln267Leu Uncertain significance Single submitter
- STK16 p.Gln304Glu Uncertain significance Single submitter
- STK16 p.Gly39Trp Uncertain significance Single submitter
- STK16 p.His209Arg Uncertain significance Single submitter
- STK16 p.His301Arg Uncertain significance Single submitter
- STK16 p.His41Arg Uncertain significance Single submitter
- STK16 p.Ile154Val Uncertain significance Single submitter
- STK16 p.Ile77Val Uncertain significance Single submitter
- STK16 p.Leu113Gln Uncertain significance Single submitter
- STK16 p.Leu156Pro Uncertain significance Single submitter
- STK16 p.Leu26Arg Uncertain significance Single submitter
- STK16 p.Leu48Val Uncertain significance Single submitter
- STK16 p.Leu96Pro Uncertain significance Single submitter
- STK16 p.Lys91Arg Uncertain significance Single submitter
- STK16 p.Met228Val Uncertain significance Single submitter
- STK16 p.Met237Val Uncertain significance Single submitter
- STK16 p.Ser263Leu Uncertain significance Single submitter
- STK16 p.Ser32Asn Uncertain significance Single submitter
- STK16 p.Thr105Met Uncertain significance Single submitter
- STK16 p.Thr274Asn Uncertain significance Single submitter
- STK16 p.Trp127Arg Uncertain significance Single submitter
- STK16 p.Tyr83Cys Uncertain significance Single submitter
- STK16 p.Val224Leu Uncertain significance Single submitter
- STK16 p.Val238Leu Uncertain significance Single submitter
- STK16 p.Val81Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- STK16 p.Arg10Trp Uncertain significance Single submitter
- STK16 p.Arg181Cys Uncertain significance Single submitter
- STK16 p.Gly89Val Uncertain significance Single submitter
- STK16 p.Leu120Pro Uncertain significance Single submitter
- STK16 p.Leu293His Uncertain significance Single submitter
- STK16 p.Phe45Leu Uncertain significance Single submitter
- STK16 p.Pro298Ser Uncertain significance Single submitter
- STK16 p.Ser258Gly Uncertain significance Single submitter
- STK16 p.Val275Met Uncertain significance Single submitter
All STK16 variants
Likely benign 1
- p.Arg59Gln Single submitter
Uncertain significance 47
- p.Arg10Trp Single submitter ⚠
- p.Arg181Cys Single submitter ⚠
- p.Arg193Trp Single submitter ⚠
- p.Arg199Gln Single submitter ⚠
- p.Arg19Cys Single submitter
- p.Arg215Trp Single submitter ⚠
- p.Arg64Gln Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Arg88Gln Single submitter ⚠
- p.Asn171Ser Single submitter ⚠
- p.Cys174Tyr Single submitter ⚠
- p.Cys84Ser Single submitter ⚠
- p.Gln207His Single submitter ⚠
- p.Gln267Leu Single submitter ⚠
- p.Gln304Glu Single submitter ⚠
- p.Gly39Trp Single submitter ⚠
- p.Gly89Val Single submitter ⚠
- p.His209Arg Single submitter ⚠
- p.His301Arg Single submitter ⚠
- p.His41Arg Single submitter ⚠
- p.His69Tyr Single submitter
- p.Ile154Val Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu113Gln Single submitter ⚠
- p.Leu120Pro Single submitter ⚠
- p.Leu156Pro Single submitter ⚠
- p.Leu26Arg Single submitter ⚠
- p.Leu293His Single submitter ⚠
- p.Leu48Val Single submitter ⚠
- p.Leu96Pro Single submitter ⚠
- p.Lys91Arg Single submitter ⚠
- p.Met228Val Single submitter ⚠
- p.Met237Val Single submitter ⚠
- p.Phe45Leu Single submitter ⚠
- p.Pro298Ser Single submitter ⚠
- p.Ser258Gly Single submitter ⚠
- p.Ser263Leu Single submitter ⚠
- p.Ser32Asn Single submitter ⚠
- p.Thr105Met Single submitter ⚠
- p.Thr274Asn Single submitter ⚠
- p.Trp127Arg Single submitter ⚠
- p.Tyr83Cys Single submitter ⚠
- p.Val224Leu Single submitter ⚠
- p.Val238Leu Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val81Met Single submitter ⚠