STK17A — 34 ClinVar variants

All ClinVar germline STK17A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →

1 Benign · 1 Benign/Likely benign · 1 Likely benign · 31 Uncertain significance

Full STK17A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 30

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 25

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 5

The independent predictors disagree with each other — read with care.

All STK17A variants

Benign 1

p.Leu235= Single submitter

Benign/Likely benign 1

p.Arg168Gln Multiple submitters

Likely benign 1

p.Arg180His Single submitter

Uncertain significance 31

p.Ala152Val Single submitter ⚠
p.Arg102Gln Single submitter ⚠
p.Arg168Gly Single submitter ⚠
p.Arg180Gly Single submitter ⚠
p.Asn118Ser Single submitter ⚠
p.Asn266Lys Single submitter ⚠
p.Asn266Ser Single submitter ⚠
p.Gln169His Single submitter ⚠
p.Glu401Ala Single submitter ⚠
p.Gly379Ala Single submitter ⚠
p.His125Arg Single submitter ⚠
p.Ile122Val Single submitter ⚠
p.Ile170Thr Single submitter ⚠
p.Ile205Leu Single submitter ⚠
p.Ile249Thr Single submitter ⚠
p.Ile371Thr Single submitter ⚠
p.Ile79Val Single submitter ⚠
p.Lys204Met Single submitter ⚠
p.Lys85Thr Single submitter ⚠
p.Met246Lys Single submitter ⚠
p.Met246Thr Single submitter ⚠
p.Phe272Leu Single submitter ⚠
p.Pro227Leu Single submitter ⚠
p.Pro319Ser Single submitter ⚠
p.Pro350Leu Single submitter ⚠
p.Ser281Arg Single submitter ⚠
p.Ser293Leu Single submitter ⚠
p.Ser83Cys Single submitter ⚠
p.Tyr128His Single submitter
p.Tyr254Cys Single submitter ⚠
p.Val174Ile Single submitter ⚠