STK17B — 30 ClinVar variants
All ClinVar germline STK17B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
2 Likely benign · 28 Uncertain significance
Full STK17B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK17B p.Ala61Gly Uncertain significance Single submitter
- STK17B p.Arg337Gly Uncertain significance Single submitter
- STK17B p.Arg9Gln Uncertain significance Single submitter
- STK17B p.Asn331Ser Uncertain significance Single submitter
- STK17B p.Asp323Gly Uncertain significance Single submitter
- STK17B p.Asp339Val Uncertain significance Single submitter
- STK17B p.Asp357Asn Uncertain significance Single submitter
- STK17B p.Cys330Tyr Uncertain significance Single submitter
- STK17B p.Glu105Asp Uncertain significance Single submitter
- STK17B p.Glu125Asp Uncertain significance Single submitter
- STK17B p.Glu322Asp Uncertain significance Single submitter
- STK17B p.Glu341Lys Uncertain significance Single submitter
- STK17B p.His188Arg Uncertain significance Single submitter
- STK17B p.Ile136Met Uncertain significance Single submitter
- STK17B p.Ile136Val Uncertain significance Single submitter
- STK17B p.Ile164Val Uncertain significance Single submitter
- STK17B p.Ile343Asn Uncertain significance Single submitter
- STK17B p.Ile81Val Uncertain significance Single submitter
- STK17B p.Lys340Thr Uncertain significance Single submitter
- STK17B p.Met129Ile Uncertain significance Single submitter
- STK17B p.Pro282Ser Uncertain significance Single submitter
- STK17B p.Ser260Ala Uncertain significance Single submitter
- STK17B p.Ser320Pro Uncertain significance Single submitter
- STK17B p.Thr18Ala Uncertain significance Single submitter
- STK17B p.Thr35Lys Uncertain significance Single submitter
- STK17B p.Val99Phe Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All STK17B variants
Likely benign 2
- p.Asn362Ser Single submitter
- p.His188Asn Single submitter
Uncertain significance 28
- p.Ala61Gly Single submitter ⚠
- p.Arg337Gly Single submitter ⚠
- p.Arg9Gln Single submitter ⚠
- p.Asn331Ser Single submitter ⚠
- p.Asp323Gly Single submitter ⚠
- p.Asp339Val Single submitter ⚠
- p.Asp357Asn Single submitter ⚠
- p.Cys330Tyr Single submitter ⚠
- p.Glu105Asp Single submitter ⚠
- p.Glu125Asp Single submitter ⚠
- p.Glu322Asp Single submitter ⚠
- p.Glu341Lys Single submitter ⚠
- p.His188Arg Single submitter ⚠
- p.Ile136Met Single submitter ⚠
- p.Ile136Val Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile343Asn Single submitter ⚠
- p.Ile81Val Single submitter ⚠
- p.Lys340Thr Single submitter ⚠
- p.Met129Ile Single submitter ⚠
- p.Pro171Ser Single submitter ⚠
- p.Pro282Ser Single submitter ⚠
- p.Ser104Arg Single submitter ⚠
- p.Ser260Ala Single submitter ⚠
- p.Ser320Pro Single submitter ⚠
- p.Thr18Ala Single submitter ⚠
- p.Thr35Lys Single submitter ⚠
- p.Val99Phe Single submitter ⚠