STK24 — 36 ClinVar variants
All ClinVar germline STK24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
36 Uncertain significance
Full STK24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK24 p.Ala381Val Uncertain significance Single submitter
- STK24 p.Ala60Asp Uncertain significance Single submitter
- STK24 p.Arg126Gly Uncertain significance Single submitter
- STK24 p.Arg290Ser Uncertain significance Single submitter
- STK24 p.Arg417Gln Uncertain significance Single submitter
- STK24 p.Asn149Ser Uncertain significance Single submitter
- STK24 p.Asp109Asn Uncertain significance Single submitter
- STK24 p.Asp43Glu Uncertain significance Single submitter
- STK24 p.Gln362Arg Uncertain significance Single submitter
- STK24 p.Gln362His Uncertain significance Single submitter
- STK24 p.Glu297Lys Uncertain significance Single submitter
- STK24 p.Gly156Ser Uncertain significance Single submitter
- STK24 p.Ile274Val Uncertain significance Single submitter
- STK24 p.Leu160Met Uncertain significance Single submitter
- STK24 p.Leu27Pro Uncertain significance Single submitter
- STK24 p.Leu287Pro Uncertain significance Single submitter
- STK24 p.Leu342Phe Uncertain significance Single submitter
- STK24 p.Pro334His Uncertain significance Single submitter
- STK24 p.Ser299Asn Uncertain significance Single submitter
- STK24 p.Ser429Ala Uncertain significance Single submitter
- STK24 p.Thr119Ile Uncertain significance Single submitter
- STK24 p.Thr238Met Uncertain significance Single submitter
- STK24 p.Thr428Ile Uncertain significance Single submitter
- STK24 p.Tyr89Ser Uncertain significance Single submitter
- STK24 p.Val150Phe Uncertain significance Single submitter
- STK24 p.Val227Ile Uncertain significance Single submitter
- STK24 p.Val415Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- STK24 p.Arg45Gln Uncertain significance Single submitter
- STK24 p.Asn44Ser Uncertain significance Single submitter
- STK24 p.Ile52Val Uncertain significance Single submitter
- STK24 p.Leu23Val Uncertain significance Single submitter
- STK24 p.Pro259Ala Uncertain significance Single submitter
- STK24 p.Ser198Leu Uncertain significance Single submitter
- STK24 p.Thr25Ser Uncertain significance Single submitter
- STK24 p.Tyr283Cys Uncertain significance Single submitter
All STK24 variants
Uncertain significance 36
- p.Ala381Val Single submitter ⚠
- p.Ala60Asp Single submitter ⚠
- p.Arg126Gly Single submitter ⚠
- p.Arg276His Single submitter
- p.Arg290Ser Single submitter ⚠
- p.Arg417Gln Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Asn149Ser Single submitter ⚠
- p.Asn44Ser Single submitter ⚠
- p.Asp109Asn Single submitter ⚠
- p.Asp43Glu Single submitter ⚠
- p.Gln362Arg Single submitter ⚠
- p.Gln362His Single submitter ⚠
- p.Glu297Lys Single submitter ⚠
- p.Gly156Ser Single submitter ⚠
- p.Ile274Val Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu160Met Single submitter ⚠
- p.Leu23Val Single submitter ⚠
- p.Leu27Pro Single submitter ⚠
- p.Leu287Pro Single submitter ⚠
- p.Leu342Phe Single submitter ⚠
- p.Pro259Ala Single submitter ⚠
- p.Pro334His Single submitter ⚠
- p.Ser198Leu Single submitter ⚠
- p.Ser299Asn Single submitter ⚠
- p.Ser429Ala Single submitter ⚠
- p.Thr119Ile Single submitter ⚠
- p.Thr238Met Single submitter ⚠
- p.Thr25Ser Single submitter ⚠
- p.Thr428Ile Single submitter ⚠
- p.Tyr283Cys Single submitter ⚠
- p.Tyr89Ser Single submitter ⚠
- p.Val150Phe Single submitter ⚠
- p.Val227Ile Single submitter ⚠
- p.Val415Met Single submitter ⚠