STK25 — 48 ClinVar variants
All ClinVar germline STK25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Likely benign · 47 Uncertain significance
Full STK25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK25 p.Ala261Val Uncertain significance Single submitter
- STK25 p.Ala310Val Uncertain significance Single submitter
- STK25 p.Ala8Val Uncertain significance Single submitter
- STK25 p.Arg222Cys Uncertain significance Single submitter
- STK25 p.Arg256Gln Uncertain significance Single submitter
- STK25 p.Arg258Trp Uncertain significance Single submitter
- STK25 p.Arg363Gln Uncertain significance Single submitter
- STK25 p.Arg363Trp Uncertain significance Single submitter
- STK25 p.Arg426Cys Uncertain significance Single submitter
- STK25 p.Arg426His Uncertain significance Single submitter
- STK25 p.Arg426Ser Uncertain significance Single submitter
- STK25 p.Asp129Gly Uncertain significance Single submitter
- STK25 p.Asp254Glu Uncertain significance Single submitter
- STK25 p.Gln343Pro Uncertain significance Single submitter
- STK25 p.Glu311Ala Uncertain significance Single submitter
- STK25 p.Glu410Asp Uncertain significance Single submitter
- STK25 p.Gly101Ser Uncertain significance Single submitter
- STK25 p.Gly99Cys Uncertain significance Single submitter
- STK25 p.His138Arg Uncertain significance Single submitter
- STK25 p.His3Gln Uncertain significance Single submitter
- STK25 p.Ile318Leu Uncertain significance Single submitter
- STK25 p.Ile318Ser Uncertain significance Single submitter
- STK25 p.Leu218Phe Uncertain significance Single submitter
- STK25 p.Pro255Leu Uncertain significance Single submitter
- STK25 p.Pro323Ala Uncertain significance Single submitter
- STK25 p.Pro329Ser Uncertain significance Single submitter
- STK25 p.Pro345Leu Uncertain significance Single submitter
- STK25 p.Pro348Ala Uncertain significance Single submitter
- STK25 p.Ser102Leu Uncertain significance Single submitter
- STK25 p.Ser292Leu Uncertain significance Single submitter
- STK25 p.Ser75Asn Uncertain significance Single submitter
- STK25 p.Thr166Ala Uncertain significance Single submitter
- STK25 p.Thr337Ala Uncertain significance Single submitter
- STK25 p.Thr360Met Uncertain significance Single submitter
- STK25 p.Val223Leu Uncertain significance Single submitter
- STK25 p.Val349Ile Uncertain significance Single submitter
- STK25 p.Val365Ile Uncertain significance Single submitter
- STK25 p.Val380Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- STK25 p.Arg286His Uncertain significance Single submitter
- STK25 p.Arg289Cys Uncertain significance Single submitter
- STK25 p.Arg326Trp Uncertain significance Single submitter
- STK25 p.Asp193Asn Uncertain significance Single submitter
- STK25 p.Asp52Asn Uncertain significance Single submitter
- STK25 p.Ile141Val Uncertain significance Single submitter
- STK25 p.Phe321Ser Uncertain significance Single submitter
All STK25 variants
Likely benign 1
- p.Ser341Gly Single submitter
Uncertain significance 47
- p.Ala261Val Single submitter ⚠
- p.Ala310Val Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg256Gln Single submitter ⚠
- p.Arg258Trp Single submitter ⚠
- p.Arg286Cys Single submitter
- p.Arg286His Single submitter ⚠
- p.Arg289Cys Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Arg363Gln Single submitter ⚠
- p.Arg363Trp Single submitter ⚠
- p.Arg426Cys Single submitter ⚠
- p.Arg426His Single submitter ⚠
- p.Arg426Ser Single submitter ⚠
- p.Asp129Gly Single submitter ⚠
- p.Asp193Asn Single submitter ⚠
- p.Asp254Glu Single submitter ⚠
- p.Asp52Asn Single submitter ⚠
- p.Gln343Pro Single submitter ⚠
- p.Glu311Ala Single submitter ⚠
- p.Glu410Asp Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly99Cys Single submitter ⚠
- p.His138Arg Single submitter ⚠
- p.His3Gln Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Ile318Leu Single submitter ⚠
- p.Ile318Ser Single submitter ⚠
- p.Leu218Phe Single submitter ⚠
- p.Lys210Glu Single submitter
- p.Phe321Ser Single submitter ⚠
- p.Pro255Leu Single submitter ⚠
- p.Pro323Ala Single submitter ⚠
- p.Pro329Ser Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro348Ala Single submitter ⚠
- p.Ser102Leu Single submitter ⚠
- p.Ser292Leu Single submitter ⚠
- p.Ser75Asn Single submitter ⚠
- p.Thr166Ala Single submitter ⚠
- p.Thr337Ala Single submitter ⚠
- p.Thr360Met Single submitter ⚠
- p.Val223Leu Single submitter ⚠
- p.Val349Ile Single submitter ⚠
- p.Val365Ile Single submitter ⚠
- p.Val380Met Single submitter ⚠