STK26 — 29 ClinVar variants
All ClinVar germline STK26 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Conflicting · 2 Benign · 2 Likely benign · 24 Uncertain significance
Full STK26 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK26 p.Ala113Ser Uncertain significance Single submitter
- STK26 p.Ala122Ser Uncertain significance Single submitter
- STK26 p.Arg112Gln Uncertain significance Single submitter
- STK26 p.Gln348Lys Uncertain significance Single submitter
- STK26 p.Gly31Glu Uncertain significance Single submitter
- STK26 p.Ile121Thr Uncertain significance Single submitter
- STK26 p.Lys126Arg Uncertain significance Single submitter
- STK26 p.Lys336Asn Uncertain significance Single submitter
- STK26 p.Pro5Leu Uncertain significance Single submitter
- STK26 p.Ser351Arg Uncertain significance Single submitter
- STK26 p.Ser80Leu Uncertain significance Single submitter
- STK26 p.Thr396Ala Uncertain significance Single submitter
- STK26 p.Val329Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- STK26 p.Arg45Cys Benign Multiple submitters
- STK26 p.Ala377Glu Uncertain significance Single submitter
- STK26 p.Arg29Cys Uncertain significance Single submitter
- STK26 p.Arg29His Uncertain significance Single submitter
- STK26 p.Asn44Lys Uncertain significance Single submitter
- STK26 p.Gly394Ser Uncertain significance Single submitter
- STK26 p.Gly92Arg Uncertain significance Single submitter
- STK26 p.Ile395Thr Uncertain significance Single submitter
- STK26 p.Phe361Val Uncertain significance Single submitter
- STK26 p.Ser198Leu Uncertain significance Single submitter
- STK26 p.Val240Phe Uncertain significance Single submitter
All STK26 variants
Conflicting classifications of pathogenicity 1
- p.Gln376Arg Single submitter ⚠
Benign 2
- p.Arg45Cys Multiple submitters ⚠
- p.Ser306= Single submitter
Uncertain significance 24
- p.Ala113Ser Single submitter ⚠
- p.Ala122Ser Single submitter ⚠
- p.Ala377Glu Single submitter ⚠
- p.Arg112Gln Single submitter ⚠
- p.Arg29Cys Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Asn44Lys Single submitter ⚠
- p.Gln348Lys Single submitter ⚠
- p.Gly31Glu Single submitter ⚠
- p.Gly394Ser Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.Ile121Thr Single submitter ⚠
- p.Ile395Thr Single submitter ⚠
- p.Lys126Arg Single submitter ⚠
- p.Lys336Asn Single submitter ⚠
- p.Phe361Val Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Ser198Leu Single submitter ⚠
- p.Ser351Arg Single submitter ⚠
- p.Ser80Leu Single submitter ⚠
- p.Thr396Ala Single submitter ⚠
- p.Val240Phe Single submitter ⚠
- p.Val329Ile Single submitter ⚠
- p.Val50Ile Single submitter