STK3 — 57 ClinVar variants
All ClinVar germline STK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Likely benign · 56 Uncertain significance
Full STK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK3 p.Ala124Glu Uncertain significance Single submitter
- STK3 p.Ala163Glu Uncertain significance Single submitter
- STK3 p.Ala347Ser Uncertain significance Single submitter
- STK3 p.Arg178Cys Uncertain significance Single submitter
- STK3 p.Arg301Lys Uncertain significance Single submitter
- STK3 p.Arg307Leu Uncertain significance Single submitter
- STK3 p.Arg461Gln Uncertain significance Single submitter
- STK3 p.Arg469Ile Uncertain significance Single submitter
- STK3 p.Asn413Ile Uncertain significance Single submitter
- STK3 p.Asn428Tyr Uncertain significance Single submitter
- STK3 p.Asn490Ser Uncertain significance Single submitter
- STK3 p.Asp249Asn Uncertain significance Single submitter
- STK3 p.Asp249Gly Uncertain significance Single submitter
- STK3 p.Asp317Ala Uncertain significance Single submitter
- STK3 p.Asp361Asn Uncertain significance Single submitter
- STK3 p.Asp427Glu Uncertain significance Single submitter
- STK3 p.Asp434Gly Uncertain significance Single submitter
- STK3 p.Gln412Lys Uncertain significance Single submitter
- STK3 p.Glu375Gly Uncertain significance Single submitter
- STK3 p.Glu465Gln Uncertain significance Single submitter
- STK3 p.Gly208Ala Uncertain significance Single submitter
- STK3 p.Gly217Glu Uncertain significance Single submitter
- STK3 p.His159Tyr Uncertain significance Single submitter
- STK3 p.His302Arg Uncertain significance Single submitter
- STK3 p.His302Gln Uncertain significance Single submitter
- STK3 p.Ile147Val Uncertain significance Single submitter
- STK3 p.Ile224Lys Uncertain significance Single submitter
- STK3 p.Ile286Thr Uncertain significance Single submitter
- STK3 p.Leu466Val Uncertain significance Single submitter
- STK3 p.Met214Val Uncertain significance Single submitter
- STK3 p.Met350Val Uncertain significance Single submitter
- STK3 p.Met394Val Uncertain significance Single submitter
- STK3 p.Met414Ile Uncertain significance Single submitter
- STK3 p.Met420Val Uncertain significance Single submitter
- STK3 p.Phe277Leu Uncertain significance Single submitter
- STK3 p.Phe418Cys Uncertain significance Single submitter
- STK3 p.Pro386Ser Uncertain significance Single submitter
- STK3 p.Ser106Cys Uncertain significance Single submitter
- STK3 p.Ser285Pro Uncertain significance Single submitter
- STK3 p.Ser316Leu Uncertain significance Single submitter
- STK3 p.Ser333Ile Uncertain significance Single submitter
- STK3 p.Ser392Tyr Uncertain significance Single submitter
- STK3 p.Thr336Ile Uncertain significance Single submitter
- STK3 p.Thr342Met Uncertain significance Single submitter
- STK3 p.Val388Ile Uncertain significance Single submitter
- STK3 p.Val98Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- STK3 p.Gln51His Uncertain significance Single submitter
- STK3 p.Ile212Met Uncertain significance Single submitter
- STK3 p.Lys218Gln Uncertain significance Single submitter
- STK3 p.Met140Val Uncertain significance Single submitter
- STK3 p.Met214Ile Uncertain significance Single submitter
- STK3 p.Pro391Ser Uncertain significance Single submitter
- STK3 p.Ser40Asn Likely benign Single submitter
- STK3 p.Thr378Ala Uncertain significance Single submitter
- STK3 p.Thr378Ser Uncertain significance Single submitter
- STK3 p.Val83Ile Uncertain significance Single submitter
All STK3 variants
Likely benign 1
- p.Ser40Asn Single submitter ⚠
Uncertain significance 56
- p.Ala124Glu Single submitter ⚠
- p.Ala163Glu Single submitter ⚠
- p.Ala347Ser Single submitter ⚠
- p.Arg178Cys Single submitter ⚠
- p.Arg301Lys Single submitter ⚠
- p.Arg307Leu Single submitter ⚠
- p.Arg461Gln Single submitter ⚠
- p.Arg469Ile Single submitter ⚠
- p.Asn413Ile Single submitter ⚠
- p.Asn428Tyr Single submitter ⚠
- p.Asn490Ser Single submitter ⚠
- p.Asp249Asn Single submitter ⚠
- p.Asp249Gly Single submitter ⚠
- p.Asp317Ala Single submitter ⚠
- p.Asp361Asn Single submitter ⚠
- p.Asp427Glu Single submitter ⚠
- p.Asp434Gly Single submitter ⚠
- p.Gln412Lys Single submitter ⚠
- p.Gln51His Single submitter ⚠
- p.Glu375Gly Single submitter ⚠
- p.Glu465Gln Single submitter ⚠
- p.Gly208Ala Single submitter ⚠
- p.Gly217Glu Single submitter ⚠
- p.His159Tyr Single submitter ⚠
- p.His302Arg Single submitter ⚠
- p.His302Gln Single submitter ⚠
- p.Ile147Val Single submitter ⚠
- p.Ile212Met Single submitter ⚠
- p.Ile224Lys Single submitter ⚠
- p.Ile286Thr Single submitter ⚠
- p.Ile351Thr Single submitter
- p.Leu466Val Single submitter ⚠
- p.Lys218Gln Single submitter ⚠
- p.Met140Val Single submitter ⚠
- p.Met214Ile Single submitter ⚠
- p.Met214Val Single submitter ⚠
- p.Met350Val Single submitter ⚠
- p.Met394Val Single submitter ⚠
- p.Met414Ile Single submitter ⚠
- p.Met420Val Single submitter ⚠
- p.Phe277Leu Single submitter ⚠
- p.Phe418Cys Single submitter ⚠
- p.Pro386Ser Single submitter ⚠
- p.Pro391Ser Single submitter ⚠
- p.Ser106Cys Single submitter ⚠
- p.Ser285Pro Single submitter ⚠
- p.Ser316Leu Single submitter ⚠
- p.Ser333Ile Single submitter ⚠
- p.Ser392Tyr Single submitter ⚠
- p.Thr336Ile Single submitter ⚠
- p.Thr342Met Single submitter ⚠
- p.Thr378Ala Single submitter ⚠
- p.Thr378Ser Single submitter ⚠
- p.Val388Ile Single submitter ⚠
- p.Val83Ile Single submitter ⚠
- p.Val98Ile Single submitter ⚠