STK32B — 93 ClinVar variants

All ClinVar germline STK32B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →

5 Benign · 5 Likely benign · 83 Uncertain significance

Full STK32B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 77

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 64

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All STK32B variants

Benign 5

c.563-8G>A Multiple submitters
p.Leu381= Multiple submitters
p.Pro10= Multiple submitters
p.Val100= Multiple submitters
c.563-8G>T Single submitter

Likely benign 5

p.Lys369= Single submitter
p.Pro346= Single submitter
p.Ser322= Single submitter
p.Val230Ala Single submitter
p.Thr163Ala No assertion criteria long QT syndrome

Uncertain significance 83

p.Arg70Trp Multiple submitters
p.Ala131Thr Single submitter ⚠
p.Ala168Val Single submitter ⚠
p.Ala28Thr Single submitter ⚠
p.Ala290Thr Single submitter ⚠
p.Ala290Val Single submitter ⚠
p.Arg109Cys Single submitter ⚠
p.Arg220Gln Single submitter ⚠
p.Arg220Trp Single submitter ⚠
p.Arg244Cys Single submitter ⚠
p.Arg244His Single submitter ⚠
p.Arg27Gln Single submitter ⚠
p.Arg331Gln Single submitter ⚠
p.Arg359Gln Single submitter ⚠
p.Arg367Lys Single submitter ⚠
p.Arg386Gln Single submitter ⚠
p.Arg410Cys Single submitter ⚠
p.Arg410His Single submitter ⚠
p.Arg43= Single submitter
p.Arg43Ter Single submitter
p.Arg66Gln Single submitter ⚠
p.Arg70Gln Single submitter ⚠
p.Asn19Thr Single submitter ⚠
p.Asn303Ser Single submitter ⚠
p.Asn335Ser Single submitter ⚠
p.Asn400Lys Single submitter ⚠
p.Asn402His Single submitter ⚠
p.Asn402Ser Single submitter ⚠
p.Asp197Asn Single submitter ⚠
p.Asp207Asn Single submitter ⚠
p.Asp266Asn Single submitter ⚠
p.Asp310Asn Single submitter ⚠
p.Asp384Asn Single submitter ⚠
p.Asp397Glu Single submitter ⚠
p.Cys252Ser Single submitter ⚠
p.Cys399Trp Single submitter ⚠
p.Gln113Pro Single submitter ⚠
p.Gln379Pro Single submitter ⚠
p.Gln57Arg Single submitter ⚠
p.Glu226Lys Single submitter ⚠
p.Glu268Lys Single submitter ⚠
p.Glu314Asp Single submitter ⚠
p.Gly201Arg Single submitter
p.Gly375Arg Single submitter ⚠
p.His111Arg Single submitter ⚠
p.His246Arg Single submitter ⚠
p.His5Asn Single submitter ⚠
p.Ile233Val Single submitter ⚠
p.Ile29Val Single submitter ⚠
p.Ile319Val Single submitter ⚠
p.Ile364Val Single submitter ⚠
p.Ile60Val Single submitter ⚠
p.Ile74Ser Single submitter ⚠
p.Leu296Val Single submitter ⚠
p.Leu351Pro Single submitter
p.Lys304Ile Single submitter ⚠
p.Lys330Gln Single submitter ⚠
p.Lys8Asn Single submitter ⚠
p.Met239Val Single submitter ⚠
p.Met255Thr Single submitter ⚠
p.Met286Val Single submitter ⚠
p.Met297Ile Single submitter ⚠
p.Met98Val Single submitter
p.Phe192Leu Single submitter ⚠
p.Phe69Ser Single submitter ⚠
p.Pro10Ser Single submitter ⚠
p.Pro267Ser Single submitter ⚠
p.Pro324Ser Single submitter ⚠
p.Pro346Leu Single submitter ⚠
p.Ser210Ala Single submitter ⚠
p.Ser272Pro Single submitter ⚠
p.Ser337Tyr Single submitter ⚠
p.Ser393Asn Single submitter ⚠
p.Thr119Ala Single submitter ⚠
p.Thr169Met Single submitter ⚠
p.Thr250Lys Single submitter ⚠
p.Thr250Met Single submitter ⚠
p.Thr409Ile Single submitter ⚠
p.Trp251Arg Single submitter ⚠
p.Tyr110His Single submitter ⚠
p.Val230Ile Single submitter ⚠
p.Val242Met Single submitter ⚠
p.Val271Met Single submitter ⚠