STK33 — 90 ClinVar variants

All ClinVar germline STK33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →

1 Pathogenic · 1 Conflicting · 10 Likely benign · 78 Uncertain significance

Full STK33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 74

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

STK33 p.Gln429Pro Conflicting Single submitter

Predictors lean, ClinVar uncertain 72

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 1

The independent predictors disagree with each other — read with care.

STK33 p.Arg120Gly Uncertain significance Single submitter

All STK33 variants

Pathogenic 1

p.Thr412fs No assertion criteria spermatogenic failure 93

Conflicting classifications of pathogenicity 1

p.Gln429Pro Single submitter ⚠

Likely benign 10

p.Arg318Cys Single submitter
p.Gln90= Single submitter
p.Gly432Arg Single submitter
p.Ile251Thr Single submitter
p.Ile350Val Single submitter
p.Lys12Glu Single submitter
p.Met466Thr Single submitter
p.Ser274Gly Single submitter
p.Val312Ile Single submitter
p.Val408Asp Single submitter

Uncertain significance 78

p.Ala223Ser Single submitter ⚠
p.Ala223Thr Single submitter ⚠
p.Ala269Val Single submitter ⚠
p.Ala372Thr Single submitter
p.Ala506Thr Single submitter ⚠
p.Arg120Gly Single submitter ⚠
p.Arg206Lys Single submitter ⚠
p.Arg318His Single submitter ⚠
p.Arg369Gly Single submitter ⚠
p.Arg509Thr Single submitter ⚠
p.Arg93Gln Single submitter ⚠
p.Arg93Trp Single submitter ⚠
p.Asn378His Single submitter ⚠
p.Asn393Ser Single submitter ⚠
p.Asn404Ser Single submitter ⚠
p.Asn463Ser Single submitter ⚠
p.Asn64Asp Single submitter ⚠
p.Asp15Ala Single submitter ⚠
p.Asp197Val Single submitter ⚠
p.Asp299Glu Single submitter ⚠
p.Asp352Ala Single submitter ⚠
p.Asp352Asn Single submitter ⚠
p.Asp352Glu Single submitter ⚠
p.Asp352Val Single submitter ⚠
p.Asp436His Single submitter ⚠
p.Asp442His Single submitter ⚠
p.Asp462Gly Single submitter ⚠
p.Cys26Phe Single submitter ⚠
p.Cys353Tyr Single submitter ⚠
p.Gln180His Single submitter ⚠
p.Glu107Gly Single submitter ⚠
p.Glu113Lys Single submitter ⚠
p.Glu139Ala Single submitter ⚠
p.Glu139Lys Single submitter ⚠
p.Glu199Gln Single submitter ⚠
p.Glu410Gly Single submitter ⚠
p.Glu58Gly Single submitter ⚠
p.Ile112Phe Single submitter ⚠
p.Ile112Val Single submitter ⚠
p.Ile115Val Single submitter ⚠
p.Ile144Met Single submitter ⚠
p.Ile176Val Single submitter ⚠
p.Ile295Val Single submitter ⚠
p.Ile48Val Single submitter ⚠
p.Ile65Met Single submitter ⚠
p.Leu159Ile Single submitter ⚠
p.Leu268Phe Single submitter
p.Lys201Arg Single submitter ⚠
p.Lys201Gln Single submitter ⚠
p.Lys240Gln Single submitter ⚠
p.Lys262Gln Single submitter ⚠
p.Met290Val Single submitter
p.Met466Ile Single submitter ⚠
p.Phe118Val Single submitter ⚠
p.Phe471Val Single submitter ⚠
p.Pro321Leu Single submitter ⚠
p.Pro366Ala Single submitter
p.Pro419Arg Single submitter ⚠
p.Pro419Leu Single submitter ⚠
p.Ser10Cys Single submitter ⚠
p.Ser126Gly Single submitter ⚠
p.Ser248Gly Single submitter ⚠
p.Ser274Asn Single submitter ⚠
p.Ser349Phe Single submitter ⚠
p.Ser407Gly Single submitter ⚠
p.Ser470Gly Single submitter ⚠
p.Ser474Ile Single submitter ⚠
p.Ser504Pro Single submitter ⚠
p.Ser50Gly Single submitter ⚠
p.Thr184Met Single submitter
p.Thr413Ile Single submitter ⚠
p.Thr440Ile Single submitter ⚠
p.Thr488Asn Single submitter ⚠
p.Thr498Ile Single submitter ⚠
p.Trp431Cys Single submitter ⚠
p.Tyr300Cys Single submitter ⚠
p.Val311Ile Single submitter ⚠
p.Val364Ile Single submitter ⚠