STK35 — 63 ClinVar variants
All ClinVar germline STK35 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
3 Likely benign · 60 Uncertain significance
Full STK35 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK35 p.Ala120Val Uncertain significance Single submitter
- STK35 p.Ala132Thr Uncertain significance Single submitter
- STK35 p.Ala177Val Uncertain significance Single submitter
- STK35 p.Ala178Val Uncertain significance Single submitter
- STK35 p.Ala17Pro Uncertain significance Single submitter
- STK35 p.Ala180Val Uncertain significance Single submitter
- STK35 p.Ala184Thr Uncertain significance Single submitter
- STK35 p.Ala246Ser Uncertain significance Single submitter
- STK35 p.Arg108His Uncertain significance Single submitter
- STK35 p.Arg121Pro Uncertain significance Single submitter
- STK35 p.Arg165Ser Uncertain significance Single submitter
- STK35 p.Arg188Gly Uncertain significance Single submitter
- STK35 p.Arg190Leu Uncertain significance Single submitter
- STK35 p.Arg21Trp Uncertain significance Single submitter
- STK35 p.Arg223Gly Uncertain significance Single submitter
- STK35 p.Arg494His Uncertain significance Single submitter
- STK35 p.Asn402His Uncertain significance Single submitter
- STK35 p.Asp360Tyr Uncertain significance Single submitter
- STK35 p.Gln146Glu Uncertain significance Single submitter
- STK35 p.Gln504Arg Uncertain significance Single submitter
- STK35 p.Gly119Ala Uncertain significance Single submitter
- STK35 p.Gly119Arg Uncertain significance Single submitter
- STK35 p.Gly137Arg Uncertain significance Single submitter
- STK35 p.Gly15Asp Uncertain significance Single submitter
- STK35 p.Gly182Asp Uncertain significance Single submitter
- STK35 p.Gly222Arg Uncertain significance Single submitter
- STK35 p.Gly25Arg Uncertain significance Single submitter
- STK35 p.Gly417Ser Uncertain significance Single submitter
- STK35 p.His31Asp Uncertain significance Single submitter
- STK35 p.Ile101Met Uncertain significance Single submitter
- STK35 p.Leu164Gln Uncertain significance Single submitter
- STK35 p.Lys138Gln Uncertain significance Single submitter
- STK35 p.Pro104Ser Uncertain significance Single submitter
- STK35 p.Pro106Leu Uncertain significance Single submitter
- STK35 p.Pro128Leu Uncertain significance Single submitter
- STK35 p.Pro129Arg Uncertain significance Single submitter
- STK35 p.Pro129Thr Uncertain significance Single submitter
- STK35 p.Pro131Leu Uncertain significance Single submitter
- STK35 p.Pro148Leu Uncertain significance Single submitter
- STK35 p.Pro148Ser Uncertain significance Single submitter
- STK35 p.Pro155Leu Uncertain significance Single submitter
- STK35 p.Pro160Leu Uncertain significance Single submitter
- STK35 p.Pro166Leu Uncertain significance Single submitter
- STK35 p.Pro334Ser Uncertain significance Single submitter
- STK35 p.Ser197Cys Uncertain significance Single submitter
- STK35 p.Ser34Arg Uncertain significance Single submitter
- STK35 p.Ser34Asn Uncertain significance Single submitter
- STK35 p.Thr145Lys Uncertain significance Single submitter
- STK35 p.Thr162Met Uncertain significance Single submitter
- STK35 p.Thr336Ile Uncertain significance Single submitter
- STK35 p.Thr374Ile Uncertain significance Single submitter
- STK35 p.Val230Ile Uncertain significance Single submitter
- STK35 p.Val32Met Uncertain significance Single submitter
- STK35 p.Val530Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- STK35 p.Arg300Gly Uncertain significance Single submitter
- STK35 p.Asn324Ser Uncertain significance Single submitter
- STK35 p.Gly273Arg Uncertain significance Single submitter
- STK35 p.Gly390Trp Uncertain significance Single submitter
- STK35 p.Leu274Ser Uncertain significance Single submitter
- STK35 p.Ser279Arg Uncertain significance Single submitter
All STK35 variants
Likely benign 3
- p.Arg171Gln Single submitter
- p.Phe185Tyr Single submitter
- p.Thr162Ala Single submitter
Uncertain significance 60
- p.Ala120Val Single submitter ⚠
- p.Ala132Thr Single submitter ⚠
- p.Ala177Val Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala17Pro Single submitter ⚠
- p.Ala180Val Single submitter ⚠
- p.Ala184Thr Single submitter ⚠
- p.Ala246Ser Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg121Pro Single submitter ⚠
- p.Arg165Ser Single submitter ⚠
- p.Arg188Gly Single submitter ⚠
- p.Arg190Leu Single submitter ⚠
- p.Arg21Trp Single submitter ⚠
- p.Arg223Gly Single submitter ⚠
- p.Arg300Gly Single submitter ⚠
- p.Arg494His Single submitter ⚠
- p.Asn324Ser Single submitter ⚠
- p.Asn402His Single submitter ⚠
- p.Asp360Tyr Single submitter ⚠
- p.Gln146Glu Single submitter ⚠
- p.Gln504Arg Single submitter ⚠
- p.Gly119Ala Single submitter ⚠
- p.Gly119Arg Single submitter ⚠
- p.Gly137Arg Single submitter ⚠
- p.Gly15Asp Single submitter ⚠
- p.Gly182Asp Single submitter ⚠
- p.Gly222Arg Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly273Arg Single submitter ⚠
- p.Gly390Trp Single submitter ⚠
- p.Gly417Ser Single submitter ⚠
- p.His31Asp Single submitter ⚠
- p.Ile101Met Single submitter ⚠
- p.Leu164Gln Single submitter ⚠
- p.Leu274Ser Single submitter ⚠
- p.Lys138Gln Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro106Leu Single submitter ⚠
- p.Pro128Leu Single submitter ⚠
- p.Pro129Arg Single submitter ⚠
- p.Pro129Thr Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro148Leu Single submitter ⚠
- p.Pro148Ser Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro166Leu Single submitter ⚠
- p.Pro334Ser Single submitter ⚠
- p.Ser197Cys Single submitter ⚠
- p.Ser279Arg Single submitter ⚠
- p.Ser34Arg Single submitter ⚠
- p.Ser34Asn Single submitter ⚠
- p.Thr145Lys Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr336Ile Single submitter ⚠
- p.Thr374Ile Single submitter ⚠
- p.Val230Ile Single submitter ⚠
- p.Val32Met Single submitter ⚠
- p.Val530Ile Single submitter ⚠