STK38 — 44 ClinVar variants
All ClinVar germline STK38 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Benign · 42 Uncertain significance
Full STK38 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK38 p.Ala123Thr Uncertain significance Single submitter
- STK38 p.Ala136Val Uncertain significance Single submitter
- STK38 p.Ala290Ser Uncertain significance Single submitter
- STK38 p.Ala353Pro Uncertain significance Single submitter
- STK38 p.Arg104Trp Uncertain significance Single submitter
- STK38 p.Arg121Cys Uncertain significance Single submitter
- STK38 p.Arg276Cys Uncertain significance Single submitter
- STK38 p.Asn300Tyr Uncertain significance Single submitter
- STK38 p.Asn435Ser Uncertain significance Single submitter
- STK38 p.Asp59Val Uncertain significance Single submitter
- STK38 p.Cys9Ser Uncertain significance Single submitter
- STK38 p.His210Gln Uncertain significance Single submitter
- STK38 p.Ile193Val Uncertain significance Single submitter
- STK38 p.Ile213Val Uncertain significance Single submitter
- STK38 p.Ile399Val Uncertain significance Single submitter
- STK38 p.Leu177Phe Uncertain significance Single submitter
- STK38 p.Met117Val Uncertain significance Single submitter
- STK38 p.Met166Val Uncertain significance Single submitter
- STK38 p.Met335Thr Uncertain significance Single submitter
- STK38 p.Met3Arg Uncertain significance Single submitter
- STK38 p.Pro344Leu Uncertain significance Single submitter
- STK38 p.Pro345Ala Uncertain significance Single submitter
- STK38 p.Ser146Asn Uncertain significance Single submitter
- STK38 p.Ser202Cys Uncertain significance Single submitter
- STK38 p.Ser255Cys Uncertain significance Single submitter
- STK38 p.Thr422Arg Uncertain significance Single submitter
- STK38 p.Tyr154Cys Uncertain significance Single submitter
- STK38 p.Tyr163Cys Uncertain significance Single submitter
- STK38 p.Tyr460Cys Uncertain significance Single submitter
- STK38 p.Val106Leu Uncertain significance Single submitter
- STK38 p.Val347Ile Uncertain significance Single submitter
- STK38 p.Val385Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All STK38 variants
Uncertain significance 42
- p.Ala123Thr Single submitter ⚠
- p.Ala136Val Single submitter ⚠
- p.Ala290Ser Single submitter ⚠
- p.Ala353Pro Single submitter ⚠
- p.Ala456Glu Single submitter
- p.Arg104Trp Single submitter ⚠
- p.Arg121Cys Single submitter ⚠
- p.Arg276Cys Single submitter ⚠
- p.Asn248Tyr Single submitter
- p.Asn300Tyr Single submitter ⚠
- p.Asn435Ser Single submitter ⚠
- p.Asp59Val Single submitter ⚠
- p.Cys9Ser Single submitter ⚠
- p.His210fs Single submitter bladder exstrophy-epispadias-cloacal exstrophy complex
- p.His210Gln Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile213Val Single submitter ⚠
- p.Ile289Val Single submitter ⚠
- p.Ile399Val Single submitter ⚠
- p.Leu177Phe Single submitter ⚠
- p.Leu206Val Single submitter
- p.Met117Val Single submitter ⚠
- p.Met166Val Single submitter ⚠
- p.Met335Thr Single submitter ⚠
- p.Met3Arg Single submitter ⚠
- p.Phe280Leu Single submitter ⚠
- p.Pro344Leu Single submitter ⚠
- p.Pro345Ala Single submitter ⚠
- p.Ser146Asn Single submitter ⚠
- p.Ser202Cys Single submitter ⚠
- p.Ser255Cys Single submitter ⚠
- p.Thr422Arg Single submitter ⚠
- p.Trp148Cys Single submitter ⚠
- p.Tyr154Cys Single submitter ⚠
- p.Tyr163Cys Single submitter ⚠
- p.Tyr460Cys Single submitter ⚠
- p.Val106Leu Single submitter ⚠
- p.Val293Met Single submitter ⚠
- p.Val347Ile Single submitter ⚠
- p.Val385Ile Single submitter ⚠
- p.Val385Leu Single submitter ⚠
- p.Glu75fs No assertion criteria dilated cardiomyopathy