STK38L — 38 ClinVar variants
All ClinVar germline STK38L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Benign · 3 Likely benign · 33 Uncertain significance
Full STK38L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK38L p.Ala52Val Uncertain significance Single submitter
- STK38L p.Arg212Gln Uncertain significance Single submitter
- STK38L p.Arg72His Uncertain significance Single submitter
- STK38L p.Arg79Trp Uncertain significance Single submitter
- STK38L p.Asn15Ser Uncertain significance Single submitter
- STK38L p.Asn249Ser Uncertain significance Single submitter
- STK38L p.Asn262Ser Uncertain significance Single submitter
- STK38L p.Asp159Glu Uncertain significance Single submitter
- STK38L p.Gly370Ala Uncertain significance Single submitter
- STK38L p.Gly379Asp Uncertain significance Single submitter
- STK38L p.Gly379Cys Uncertain significance Single submitter
- STK38L p.His226Asn Uncertain significance Single submitter
- STK38L p.His252Arg Uncertain significance Single submitter
- STK38L p.Ile391Val Uncertain significance Single submitter
- STK38L p.Ile400Met Uncertain significance Single submitter
- STK38L p.Lys339Arg Uncertain significance Single submitter
- STK38L p.Lys73Arg Uncertain significance Single submitter
- STK38L p.Met13Val Uncertain significance Single submitter
- STK38L p.Met3Val Uncertain significance Single submitter
- STK38L p.Met459Val Uncertain significance Single submitter
- STK38L p.Phe383Ser Uncertain significance Single submitter
- STK38L p.Thr10Ala Uncertain significance Single submitter
- STK38L p.Thr10Ile Uncertain significance Single submitter
- STK38L p.Thr426Asn Uncertain significance Single submitter
- STK38L p.Tyr458Asp Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- STK38L p.Glu62Lys Uncertain significance Single submitter
- STK38L p.Glu76Gln Uncertain significance Single submitter
- STK38L p.Met313Ile Uncertain significance Single submitter
- STK38L p.Phe31Leu Uncertain significance Single submitter
- STK38L p.Thr197Ile Uncertain significance Single submitter
- STK38L p.Trp149Cys Uncertain significance Single submitter
All STK38L variants
Likely benign 3
- p.Gln451= Single submitter
- c.187-6dup No assertion criteria STK38L-related disorder
- c.673-3del No assertion criteria STK38L-related disorder
Uncertain significance 33
- c.309+1G>C Single submitter
- p.Ala52Val Single submitter ⚠
- p.Arg212Gln Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Arg79Trp Single submitter ⚠
- p.Asn15Ser Single submitter ⚠
- p.Asn249Ser Single submitter ⚠
- p.Asn262Ser Single submitter ⚠
- p.Asp159Glu Single submitter ⚠
- p.Glu62Lys Single submitter ⚠
- p.Glu76Gln Single submitter ⚠
- p.Gly370Ala Single submitter ⚠
- p.Gly379Asp Single submitter ⚠
- p.Gly379Cys Single submitter ⚠
- p.His226Asn Single submitter ⚠
- p.His252Arg Single submitter ⚠
- p.Ile391Val Single submitter ⚠
- p.Ile400Met Single submitter ⚠
- p.Lys339Arg Single submitter ⚠
- p.Lys73Arg Single submitter ⚠
- p.Met13Val Single submitter ⚠
- p.Met313Ile Single submitter ⚠
- p.Met3Val Single submitter ⚠
- p.Met459Val Single submitter ⚠
- p.Phe31Leu Single submitter ⚠
- p.Phe383Ser Single submitter ⚠
- p.Thr10Ala Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr197Ile Single submitter ⚠
- p.Thr327fs Single submitter
- p.Thr426Asn Single submitter ⚠
- p.Trp149Cys Single submitter ⚠
- p.Tyr458Asp Single submitter ⚠