STK39 — 56 ClinVar variants
All ClinVar germline STK39 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Benign · 3 Likely benign · 52 Uncertain significance
Full STK39 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STK39 p.Ala167Thr Uncertain significance Single submitter
- STK39 p.Ala23Val Uncertain significance Single submitter
- STK39 p.Ala254Val Uncertain significance Single submitter
- STK39 p.Ala27Ser Uncertain significance Single submitter
- STK39 p.Ala29Val Uncertain significance Single submitter
- STK39 p.Ala2Glu Uncertain significance Single submitter
- STK39 p.Ala50Pro Uncertain significance Single submitter
- STK39 p.Ala522Ser Uncertain significance Single submitter
- STK39 p.Ala53Val Uncertain significance Single submitter
- STK39 p.Arg156Gln Uncertain significance Single submitter
- STK39 p.Arg365Gly Uncertain significance Single submitter
- STK39 p.Arg445Gly Uncertain significance Single submitter
- STK39 p.Arg93Trp Uncertain significance Single submitter
- STK39 p.Asn439Asp Uncertain significance Single submitter
- STK39 p.Asn439Thr Uncertain significance Single submitter
- STK39 p.Asp443Tyr Uncertain significance Single submitter
- STK39 p.Cys525Ser Uncertain significance Single submitter
- STK39 p.Cys525Tyr Uncertain significance Single submitter
- STK39 p.Gln12His Uncertain significance Single submitter
- STK39 p.Gln427Pro Uncertain significance Single submitter
- STK39 p.Glu411Gly Uncertain significance Single submitter
- STK39 p.Glu442Asp Uncertain significance Single submitter
- STK39 p.Glu64Lys Uncertain significance Single submitter
- STK39 p.Gly55Cys Uncertain significance Single submitter
- STK39 p.Gly55Ser Uncertain significance Single submitter
- STK39 p.Gly6Arg Uncertain significance Single submitter
- STK39 p.Ile153Val Uncertain significance Single submitter
- STK39 p.Ile172Val Uncertain significance Single submitter
- STK39 p.Ile357Val Uncertain significance Single submitter
- STK39 p.Lys312Ile Uncertain significance Single submitter
- STK39 p.Phe128Cys Uncertain significance Single submitter
- STK39 p.Pro28Ala Uncertain significance Single submitter
- STK39 p.Pro4Ser Uncertain significance Single submitter
- STK39 p.Ser449Pro Uncertain significance Single submitter
- STK39 p.Ser528Leu Uncertain significance Single submitter
- STK39 p.Ser5Gly Uncertain significance Single submitter
- STK39 p.Thr21Arg Uncertain significance Single submitter
- STK39 p.Val122Leu Uncertain significance Single submitter
- STK39 p.Val54Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- STK39 p.Asp61Gly Uncertain significance Single submitter
- STK39 p.Gln100Arg Uncertain significance Single submitter
- STK39 p.Glu344Gly Uncertain significance Single submitter
- STK39 p.His373Gln Uncertain significance Single submitter
- STK39 p.Lys376Glu Uncertain significance Single submitter
- STK39 p.Ser114Asn Uncertain significance Single submitter
- STK39 p.Ser371Gly Uncertain significance Single submitter
- STK39 p.Ser448Tyr Uncertain significance Single submitter
- STK39 p.Ser449Phe Uncertain significance Single submitter
- STK39 p.Thr219Ala Uncertain significance Single submitter
All STK39 variants
Benign 1
- p.43PA[5] Single submitter
Likely benign 3
- p.Ala29= Multiple submitters
- p.Asn439Ser Single submitter
- p.Ser448Ala Single submitter
Uncertain significance 52
- p.Ala167Thr Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala254Val Single submitter ⚠
- p.Ala27Ser Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Ala2Glu Single submitter ⚠
- p.Ala50Pro Single submitter ⚠
- p.Ala522Ser Single submitter ⚠
- p.Ala53Val Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg365Gly Single submitter ⚠
- p.Arg445Gly Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asn439Asp Single submitter ⚠
- p.Asn439Thr Single submitter ⚠
- p.Asp443Tyr Single submitter ⚠
- p.Asp61Gly Single submitter ⚠
- p.Cys525Ser Single submitter ⚠
- p.Cys525Tyr Single submitter ⚠
- p.Gln100Arg Single submitter ⚠
- p.Gln12His Single submitter ⚠
- p.Gln427Pro Single submitter ⚠
- p.Glu344Gly Single submitter ⚠
- p.Glu411Gly Single submitter ⚠
- p.Glu442Asp Single submitter ⚠
- p.Glu64Lys Single submitter ⚠
- p.Gly55Cys Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.His373Arg Single submitter
- p.His373Gln Single submitter ⚠
- p.Ile153Val Single submitter ⚠
- p.Ile172Val Single submitter ⚠
- p.Ile357Val Single submitter ⚠
- p.Leu313Ter Single submitter
- p.Lys312Ile Single submitter ⚠
- p.Lys376Glu Single submitter ⚠
- p.Phe128Cys Single submitter ⚠
- p.Pro19fs Single submitter
- p.Pro28Ala Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Ser114Asn Single submitter ⚠
- p.Ser371Gly Single submitter ⚠
- p.Ser448Tyr Single submitter ⚠
- p.Ser449Phe Single submitter ⚠
- p.Ser449Pro Single submitter ⚠
- p.Ser528Leu Single submitter ⚠
- p.Ser5Gly Single submitter ⚠
- p.Thr219Ala Single submitter ⚠
- p.Thr21Arg Single submitter ⚠
- p.Val122Leu Single submitter ⚠
- p.Val54Ile Single submitter ⚠