STOM — 25 ClinVar variants
All ClinVar germline STOM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
25 Uncertain significance
Full STOM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STOM p.Thr266Ala Uncertain significance Multiple submitters
- STOM p.Val126Ile Uncertain significance Multiple submitters
- STOM p.Ala213Val Uncertain significance Single submitter
- STOM p.Ala36Val Uncertain significance Single submitter
- STOM p.Asn159Asp Uncertain significance Single submitter
- STOM p.Asp95Asn Uncertain significance Single submitter
- STOM p.Glu216Lys Uncertain significance Single submitter
- STOM p.His172Leu Uncertain significance Single submitter
- STOM p.Ile44Arg Uncertain significance Single submitter
- STOM p.Lys111Glu Uncertain significance Single submitter
- STOM p.Met239Thr Uncertain significance Single submitter
- STOM p.Met52Thr Uncertain significance Single submitter
- STOM p.Phe101Leu Uncertain significance Single submitter
- STOM p.Pro23Leu Uncertain significance Single submitter
- STOM p.Pro272Thr Uncertain significance Single submitter
- STOM p.Thr115Ser Uncertain significance Single submitter
- STOM p.Thr130Ile Uncertain significance Single submitter
- STOM p.Tyr252Asn Uncertain significance Single submitter
- STOM p.Val118Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All STOM variants
Uncertain significance 25
- p.Gly278Glu Multiple submitters ⚠
- p.Thr266Ala Multiple submitters ⚠
- p.Val126Ile Multiple submitters ⚠
- p.Ala139Thr Single submitter ⚠
- p.Ala213Val Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Ala63Gly Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Asn159Asp Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Glu216Lys Single submitter ⚠
- p.Glu243Lys Single submitter
- p.His172Leu Single submitter ⚠
- p.Ile44Arg Single submitter ⚠
- p.Lys111Glu Single submitter ⚠
- p.Met239Thr Single submitter ⚠
- p.Met52Thr Single submitter ⚠
- p.Phe101Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro272Thr Single submitter ⚠
- p.Ser24Cys Single submitter ⚠
- p.Thr115Ser Single submitter ⚠
- p.Thr130Ile Single submitter ⚠
- p.Tyr252Asn Single submitter ⚠
- p.Val118Met Single submitter ⚠