STOML2 — 26 ClinVar variants
All ClinVar germline STOML2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
26 Uncertain significance
Full STOML2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STOML2 p.Arg174Cys Uncertain significance Multiple submitters
- STOML2 p.Ala24Pro Uncertain significance Single submitter
- STOML2 p.Arg198Trp Uncertain significance Single submitter
- STOML2 p.Arg201Trp Uncertain significance Single submitter
- STOML2 p.Arg23His Uncertain significance Single submitter
- STOML2 p.Arg259Gln Uncertain significance Single submitter
- STOML2 p.Arg27His Uncertain significance Single submitter
- STOML2 p.Arg34Gly Uncertain significance Single submitter
- STOML2 p.Gln163His Uncertain significance Single submitter
- STOML2 p.Gln239His Uncertain significance Single submitter
- STOML2 p.Glu188Lys Uncertain significance Single submitter
- STOML2 p.Glu81Asp Uncertain significance Single submitter
- STOML2 p.Leu107Pro Uncertain significance Single submitter
- STOML2 p.Met355Thr Uncertain significance Single submitter
- STOML2 p.Ser142Phe Uncertain significance Single submitter
- STOML2 p.Ser29Thr Uncertain significance Single submitter
- STOML2 p.Ser335Arg Uncertain significance Single submitter
- STOML2 p.Val247Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- STOML2 p.Arg199Gln Uncertain significance Single submitter
- STOML2 p.Asp102Asn Uncertain significance Single submitter
- STOML2 p.Asp121Asn Uncertain significance Single submitter
- STOML2 p.Asp304Asn Uncertain significance Single submitter
- STOML2 p.Glu188Gln Uncertain significance Single submitter
- STOML2 p.Glu243Lys Uncertain significance Single submitter
- STOML2 p.Lys140Arg Uncertain significance Single submitter
All STOML2 variants
Uncertain significance 26
- p.Arg174Cys Multiple submitters ⚠
- p.Ala24Pro Single submitter ⚠
- p.Arg198Trp Single submitter ⚠
- p.Arg199Gln Single submitter ⚠
- p.Arg201Trp Single submitter ⚠
- p.Arg23His Single submitter ⚠
- p.Arg259Gln Single submitter ⚠
- p.Arg27His Single submitter ⚠
- p.Arg34Gly Single submitter ⚠
- p.Asp102Asn Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp304Asn Single submitter ⚠
- p.Gln163His Single submitter ⚠
- p.Gln239His Single submitter ⚠
- p.Glu188Gln Single submitter ⚠
- p.Glu188Lys Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu81Asp Single submitter ⚠
- p.Leu107Pro Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Met355Thr Single submitter ⚠
- p.Ser142Phe Single submitter ⚠
- p.Ser29Thr Single submitter ⚠
- p.Ser335Arg Single submitter ⚠
- p.Ser78Asn Single submitter
- p.Val247Ile Single submitter ⚠