STRN4 — 113 ClinVar variants
All ClinVar germline STRN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
3 Benign · 6 Likely benign · 104 Uncertain significance
Full STRN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 80
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STRN4 p.Ala11Val Uncertain significance Single submitter
- STRN4 p.Ala124Val Uncertain significance Single submitter
- STRN4 p.Ala14Gly Uncertain significance Single submitter
- STRN4 p.Ala14Val Uncertain significance Single submitter
- STRN4 p.Ala24Thr Uncertain significance Single submitter
- STRN4 p.Ala473Thr Uncertain significance Single submitter
- STRN4 p.Ala473Val Uncertain significance Single submitter
- STRN4 p.Ala478Val Uncertain significance Single submitter
- STRN4 p.Ala496Thr Uncertain significance Single submitter
- STRN4 p.Ala692Thr Uncertain significance Single submitter
- STRN4 p.Ala745Thr Uncertain significance Single submitter
- STRN4 p.Ala84Thr Uncertain significance Single submitter
- STRN4 p.Ala84Val Uncertain significance Single submitter
- STRN4 p.Ala9Glu Uncertain significance Single submitter
- STRN4 p.Arg175Gln Uncertain significance Single submitter
- STRN4 p.Arg18Cys Uncertain significance Single submitter
- STRN4 p.Arg205Cys Uncertain significance Single submitter
- STRN4 p.Arg205Gly Uncertain significance Single submitter
- STRN4 p.Arg335Trp Uncertain significance Single submitter
- STRN4 p.Arg336Gln Uncertain significance Single submitter
- STRN4 p.Arg349Cys Uncertain significance Single submitter
- STRN4 p.Arg349His Uncertain significance Single submitter
- STRN4 p.Arg381Gln Uncertain significance Single submitter
- STRN4 p.Arg381Trp Uncertain significance Single submitter
- STRN4 p.Arg558Cys Uncertain significance Single submitter
- STRN4 p.Arg632Gln Uncertain significance Single submitter
- STRN4 p.Arg85Cys Uncertain significance Single submitter
- STRN4 p.Asn156Ser Uncertain significance Single submitter
- STRN4 p.Asn476Ser Uncertain significance Single submitter
- STRN4 p.Asn476Tyr Uncertain significance Single submitter
- STRN4 p.Asp362Glu Uncertain significance Single submitter
- STRN4 p.Asp412Asn Uncertain significance Single submitter
- STRN4 p.Asp522Glu Uncertain significance Single submitter
- STRN4 p.Gln143His Uncertain significance Single submitter
- STRN4 p.Gln639His Uncertain significance Single submitter
- STRN4 p.Gln642His Uncertain significance Single submitter
- STRN4 p.Gln715Arg Uncertain significance Single submitter
- STRN4 p.Glu145Gln Uncertain significance Single submitter
- STRN4 p.Glu217Asp Uncertain significance Single submitter
- STRN4 p.Glu233Lys Uncertain significance Single submitter
- STRN4 p.Glu302Lys Uncertain significance Single submitter
- STRN4 p.Glu345Lys Uncertain significance Single submitter
- STRN4 p.Glu602Lys Uncertain significance Single submitter
- STRN4 p.Glu61Ala Uncertain significance Single submitter
- STRN4 p.Gly27Ser Uncertain significance Single submitter
- STRN4 p.Gly633Asp Uncertain significance Single submitter
- STRN4 p.Ile392Val Uncertain significance Single submitter
- STRN4 p.Ile606Val Uncertain significance Single submitter
- STRN4 p.Leu360Val Uncertain significance Single submitter
- STRN4 p.Leu627Phe Uncertain significance Single submitter
- STRN4 p.Lys431Arg Uncertain significance Single submitter
- STRN4 p.Met2Leu Uncertain significance Single submitter
- STRN4 p.Met499Val Uncertain significance Single submitter
- STRN4 p.Met525Thr Uncertain significance Single submitter
- STRN4 p.Met525Val Uncertain significance Single submitter
- STRN4 p.Met620Thr Uncertain significance Single submitter
- STRN4 p.Pro19Gln Uncertain significance Single submitter
- STRN4 p.Pro301Ser Uncertain significance Single submitter
- STRN4 p.Pro367Ser Uncertain significance Single submitter
- STRN4 p.Pro373Leu Uncertain significance Single submitter
- STRN4 p.Pro54Leu Uncertain significance Single submitter
- STRN4 p.Ser161Leu Uncertain significance Single submitter
- STRN4 p.Ser35Pro Uncertain significance Single submitter
- STRN4 p.Ser451Leu Uncertain significance Single submitter
- STRN4 p.Ser53Arg Uncertain significance Single submitter
- STRN4 p.Ser53Ile Uncertain significance Single submitter
- STRN4 p.Ser645Thr Uncertain significance Single submitter
- STRN4 p.Thr377Ile Uncertain significance Single submitter
- STRN4 p.Thr391Ala Uncertain significance Single submitter
- STRN4 p.Thr408Asn Uncertain significance Single submitter
- STRN4 p.Thr599Asn Uncertain significance Single submitter
- STRN4 p.Thr628Met Uncertain significance Single submitter
- STRN4 p.Tyr181His Uncertain significance Single submitter
- STRN4 p.Val159Leu Uncertain significance Single submitter
- STRN4 p.Val199Ile Uncertain significance Single submitter
- STRN4 p.Val339Met Uncertain significance Single submitter
- STRN4 p.Val407Ile Uncertain significance Single submitter
- STRN4 p.Val535Leu Uncertain significance Single submitter
- STRN4 p.Val672Leu Uncertain significance Single submitter
- STRN4 p.Val714Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- STRN4 p.Ala38Asp Uncertain significance Single submitter
- STRN4 p.Ala403Ser Uncertain significance Single submitter
- STRN4 p.Ala91Val Uncertain significance Single submitter
- STRN4 p.Arg198His Uncertain significance Single submitter
- STRN4 p.Arg569Cys Uncertain significance Single submitter
- STRN4 p.Arg632Trp Uncertain significance Single submitter
- STRN4 p.Arg662His Uncertain significance Single submitter
- STRN4 p.Glu241Lys Uncertain significance Single submitter
- STRN4 p.Lys737Glu Uncertain significance Single submitter
- STRN4 p.Thr427Met Uncertain significance Single submitter
- STRN4 p.Tyr187His Uncertain significance Single submitter
- STRN4 p.Val199Phe Uncertain significance Single submitter
- STRN4 p.Val687Met Uncertain significance Single submitter
All STRN4 variants
Benign 3
- p.Pro158= Multiple submitters
- p.Met620Val Single submitter
- p.Thr628= Single submitter
Likely benign 6
- p.Val10= Multiple submitters
- c.282+64GCC[4] Single submitter
- p.Arg491= Single submitter
- p.Gly45= Single submitter
- p.Pro56= Single submitter
- p.Pro671Leu Single submitter
Uncertain significance 104
- c.1154-14T>G Single submitter
- c.1154-7T>C Single submitter
- c.1907-1G>T Single submitter
- c.737+1G>C Single submitter
- p.Ala11Val Single submitter ⚠
- p.Ala124Val Single submitter ⚠
- p.Ala14Gly Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala24Thr Single submitter ⚠
- p.Ala38Asp Single submitter ⚠
- p.Ala403Ser Single submitter ⚠
- p.Ala473Thr Single submitter ⚠
- p.Ala473Val Single submitter ⚠
- p.Ala478Val Single submitter ⚠
- p.Ala496Thr Single submitter ⚠
- p.Ala692Thr Single submitter ⚠
- p.Ala745Thr Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Ala84Val Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Ala9Glu Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg205Cys Single submitter ⚠
- p.Arg205Gly Single submitter ⚠
- p.Arg335Trp Single submitter ⚠
- p.Arg336Gln Single submitter ⚠
- p.Arg349Cys Single submitter ⚠
- p.Arg349His Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg381Trp Single submitter ⚠
- p.Arg558Cys Single submitter ⚠
- p.Arg569Cys Single submitter ⚠
- p.Arg632Gln Single submitter ⚠
- p.Arg632Trp Single submitter ⚠
- p.Arg662His Single submitter ⚠
- p.Arg85Cys Single submitter ⚠
- p.Asn156Ser Single submitter ⚠
- p.Asn476Ser Single submitter ⚠
- p.Asn476Tyr Single submitter ⚠
- p.Asp362Glu Single submitter ⚠
- p.Asp412Asn Single submitter ⚠
- p.Asp522Glu Single submitter ⚠
- p.Gln143fs Single submitter
- p.Gln143His Single submitter ⚠
- p.Gln639His Single submitter ⚠
- p.Gln642His Single submitter ⚠
- p.Gln715Arg Single submitter ⚠
- p.Glu145Gln Single submitter ⚠
- p.Glu217Asp Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu241Lys Single submitter ⚠
- p.Glu302Lys Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Glu602Lys Single submitter ⚠
- p.Glu61Ala Single submitter ⚠
- p.Gly27Ser Single submitter ⚠
- p.Gly591Arg Single submitter
- p.Gly633Asp Single submitter ⚠
- p.His485Arg Single submitter
- p.Ile392Val Single submitter ⚠
- p.Ile606Val Single submitter ⚠
- p.Leu360Val Single submitter ⚠
- p.Leu479Gln Single submitter
- p.Leu627Phe Single submitter ⚠
- p.Lys431Arg Single submitter ⚠
- p.Lys737Glu Single submitter ⚠
- p.Met2Leu Single submitter ⚠
- p.Met499Val Single submitter ⚠
- p.Met525Thr Single submitter ⚠
- p.Met525Val Single submitter ⚠
- p.Met620Thr Single submitter ⚠
- p.Pro19Gln Single submitter ⚠
- p.Pro301Ser Single submitter ⚠
- p.Pro367Ser Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Ser161Leu Single submitter ⚠
- p.Ser35Pro Single submitter ⚠
- p.Ser451Leu Single submitter ⚠
- p.Ser451Trp Single submitter
- p.Ser503Asn Single submitter
- p.Ser53Arg Single submitter ⚠
- p.Ser53Ile Single submitter ⚠
- p.Ser612Phe Single submitter
- p.Ser645Thr Single submitter ⚠
- p.Thr377Ile Single submitter ⚠
- p.Thr391Ala Single submitter ⚠
- p.Thr408Asn Single submitter ⚠
- p.Thr427Met Single submitter ⚠
- p.Thr599Asn Single submitter ⚠
- p.Thr628Met Single submitter ⚠
- p.Tyr181His Single submitter ⚠
- p.Tyr187His Single submitter ⚠
- p.Val159Leu Single submitter ⚠
- p.Val199Ile Single submitter ⚠
- p.Val199Phe Single submitter ⚠
- p.Val339Met Single submitter ⚠
- p.Val407Ile Single submitter ⚠
- p.Val535Leu Single submitter ⚠
- p.Val672Leu Single submitter ⚠
- p.Val687Met Single submitter ⚠
- p.Val714Met Single submitter ⚠