STX18 — 55 ClinVar variants
All ClinVar germline STX18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
1 Likely benign · 54 Uncertain significance
Full STX18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- STX18 p.Arg156Gly Uncertain significance Single submitter
- STX18 p.Arg203Cys Uncertain significance Single submitter
- STX18 p.Arg241Gln Uncertain significance Single submitter
- STX18 p.Arg35Gln Uncertain significance Single submitter
- STX18 p.Asn299Tyr Uncertain significance Single submitter
- STX18 p.Asp32Glu Uncertain significance Single submitter
- STX18 p.Asp331Asn Uncertain significance Single submitter
- STX18 p.Gln101Arg Uncertain significance Single submitter
- STX18 p.Gln237Leu Uncertain significance Single submitter
- STX18 p.Gln276Lys Uncertain significance Single submitter
- STX18 p.Gln286His Uncertain significance Single submitter
- STX18 p.Gln98Glu Uncertain significance Single submitter
- STX18 p.Glu129Gln Uncertain significance Single submitter
- STX18 p.Glu179Ala Uncertain significance Single submitter
- STX18 p.Glu196Gly Uncertain significance Single submitter
- STX18 p.Glu201Lys Uncertain significance Single submitter
- STX18 p.Gly221Asp Uncertain significance Single submitter
- STX18 p.Gly29Ser Uncertain significance Single submitter
- STX18 p.Gly47Ser Uncertain significance Single submitter
- STX18 p.His59Asp Uncertain significance Single submitter
- STX18 p.Ile243Met Uncertain significance Single submitter
- STX18 p.Leu227Phe Uncertain significance Single submitter
- STX18 p.Leu242Val Uncertain significance Single submitter
- STX18 p.Lys206Ile Uncertain significance Single submitter
- STX18 p.Met82Val Uncertain significance Single submitter
- STX18 p.Phe137Ile Uncertain significance Single submitter
- STX18 p.Phe250Ile Uncertain significance Single submitter
- STX18 p.Phe318Ser Uncertain significance Single submitter
- STX18 p.Pro229Ala Uncertain significance Single submitter
- STX18 p.Ser183Cys Uncertain significance Single submitter
- STX18 p.Ser51Asn Uncertain significance Single submitter
- STX18 p.Thr217Met Uncertain significance Single submitter
- STX18 p.Thr292Asn Uncertain significance Single submitter
- STX18 p.Thr91Ile Uncertain significance Single submitter
- STX18 p.Tyr85Cys Uncertain significance Single submitter
- STX18 p.Val134Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- STX18 p.Arg115Gln Uncertain significance Single submitter
- STX18 p.Arg41Trp Uncertain significance Single submitter
- STX18 p.Arg54Leu Uncertain significance Single submitter
- STX18 p.Asp331His Uncertain significance Single submitter
- STX18 p.Gly244Cys Uncertain significance Single submitter
- STX18 p.Gly24Arg Uncertain significance Single submitter
- STX18 p.Gly258Arg Uncertain significance Single submitter
- STX18 p.Ile138Thr Uncertain significance Single submitter
- STX18 p.Ile302Val Uncertain significance Single submitter
- STX18 p.Lys307Asn Uncertain significance Single submitter
- STX18 p.Lys72Glu Uncertain significance Single submitter
- STX18 p.Phe235Leu Uncertain significance Single submitter
- STX18 p.Ser124Tyr Uncertain significance Single submitter
- STX18 p.Thr18Lys Uncertain significance Single submitter
- STX18 p.Val157Leu Uncertain significance Single submitter
All STX18 variants
Likely benign 1
- p.Arg203His Single submitter
Uncertain significance 54
- p.Arg115Gln Single submitter ⚠
- p.Arg156Gly Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg52Trp Single submitter
- p.Arg54Leu Single submitter ⚠
- p.Asn299Tyr Single submitter ⚠
- p.Asp32Glu Single submitter ⚠
- p.Asp331Asn Single submitter ⚠
- p.Asp331His Single submitter ⚠
- p.Gln101Arg Single submitter ⚠
- p.Gln152Glu Single submitter
- p.Gln237Leu Single submitter ⚠
- p.Gln276Lys Single submitter ⚠
- p.Gln286His Single submitter ⚠
- p.Gln98Glu Single submitter ⚠
- p.Glu129Gln Single submitter ⚠
- p.Glu179Ala Single submitter ⚠
- p.Glu196Gly Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Gly221Asp Single submitter ⚠
- p.Gly244Cys Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Gly258Arg Single submitter ⚠
- p.Gly29Ser Single submitter ⚠
- p.Gly47Ser Single submitter ⚠
- p.His59Asp Single submitter ⚠
- p.Ile138Thr Single submitter ⚠
- p.Ile243Met Single submitter ⚠
- p.Ile302Val Single submitter ⚠
- p.Leu227Phe Single submitter ⚠
- p.Leu242Val Single submitter ⚠
- p.Lys206Ile Single submitter ⚠
- p.Lys307Asn Single submitter ⚠
- p.Lys72Glu Single submitter ⚠
- p.Met82Val Single submitter ⚠
- p.Phe137Ile Single submitter ⚠
- p.Phe235Leu Single submitter ⚠
- p.Phe250Ile Single submitter ⚠
- p.Phe318Ser Single submitter ⚠
- p.Pro229Ala Single submitter ⚠
- p.Ser124Tyr Single submitter ⚠
- p.Ser183Cys Single submitter ⚠
- p.Ser51Asn Single submitter ⚠
- p.Thr18Lys Single submitter ⚠
- p.Thr217Met Single submitter ⚠
- p.Thr292Asn Single submitter ⚠
- p.Thr91Ile Single submitter ⚠
- p.Tyr85Cys Single submitter ⚠
- p.Val134Ile Single submitter ⚠
- p.Val134Leu Single submitter
- p.Val157Leu Single submitter ⚠