SUCLG2 — 239 ClinVar variants
All ClinVar germline SUCLG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →
2 Conflicting · 20 Benign · 1 Benign/Likely benign · 54 Likely benign · 162 Uncertain significance
Full SUCLG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 140
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 119
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SUCLG2 p.Ala126Val Uncertain significance Multiple submitters
- SUCLG2 p.Ala17Ser Uncertain significance Multiple submitters
- SUCLG2 p.Ala17Thr Uncertain significance Multiple submitters
- SUCLG2 p.Ala181Val Uncertain significance Multiple submitters
- SUCLG2 p.Arg160Leu Uncertain significance Multiple submitters
-
SUCLG2 p.Asn361Ser
Uncertain significance
Multiple submitters
mitochondrial DNA depletion syndrome 9
- SUCLG2 p.Cys369Phe Uncertain significance Multiple submitters
- SUCLG2 p.Gln239Leu Uncertain significance Multiple submitters
- SUCLG2 p.Glu209Asp Uncertain significance Multiple submitters
- SUCLG2 p.Glu384Lys Uncertain significance Multiple submitters
- SUCLG2 p.Glu67Ala Uncertain significance Multiple submitters
- SUCLG2 p.Glu79Lys Uncertain significance Multiple submitters
- SUCLG2 p.Gly173Arg Uncertain significance Multiple submitters
- SUCLG2 p.Gly173Trp Uncertain significance Multiple submitters
- SUCLG2 p.Gly324Ser Uncertain significance Multiple submitters
- SUCLG2 p.Ile121Thr Uncertain significance Multiple submitters
- SUCLG2 p.Lys259Asn Uncertain significance Multiple submitters
- SUCLG2 p.Met141Ile Uncertain significance Multiple submitters
- SUCLG2 p.Pro185Leu Uncertain significance Multiple submitters
- SUCLG2 p.Pro388Ala Uncertain significance Multiple submitters
- SUCLG2 p.Pro388Leu Uncertain significance Multiple submitters
- SUCLG2 p.Pro4Leu Uncertain significance Multiple submitters
- SUCLG2 p.Ser98Arg Uncertain significance Multiple submitters
- SUCLG2 p.Tyr296Cys Uncertain significance Multiple submitters
- SUCLG2 p.Tyr43His Uncertain significance Multiple submitters
- SUCLG2 p.Val214Ala Uncertain significance Multiple submitters
- SUCLG2 p.Val214Ile Uncertain significance Multiple submitters
- SUCLG2 p.Ala155Thr Uncertain significance Single submitter
- SUCLG2 p.Ala17Val Uncertain significance Single submitter
- SUCLG2 p.Ala237Pro Uncertain significance Single submitter
- SUCLG2 p.Ala313Pro Uncertain significance Single submitter
- SUCLG2 p.Ala315Thr Uncertain significance Single submitter
- SUCLG2 p.Ala340Thr Uncertain significance Single submitter
- SUCLG2 p.Ala351Gly Uncertain significance Single submitter
- SUCLG2 p.Ala370Ser Uncertain significance Single submitter
- SUCLG2 p.Ala370Thr Uncertain significance Single submitter
- SUCLG2 p.Ala379Asp Uncertain significance Single submitter
- SUCLG2 p.Ala379Gly Uncertain significance Single submitter
- SUCLG2 p.Ala6Val Uncertain significance Single submitter
- SUCLG2 p.Ala84Val Uncertain significance Single submitter
- SUCLG2 p.Arg14Leu Uncertain significance Single submitter
- SUCLG2 p.Arg160Gln Uncertain significance Single submitter
- SUCLG2 p.Arg160Trp Uncertain significance Single submitter
- SUCLG2 p.Arg206Gln Uncertain significance Single submitter
- SUCLG2 p.Arg269Gln Uncertain significance Single submitter
- SUCLG2 p.Arg392Gln Uncertain significance Single submitter
- SUCLG2 p.Asn138Lys Uncertain significance Single submitter
- SUCLG2 p.Asn138Ser Uncertain significance Single submitter
- SUCLG2 p.Asn230Asp Uncertain significance Single submitter
- SUCLG2 p.Asn282Ser Uncertain significance Single submitter
- SUCLG2 p.Asn323His Uncertain significance Single submitter
- SUCLG2 p.Asn374His Uncertain significance Single submitter
- SUCLG2 p.Asn374Ser Uncertain significance Single submitter
- SUCLG2 p.Asp176Ala Uncertain significance Single submitter
- SUCLG2 p.Asp176Tyr Uncertain significance Single submitter
- SUCLG2 p.Asp201His Uncertain significance Single submitter
- SUCLG2 p.Asp236Val Uncertain significance Single submitter
- SUCLG2 p.Asp300Tyr Uncertain significance Single submitter
- SUCLG2 p.Asp352Asn Uncertain significance Single submitter
- SUCLG2 p.Cys162Phe Uncertain significance Single submitter
- SUCLG2 p.Cys305Ser Uncertain significance Single submitter
- SUCLG2 p.Cys305Tyr Uncertain significance Single submitter
- SUCLG2 p.Gln203Pro Uncertain significance Single submitter
- SUCLG2 p.Gln220Leu Uncertain significance Single submitter
- SUCLG2 p.Gln41Pro Uncertain significance Single submitter
- SUCLG2 p.Gln8Arg Uncertain significance Single submitter
- SUCLG2 p.Gln8Glu Uncertain significance Single submitter
- SUCLG2 p.Gln8His Uncertain significance Single submitter
- SUCLG2 p.Glu197Gln Uncertain significance Single submitter
- SUCLG2 p.Glu209Lys Uncertain significance Single submitter
- SUCLG2 p.Glu250Gly Uncertain significance Single submitter
- SUCLG2 p.Glu70Asp Uncertain significance Single submitter
- SUCLG2 p.Glu70Gln Uncertain significance Single submitter
- SUCLG2 p.Gly10Arg Uncertain significance Single submitter
- SUCLG2 p.Gly198Arg Uncertain significance Single submitter
- SUCLG2 p.Gly309Arg Uncertain significance Single submitter
- SUCLG2 p.Gly324Asp Uncertain significance Single submitter
- SUCLG2 p.Gly375Glu Uncertain significance Single submitter
- SUCLG2 p.Gly53Arg Uncertain significance Single submitter
- SUCLG2 p.Gly94Ala Uncertain significance Single submitter
- SUCLG2 p.Gly99Asp Uncertain significance Single submitter
- SUCLG2 p.Gly99Cys Uncertain significance Single submitter
- SUCLG2 p.Ile193Thr Uncertain significance Single submitter
- SUCLG2 p.Ile225Thr Uncertain significance Single submitter
- SUCLG2 p.Ile225Val Uncertain significance Single submitter
- SUCLG2 p.Ile273Val Uncertain significance Single submitter
- SUCLG2 p.Ile303Val Uncertain significance Single submitter
- SUCLG2 p.Ile366Val Uncertain significance Single submitter
- SUCLG2 p.Leu125Pro Uncertain significance Single submitter
- SUCLG2 p.Leu16Pro Uncertain significance Single submitter
- SUCLG2 p.Leu16Val Uncertain significance Single submitter
- SUCLG2 p.Leu231Arg Uncertain significance Single submitter
- SUCLG2 p.Leu294Val Uncertain significance Single submitter
- SUCLG2 p.Leu40Arg Uncertain significance Single submitter
- SUCLG2 p.Lys11Arg Uncertain significance Single submitter
- SUCLG2 p.Lys338Arg Uncertain significance Single submitter
- SUCLG2 p.Lys338Asn Uncertain significance Single submitter
- SUCLG2 p.Lys73Asn Uncertain significance Single submitter
- SUCLG2 p.Met120Val Uncertain significance Single submitter
- SUCLG2 p.Met158Thr Uncertain significance Single submitter
- SUCLG2 p.Met276Ile Uncertain significance Single submitter
- SUCLG2 p.Met314Val Uncertain significance Single submitter
- SUCLG2 p.Phe213Val Uncertain significance Single submitter
- SUCLG2 p.Phe268Leu Uncertain significance Single submitter
- SUCLG2 p.Ser149Phe Uncertain significance Single submitter
- SUCLG2 p.Ser149Tyr Uncertain significance Single submitter
- SUCLG2 p.Ser27Cys Uncertain significance Single submitter
- SUCLG2 p.Ser27Tyr Uncertain significance Single submitter
- SUCLG2 p.Thr226Ala Uncertain significance Single submitter
- SUCLG2 p.Thr226Met Uncertain significance Single submitter
- SUCLG2 p.Thr64Ile Uncertain significance Single submitter
- SUCLG2 p.Val140Gly Uncertain significance Single submitter
- SUCLG2 p.Val166Met Uncertain significance Single submitter
- SUCLG2 p.Val214Leu Uncertain significance Single submitter
- SUCLG2 p.Val253Ile Uncertain significance Single submitter
- SUCLG2 p.Val337Ile Uncertain significance Single submitter
- SUCLG2 p.Val355Phe Uncertain significance Single submitter
- SUCLG2 p.Val5Ile Uncertain significance Single submitter
- SUCLG2 p.Val5Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- SUCLG2 p.Ala357Gly Uncertain significance Multiple submitters
- SUCLG2 p.Arg381Trp Benign Multiple submitters
- SUCLG2 p.Glu70Lys Uncertain significance Multiple submitters
- SUCLG2 p.Ile320Thr Uncertain significance Multiple submitters
- SUCLG2 p.Ala9Asp Uncertain significance Single submitter
- SUCLG2 p.Arg206Trp Uncertain significance Single submitter
- SUCLG2 p.Asn124Asp Uncertain significance Single submitter
- SUCLG2 p.Asp278Asn Uncertain significance Single submitter
- SUCLG2 p.Glu394Ala Uncertain significance Single submitter
- SUCLG2 p.Leu333Phe Uncertain significance Single submitter
- SUCLG2 p.Leu349Phe Uncertain significance Single submitter
- SUCLG2 p.Lys108Glu Uncertain significance Single submitter
- SUCLG2 p.Lys132Glu Uncertain significance Single submitter
- SUCLG2 p.Lys386Glu Uncertain significance Single submitter
- SUCLG2 p.Pro284Arg Uncertain significance Single submitter
- SUCLG2 p.Ser3Tyr Uncertain significance Single submitter
- SUCLG2 p.Ser45Thr Uncertain significance Single submitter
- SUCLG2 p.Thr152Asn Uncertain significance Single submitter
- SUCLG2 p.Val240Met Uncertain significance Single submitter
All SUCLG2 variants
Conflicting classifications of pathogenicity 2
- p.Ala340Ser Single submitter ⚠
- p.Arg55Lys Single submitter ⚠
Benign 20
- c.327-18G>A Multiple submitters
- c.758-10_758-8del Multiple submitters
- c.85-20C>T Multiple submitters
- p.Ala117Thr Multiple submitters
- p.Arg381Trp Multiple submitters ⚠
- p.Leu211= Multiple submitters
- p.Lys347Arg Multiple submitters
- p.Tyr404His Multiple submitters
- p.Val425Ile Multiple submitters
- c.1063-8G>C Single submitter
- c.1183+20C>T Single submitter
- c.326+10G>C Single submitter
- c.418-12C>T Single submitter
- c.660+13T>C Single submitter
- c.757+14del Single submitter
- c.757+14dup Single submitter
- p.Leu116= Single submitter
- p.Leu16= Single submitter
- c.1184-7C>T No assertion criteria SUCLG2-related disorder
- p.Thr396Ala No assertion criteria SUCLG2-related disorder
Benign/Likely benign 1
- p.Lys101Arg Multiple submitters
Likely benign 54
- p.Gly174= Multiple submitters
- c.1062+10_1062+15del Single submitter
- c.226+13A>G Single submitter
- c.227-16G>A Single submitter
- c.227-17G>T Single submitter
- c.327-5C>G Single submitter
- c.417+10A>G Single submitter
- c.417+7T>C Single submitter
- c.418-20C>A Single submitter
- c.570+14C>T Single submitter
- c.570+16G>A Single submitter
- c.570+17G>C Single submitter
- c.660+7A>G Single submitter
- c.757+14A>G Single submitter
- c.757+16A>G Single submitter
- c.757+17del Single submitter
- c.758-14T>C Single submitter
- c.758-18del Single submitter
- c.84+12G>A Single submitter
- c.84+13G>T Single submitter
- c.84+8T>C Single submitter
- c.85-12C>T Single submitter
- c.85-15C>T Single submitter
- c.85-4G>A Single submitter
- c.919+15T>C Single submitter
- c.919+7A>G Single submitter
- c.920-12T>C Single submitter
- c.920-15A>T Single submitter
- p.Ala182= Single submitter
- p.Ala208= Single submitter
- p.Ala9= Single submitter
- p.Arg19= Single submitter
- p.Arg21= Single submitter
- p.Arg381Gln Single submitter
- p.Asn265= Single submitter
- p.Gln44= Single submitter
- p.Gln8= Single submitter
- p.Glu384= Single submitter
- p.Gly122= Single submitter
- p.Gly164= Single submitter
- p.Gly215= Single submitter
- p.Ile195= Single submitter
- p.Ile319= Single submitter
- p.Ile366= Single submitter
- p.Leu13= Single submitter
- p.Leu69= Single submitter
- p.Lys279= Single submitter
- p.Lys347= Single submitter
- p.Phe213= Single submitter
- p.Phe22Leu Single submitter
- p.Pro165= Single submitter
- p.Ser161= Single submitter
- p.Thr226= Single submitter
- c.1184-10C>T No assertion criteria SUCLG2-related disorder
Uncertain significance 162
- p.Ala126Val Multiple submitters ⚠
- p.Ala17Ser Multiple submitters ⚠
- p.Ala17Thr Multiple submitters ⚠
- p.Ala181Val Multiple submitters ⚠
- p.Ala357Gly Multiple submitters ⚠
- p.Arg160Leu Multiple submitters ⚠
- p.Asn361Ser Multiple submitters mitochondrial DNA depletion syndrome 9 ⚠
- p.Asn415Lys Multiple submitters
- p.Cys369Phe Multiple submitters ⚠
- p.Gln239Leu Multiple submitters ⚠
- p.Glu209Asp Multiple submitters ⚠
- p.Glu384Lys Multiple submitters ⚠
- p.Glu67Ala Multiple submitters ⚠
- p.Glu70Lys Multiple submitters ⚠
- p.Glu79Lys Multiple submitters ⚠
- p.Gly173Arg Multiple submitters ⚠
- p.Gly173Trp Multiple submitters ⚠
- p.Gly324Ser Multiple submitters ⚠
- p.Ile121Thr Multiple submitters ⚠
- p.Ile320Thr Multiple submitters ⚠
- p.Lys108Asn Multiple submitters
- p.Lys259Asn Multiple submitters ⚠
- p.Met141Ile Multiple submitters ⚠
- p.Pro185Leu Multiple submitters ⚠
- p.Pro388Ala Multiple submitters ⚠
- p.Pro388Leu Multiple submitters ⚠
- p.Pro4Leu Multiple submitters ⚠
- p.Ser98Arg Multiple submitters ⚠
- p.Tyr296Cys Multiple submitters ⚠
- p.Tyr43His Multiple submitters ⚠
- p.Val214Ala Multiple submitters ⚠
- p.Val214Ile Multiple submitters ⚠
- p.Val367Ile Multiple submitters
- c.1062+5C>T Single submitter
- c.226+6C>G Single submitter
- p.Ala155Thr Single submitter ⚠
- p.Ala17Val Single submitter ⚠
- p.Ala204Thr Single submitter
- p.Ala237Pro Single submitter ⚠
- p.Ala2Val Single submitter
- p.Ala313Pro Single submitter ⚠
- p.Ala315Thr Single submitter ⚠
- p.Ala340Thr Single submitter ⚠
- p.Ala351Gly Single submitter ⚠
- p.Ala370Ser Single submitter ⚠
- p.Ala370Thr Single submitter ⚠
- p.Ala379Asp Single submitter ⚠
- p.Ala379Gly Single submitter ⚠
- p.Ala62Gly Single submitter
- p.Ala6Val Single submitter ⚠
- p.Ala84Val Single submitter ⚠
- p.Ala9Asp Single submitter ⚠
- p.Arg14Leu Single submitter ⚠
- p.Arg150Ter Single submitter
- p.Arg160Gln Single submitter ⚠
- p.Arg160Trp Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg206Trp Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Arg269Ter Single submitter
- p.Arg392Gln Single submitter ⚠
- p.Asn124Asp Single submitter ⚠
- p.Asn138Lys Single submitter ⚠
- p.Asn138Ser Single submitter ⚠
- p.Asn230Asp Single submitter ⚠
- p.Asn282Ser Single submitter ⚠
- p.Asn323His Single submitter ⚠
- p.Asn374His Single submitter ⚠
- p.Asn374Ser Single submitter ⚠
- p.Asp176Ala Single submitter ⚠
- p.Asp176Tyr Single submitter ⚠
- p.Asp201His Single submitter ⚠
- p.Asp236Val Single submitter ⚠
- p.Asp264Asn Single submitter
- p.Asp278Asn Single submitter ⚠
- p.Asp300Tyr Single submitter ⚠
- p.Asp352Asn Single submitter ⚠
- p.Cys162Phe Single submitter ⚠
- p.Cys305Ser Single submitter ⚠
- p.Cys305Tyr Single submitter ⚠
- p.Gln203Pro Single submitter ⚠
- p.Gln220Leu Single submitter ⚠
- p.Gln41Pro Single submitter ⚠
- p.Gln41Ter Single submitter
- p.Gln8Arg Single submitter ⚠
- p.Gln8Glu Single submitter ⚠
- p.Gln8His Single submitter ⚠
- p.Glu197Gln Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Glu250Gly Single submitter ⚠
- p.Glu283Lys Single submitter
- p.Glu394Ala Single submitter ⚠
- p.Glu70Asp Single submitter ⚠
- p.Glu70Gln Single submitter ⚠
- p.Gly103del Single submitter
- p.Gly10Arg Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly309Arg Single submitter ⚠
- p.Gly324Asp Single submitter ⚠
- p.Gly335fs Single submitter
- p.Gly375Glu Single submitter ⚠
- p.Gly375Lys Single submitter
- p.Gly402fs Single submitter
- p.Gly53Arg Single submitter ⚠
- p.Gly89fs Single submitter
- p.Gly94Ala Single submitter ⚠
- p.Gly99Asp Single submitter ⚠
- p.Gly99Cys Single submitter ⚠
- p.His105Gln Single submitter
- p.Ile193Thr Single submitter ⚠
- p.Ile225Thr Single submitter ⚠
- p.Ile225Val Single submitter ⚠
- p.Ile273Val Single submitter ⚠
- p.Ile303Val Single submitter ⚠
- p.Ile366Val Single submitter ⚠
- p.Leu125Pro Single submitter ⚠
- p.Leu16Pro Single submitter ⚠
- p.Leu16Val Single submitter ⚠
- p.Leu231Arg Single submitter ⚠
- p.Leu294Val Single submitter ⚠
- p.Leu333Phe Single submitter ⚠
- p.Leu349Phe Single submitter ⚠
- p.Leu389fs Single submitter
- p.Leu40Arg Single submitter ⚠
- p.Leu439fs Single submitter
- p.Lys108Glu Single submitter ⚠
- p.Lys11Arg Single submitter ⚠
- p.Lys132Glu Single submitter ⚠
- p.Lys279_Ser280insTer Single submitter
- p.Lys338Arg Single submitter ⚠
- p.Lys338Asn Single submitter ⚠
- p.Lys386Glu Single submitter ⚠
- p.Lys73Asn Single submitter ⚠
- p.Met120Val Single submitter ⚠
- p.Met158Thr Single submitter ⚠
- p.Met276Ile Single submitter ⚠
- p.Met314Val Single submitter ⚠
- p.Phe213Val Single submitter ⚠
- p.Phe268Leu Single submitter ⚠
- p.Pro284Arg Single submitter ⚠
- p.Ser149Phe Single submitter ⚠
- p.Ser149Tyr Single submitter ⚠
- p.Ser27Cys Single submitter ⚠
- p.Ser27Tyr Single submitter ⚠
- p.Ser3Tyr Single submitter ⚠
- p.Ser45Thr Single submitter ⚠
- p.Thr152Asn Single submitter ⚠
- p.Thr226Ala Single submitter ⚠
- p.Thr226Met Single submitter ⚠
- p.Thr64Ile Single submitter ⚠
- p.Val140Gly Single submitter ⚠
- p.Val166fs Single submitter
- p.Val166Met Single submitter ⚠
- p.Val175fs Single submitter
- p.Val180fs Single submitter
- p.Val214Leu Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val253Ile Single submitter ⚠
- p.Val337Ile Single submitter ⚠
- p.Val355Phe Single submitter ⚠
- p.Val5Ile Single submitter ⚠
- p.Val5Leu Single submitter ⚠