SUDS3 — 26 ClinVar variants
All ClinVar germline SUDS3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Benign/Likely benign · 1 Likely benign · 24 Uncertain significance
Full SUDS3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SUDS3 p.Ala19Val Uncertain significance Single submitter
- SUDS3 p.Ala246Val Uncertain significance Single submitter
- SUDS3 p.Ala250Thr Uncertain significance Single submitter
- SUDS3 p.Asn295Ser Uncertain significance Single submitter
- SUDS3 p.Gln83His Uncertain significance Single submitter
- SUDS3 p.Glu114Asp Uncertain significance Single submitter
- SUDS3 p.Glu21Asp Uncertain significance Single submitter
- SUDS3 p.Glu31Asp Uncertain significance Single submitter
- SUDS3 p.Leu102Pro Uncertain significance Single submitter
- SUDS3 p.Leu84Phe Uncertain significance Single submitter
- SUDS3 p.Lys261Arg Uncertain significance Single submitter
- SUDS3 p.Phe139Ser Uncertain significance Single submitter
- SUDS3 p.Pro20Leu Uncertain significance Single submitter
- SUDS3 p.Pro232Leu Uncertain significance Single submitter
- SUDS3 p.Pro235Ala Uncertain significance Single submitter
- SUDS3 p.Ser32Asn Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SUDS3 p.Asp46Gly Uncertain significance Single submitter
- SUDS3 p.Asp51Tyr Uncertain significance Single submitter
- SUDS3 p.Gln251Arg Uncertain significance Single submitter
- SUDS3 p.Ile129Ser Uncertain significance Single submitter
- SUDS3 p.Ile151Thr Uncertain significance Single submitter
- SUDS3 p.Met72Leu Uncertain significance Single submitter
- SUDS3 p.Trp298Cys Uncertain significance Single submitter
- SUDS3 p.Val292Leu Uncertain significance Single submitter
All SUDS3 variants
Benign/Likely benign 1
- p.Arg317= Multiple submitters
Likely benign 1
- p.Ala3= Single submitter
Uncertain significance 24
- p.Ala19Val Single submitter ⚠
- p.Ala246Val Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asp46Gly Single submitter ⚠
- p.Asp51Tyr Single submitter ⚠
- p.Gln251Arg Single submitter ⚠
- p.Gln83His Single submitter ⚠
- p.Glu114Asp Single submitter ⚠
- p.Glu21Asp Single submitter ⚠
- p.Glu31Asp Single submitter ⚠
- p.Ile129Ser Single submitter ⚠
- p.Ile151Thr Single submitter ⚠
- p.Leu102Pro Single submitter ⚠
- p.Leu84Phe Single submitter ⚠
- p.Lys261Arg Single submitter ⚠
- p.Met72Leu Single submitter ⚠
- p.Phe139Ser Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro232Leu Single submitter ⚠
- p.Pro235Ala Single submitter ⚠
- p.Ser32Asn Single submitter ⚠
- p.Trp298Cys Single submitter ⚠
- p.Val292Leu Single submitter ⚠