SUGT1 — 38 ClinVar variants
All ClinVar germline SUGT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
4 Likely benign · 34 Uncertain significance
Full SUGT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SUGT1 p.Ala111Val Uncertain significance Single submitter
- SUGT1 p.Ala29Val Uncertain significance Single submitter
- SUGT1 p.Ala3Val Uncertain significance Single submitter
- SUGT1 p.Ala9Val Uncertain significance Single submitter
- SUGT1 p.Asp26Asn Uncertain significance Single submitter
- SUGT1 p.Asp287Asn Uncertain significance Single submitter
- SUGT1 p.Asp290Val Uncertain significance Single submitter
- SUGT1 p.Cys49Gly Uncertain significance Single submitter
- SUGT1 p.Gln123Leu Uncertain significance Single submitter
- SUGT1 p.Gln12Arg Uncertain significance Single submitter
- SUGT1 p.Gln16His Uncertain significance Single submitter
- SUGT1 p.Glu329Gly Uncertain significance Single submitter
- SUGT1 p.Ile23Leu Uncertain significance Single submitter
- SUGT1 p.Leu57Val Uncertain significance Single submitter
- SUGT1 p.Lys242Arg Uncertain significance Single submitter
- SUGT1 p.Met82Thr Uncertain significance Single submitter
- SUGT1 p.Phe15Leu Uncertain significance Single submitter
- SUGT1 p.Phe18Cys Uncertain significance Single submitter
- SUGT1 p.Pro324Thr Uncertain significance Single submitter
- SUGT1 p.Ser313Thr Uncertain significance Single submitter
- SUGT1 p.Thr252Ile Uncertain significance Single submitter
- SUGT1 p.Thr35Ile Uncertain significance Single submitter
- SUGT1 p.Tyr95Asp Uncertain significance Single submitter
- SUGT1 p.Val133Leu Uncertain significance Single submitter
- SUGT1 p.Val165Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SUGT1 p.Ala2Val Uncertain significance Single submitter
- SUGT1 p.Arg121Thr Uncertain significance Single submitter
- SUGT1 p.Asn268Tyr Uncertain significance Single submitter
- SUGT1 p.Asp314Ala Uncertain significance Single submitter
- SUGT1 p.His91Pro Uncertain significance Single submitter
- SUGT1 p.Ile210Met Uncertain significance Single submitter
- SUGT1 p.Met156Ile Uncertain significance Single submitter
- SUGT1 p.Met328Thr Uncertain significance Single submitter
All SUGT1 variants
Likely benign 4
- p.Arg13= Single submitter
- p.Leu22= Single submitter
- p.Lys141= Single submitter
- c.329-1102A>C No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 34
- p.Ala111Val Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg121Thr Single submitter ⚠
- p.Asn268Tyr Single submitter ⚠
- p.Asn311Ser Single submitter
- p.Asp26Asn Single submitter ⚠
- p.Asp287Asn Single submitter ⚠
- p.Asp290Val Single submitter ⚠
- p.Asp314Ala Single submitter ⚠
- p.Cys49Gly Single submitter ⚠
- p.Gln123Leu Single submitter ⚠
- p.Gln12Arg Single submitter ⚠
- p.Gln16His Single submitter ⚠
- p.Glu329Gly Single submitter ⚠
- p.His91Pro Single submitter ⚠
- p.Ile210Met Single submitter ⚠
- p.Ile23Leu Single submitter ⚠
- p.Leu57Val Single submitter ⚠
- p.Lys242Arg Single submitter ⚠
- p.Met156Ile Single submitter ⚠
- p.Met328Thr Single submitter ⚠
- p.Met82Thr Single submitter ⚠
- p.Phe15Leu Single submitter ⚠
- p.Phe18Cys Single submitter ⚠
- p.Pro324Thr Single submitter ⚠
- p.Ser313Thr Single submitter ⚠
- p.Thr252Ile Single submitter ⚠
- p.Thr35Ile Single submitter ⚠
- p.Tyr95Asp Single submitter ⚠
- p.Val133Leu Single submitter ⚠
- p.Val165Leu Single submitter ⚠