SYNRG — 156 ClinVar variants
All ClinVar germline SYNRG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 129 flagged for review →
1 Benign · 20 Likely benign · 135 Uncertain significance
Full SYNRG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 129
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 107
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SYNRG p.Ala15Thr Uncertain significance Single submitter
- SYNRG p.Ala17Val Uncertain significance Single submitter
- SYNRG p.Ala261Thr Uncertain significance Single submitter
- SYNRG p.Ala2Ser Uncertain significance Single submitter
- SYNRG p.Ala382Thr Uncertain significance Single submitter
- SYNRG p.Ala507Thr Uncertain significance Single submitter
- SYNRG p.Ala522Val Uncertain significance Single submitter
- SYNRG p.Ala559Gly Uncertain significance Single submitter
- SYNRG p.Ala635Pro Uncertain significance Single submitter
- SYNRG p.Ala660Val Uncertain significance Single submitter
- SYNRG p.Ala81Gly Uncertain significance Single submitter
- SYNRG p.Arg1083Cys Uncertain significance Single submitter
- SYNRG p.Arg1259Gln Uncertain significance Single submitter
- SYNRG p.Arg1259Trp Uncertain significance Single submitter
- SYNRG p.Arg126Gln Uncertain significance Single submitter
- SYNRG p.Arg344Gln Uncertain significance Single submitter
- SYNRG p.Asn1099His Uncertain significance Single submitter
- SYNRG p.Asn1226Lys Uncertain significance Single submitter
- SYNRG p.Asn295Ser Uncertain significance Single submitter
- SYNRG p.Asn378Ile Uncertain significance Single submitter
- SYNRG p.Asp1206Asn Uncertain significance Single submitter
- SYNRG p.Asp317His Uncertain significance Single submitter
- SYNRG p.Asp577Asn Uncertain significance Single submitter
- SYNRG p.Asp577Val Uncertain significance Single submitter
- SYNRG p.Asp710Tyr Uncertain significance Single submitter
- SYNRG p.Cys208Ser Uncertain significance Single submitter
- SYNRG p.Gln1092His Uncertain significance Single submitter
- SYNRG p.Gln1166Glu Uncertain significance Single submitter
- SYNRG p.Gln379His Uncertain significance Single submitter
- SYNRG p.Glu1185Gln Uncertain significance Single submitter
- SYNRG p.Glu260Gly Uncertain significance Single submitter
- SYNRG p.Glu273Lys Uncertain significance Single submitter
- SYNRG p.Glu544Lys Uncertain significance Single submitter
- SYNRG p.Glu628Asp Uncertain significance Single submitter
- SYNRG p.Glu795Gln Uncertain significance Single submitter
- SYNRG p.Glu795Lys Uncertain significance Single submitter
- SYNRG p.Gly1214Ser Uncertain significance Single submitter
- SYNRG p.Gly23Ala Uncertain significance Single submitter
- SYNRG p.Gly23Val Uncertain significance Single submitter
- SYNRG p.Gly368Cys Uncertain significance Single submitter
- SYNRG p.Gly408Ser Uncertain significance Single submitter
- SYNRG p.Gly519Val Uncertain significance Single submitter
- SYNRG p.Gly6Val Uncertain significance Single submitter
- SYNRG p.Gly759Ser Uncertain significance Single submitter
- SYNRG p.Ile210Thr Uncertain significance Single submitter
- SYNRG p.Ile271Val Uncertain significance Single submitter
- SYNRG p.Ile405Leu Uncertain significance Single submitter
- SYNRG p.Ile405Thr Uncertain significance Single submitter
- SYNRG p.Ile442Leu Uncertain significance Single submitter
- SYNRG p.Ile442Val Uncertain significance Single submitter
- SYNRG p.Ile600Leu Uncertain significance Single submitter
- SYNRG p.Ile600Val Uncertain significance Single submitter
- SYNRG p.Leu230Val Uncertain significance Single submitter
- SYNRG p.Leu269Val Uncertain significance Single submitter
- SYNRG p.Lys1079Arg Uncertain significance Single submitter
- SYNRG p.Lys1143Glu Uncertain significance Single submitter
- SYNRG p.Lys1240Glu Uncertain significance Single submitter
- SYNRG p.Lys228Glu Uncertain significance Single submitter
- SYNRG p.Lys552Arg Uncertain significance Single submitter
- SYNRG p.Lys662Glu Uncertain significance Single submitter
- SYNRG p.Met45Arg Uncertain significance Single submitter
- SYNRG p.Met45Thr Uncertain significance Single submitter
- SYNRG p.Met52Leu Uncertain significance Single submitter
- SYNRG p.Met56Val Uncertain significance Single submitter
- SYNRG p.Met88Val Uncertain significance Single submitter
-
SYNRG p.Phe1094Val
Uncertain significance
Single submitter
SYNRG-related disorder
- SYNRG p.Pro1088Ser Uncertain significance Single submitter
- SYNRG p.Pro193Ser Uncertain significance Single submitter
- SYNRG p.Pro37Thr Uncertain significance Single submitter
- SYNRG p.Pro398Leu Uncertain significance Single submitter
- SYNRG p.Pro406Leu Uncertain significance Single submitter
- SYNRG p.Pro414Leu Uncertain significance Single submitter
- SYNRG p.Pro481Ala Uncertain significance Single submitter
- SYNRG p.Pro481Leu Uncertain significance Single submitter
- SYNRG p.Pro501Ser Uncertain significance Single submitter
- SYNRG p.Pro553Arg Uncertain significance Single submitter
- SYNRG p.Pro584Ala Uncertain significance Single submitter
- SYNRG p.Pro5Ala Uncertain significance Single submitter
- SYNRG p.Pro768Ser Uncertain significance Single submitter
- SYNRG p.Ser211Asn Uncertain significance Single submitter
- SYNRG p.Ser274Asn Uncertain significance Single submitter
- SYNRG p.Ser392Cys Uncertain significance Single submitter
- SYNRG p.Ser557Thr Uncertain significance Single submitter
- SYNRG p.Ser622Thr Uncertain significance Single submitter
- SYNRG p.Ser626Asn Uncertain significance Single submitter
- SYNRG p.Ser638Asn Uncertain significance Single submitter
- SYNRG p.Ser665Ile Uncertain significance Single submitter
- SYNRG p.Ser73Pro Uncertain significance Single submitter
- SYNRG p.Thr212Ile Uncertain significance Single submitter
- SYNRG p.Thr345Ser Uncertain significance Single submitter
- SYNRG p.Thr599Pro Uncertain significance Single submitter
- SYNRG p.Thr661Ile Uncertain significance Single submitter
- SYNRG p.Thr767Ser Uncertain significance Single submitter
- SYNRG p.Val1109Ile Uncertain significance Single submitter
- SYNRG p.Val1208Ile Uncertain significance Single submitter
- SYNRG p.Val206Leu Uncertain significance Single submitter
- SYNRG p.Val299Leu Uncertain significance Single submitter
- SYNRG p.Val31Ile Uncertain significance Single submitter
- SYNRG p.Val358Ile Uncertain significance Single submitter
- SYNRG p.Val369Ile Uncertain significance Single submitter
- SYNRG p.Val421Ala Uncertain significance Single submitter
- SYNRG p.Val450Ile Uncertain significance Single submitter
- SYNRG p.Val685Ala Uncertain significance Single submitter
- SYNRG p.Val732Met Uncertain significance Single submitter
- SYNRG p.Val834Leu Uncertain significance Single submitter
- SYNRG p.Val861Leu Uncertain significance Single submitter
- SYNRG p.Leu1202Pro Uncertain significance No assertion criteria
Predictors split 22
The independent predictors disagree with each other — read with care.
- SYNRG p.Ala1246Val Uncertain significance Single submitter
- SYNRG p.Ala1291Thr Uncertain significance Single submitter
- SYNRG p.Ala171Val Uncertain significance Single submitter
- SYNRG p.Arg1111Pro Uncertain significance Single submitter
- SYNRG p.Arg1257Thr Uncertain significance Single submitter
- SYNRG p.Asp456Ala Uncertain significance Single submitter
- SYNRG p.Glu829Lys Uncertain significance Single submitter
- SYNRG p.Gly11Asp Uncertain significance Single submitter
- SYNRG p.Gly13Arg Uncertain significance Single submitter
- SYNRG p.Gly23Glu Uncertain significance Single submitter
- SYNRG p.Gly75Arg Uncertain significance Single submitter
- SYNRG p.Leu153Ser Uncertain significance Single submitter
- SYNRG p.Leu359Val Uncertain significance Single submitter
- SYNRG p.Lys518Glu Uncertain significance Single submitter
- SYNRG p.Met1216Val Uncertain significance Single submitter
- SYNRG p.Pro859Gln Uncertain significance Single submitter
- SYNRG p.Ser154Gly Uncertain significance Single submitter
- SYNRG p.Val1249Met Uncertain significance Single submitter
- SYNRG p.Val299Ala Uncertain significance Single submitter
-
SYNRG p.Asp182Asn
Likely benign
No assertion criteria
SYNRG-related disorder
-
SYNRG p.Asp572Glu
Uncertain significance
No assertion criteria
SYNRG-related disorder
-
SYNRG p.Gly49Arg
Uncertain significance
No assertion criteria
SYNRG-related disorder
All SYNRG variants
Benign 1
- p.Pro962= No assertion criteria SYNRG-related disorder
Likely benign 20
- c.3777+3A>G Single submitter
- p.Asp534Glu Single submitter
- p.Gly26Ser Single submitter
- p.Ile385Val Single submitter
- p.Ile405Met Single submitter
- p.Ile702Val Single submitter
- p.Ile787Met Single submitter
- p.Phe204Leu Single submitter
- p.Pro593Ala Single submitter
- p.Thr599Ala Single submitter
- p.Thr639= Single submitter
- p.Val636Ala Single submitter
- p.Val728Met Single submitter
- c.3518-6C>T No assertion criteria SYNRG-related disorder
- p.Asp182Asn No assertion criteria SYNRG-related disorder ⚠
- p.Ile1213= No assertion criteria SYNRG-related disorder
- p.Lys1104= No assertion criteria SYNRG-related disorder
- p.Phe204= No assertion criteria SYNRG-related disorder
- p.Pro406Thr No assertion criteria SYNRG-related disorder
- p.Val1193= No assertion criteria SYNRG-related disorder
Uncertain significance 135
- c.372-1G>A Single submitter SYNRG-related disorder
- c.3813+5G>A Single submitter
- p.Ala1246Val Single submitter ⚠
- p.Ala1291Thr Single submitter ⚠
- p.Ala15Thr Single submitter ⚠
- p.Ala171Val Single submitter ⚠
- p.Ala17Val Single submitter ⚠
- p.Ala261Thr Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Ala382Thr Single submitter ⚠
- p.Ala507Thr Single submitter ⚠
- p.Ala522Val Single submitter ⚠
- p.Ala559Gly Single submitter ⚠
- p.Ala635Pro Single submitter ⚠
- p.Ala660Val Single submitter ⚠
- p.Ala81Gly Single submitter ⚠
- p.Arg1083Cys Single submitter ⚠
- p.Arg1111Pro Single submitter ⚠
- p.Arg1257Thr Single submitter ⚠
- p.Arg1259Gln Single submitter ⚠
- p.Arg1259Trp Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg344Gln Single submitter ⚠
- p.Asn1099His Single submitter ⚠
- p.Asn1226Lys Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn378Ile Single submitter ⚠
- p.Asp1206Asn Single submitter ⚠
- p.Asp1224Gly Single submitter
- p.Asp317His Single submitter ⚠
- p.Asp456Ala Single submitter ⚠
- p.Asp567Tyr Single submitter
- p.Asp577Asn Single submitter ⚠
- p.Asp577Val Single submitter ⚠
- p.Asp710Tyr Single submitter ⚠
- p.Cys208Ser Single submitter ⚠
- p.Gln1092His Single submitter ⚠
- p.Gln1166Glu Single submitter ⚠
- p.Gln379His Single submitter ⚠
- p.Glu1185Gln Single submitter ⚠
- p.Glu260Gly Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Glu544Lys Single submitter ⚠
- p.Glu628Asp Single submitter ⚠
- p.Glu795Gln Single submitter ⚠
- p.Glu795Lys Single submitter ⚠
- p.Glu829Lys Single submitter ⚠
- p.Gly11Asp Single submitter ⚠
- p.Gly1214Ser Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly23Ala Single submitter ⚠
- p.Gly23Glu Single submitter ⚠
- p.Gly23Val Single submitter ⚠
- p.Gly368Cys Single submitter ⚠
- p.Gly408Ser Single submitter ⚠
- p.Gly468Arg Single submitter
- p.Gly519Val Single submitter ⚠
- p.Gly6Val Single submitter ⚠
- p.Gly759Ser Single submitter ⚠
- p.Gly75Arg Single submitter ⚠
- p.Ile210Thr Single submitter ⚠
- p.Ile271Val Single submitter ⚠
- p.Ile405Leu Single submitter ⚠
- p.Ile405Thr Single submitter ⚠
- p.Ile442Leu Single submitter ⚠
- p.Ile442Val Single submitter ⚠
- p.Ile600Leu Single submitter ⚠
- p.Ile600Val Single submitter ⚠
- p.Leu153Ser Single submitter ⚠
- p.Leu230Val Single submitter ⚠
- p.Leu269Val Single submitter ⚠
- p.Leu359Val Single submitter ⚠
- p.Lys1079Arg Single submitter ⚠
- p.Lys1143Glu Single submitter ⚠
- p.Lys1240Glu Single submitter ⚠
- p.Lys228Glu Single submitter ⚠
- p.Lys518Glu Single submitter ⚠
- p.Lys552Arg Single submitter ⚠
- p.Lys662Glu Single submitter ⚠
- p.Met1216Val Single submitter ⚠
- p.Met45Arg Single submitter ⚠
- p.Met45Thr Single submitter ⚠
- p.Met52Leu Single submitter ⚠
- p.Met56Val Single submitter ⚠
- p.Met88Val Single submitter ⚠
- p.Phe1094Val Single submitter SYNRG-related disorder ⚠
- p.Pro1088Ser Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro37Thr Single submitter ⚠
- p.Pro398Leu Single submitter ⚠
- p.Pro406Leu Single submitter ⚠
- p.Pro414Leu Single submitter ⚠
- p.Pro481Ala Single submitter ⚠
- p.Pro481Leu Single submitter ⚠
- p.Pro501Ser Single submitter ⚠
- p.Pro553Arg Single submitter ⚠
- p.Pro584Ala Single submitter ⚠
- p.Pro5Ala Single submitter ⚠
- p.Pro768Ser Single submitter ⚠
- p.Pro859Gln Single submitter ⚠
- p.Pro867Leu Single submitter
- p.Ser154Gly Single submitter ⚠
- p.Ser211Asn Single submitter ⚠
- p.Ser274Asn Single submitter ⚠
- p.Ser392Cys Single submitter ⚠
- p.Ser557Thr Single submitter ⚠
- p.Ser622Thr Single submitter ⚠
- p.Ser626Asn Single submitter ⚠
- p.Ser638Asn Single submitter ⚠
- p.Ser665Ile Single submitter ⚠
- p.Ser73Pro Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Thr345Ser Single submitter ⚠
- p.Thr599Pro Single submitter ⚠
- p.Thr661Ile Single submitter ⚠
- p.Thr767Ser Single submitter ⚠
- p.Val1109Ile Single submitter ⚠
- p.Val1208Ile Single submitter ⚠
- p.Val1249Met Single submitter ⚠
- p.Val206Leu Single submitter ⚠
- p.Val299Ala Single submitter ⚠
- p.Val299Leu Single submitter ⚠
- p.Val31Ile Single submitter ⚠
- p.Val358Ile Single submitter ⚠
- p.Val369Ile Single submitter ⚠
- p.Val421Ala Single submitter ⚠
- p.Val450Ile Single submitter ⚠
- p.Val685Ala Single submitter ⚠
- p.Val732Met Single submitter ⚠
- p.Val834Leu Single submitter ⚠
- p.Val861Leu Single submitter ⚠
- p.Asp572Glu No assertion criteria SYNRG-related disorder ⚠
- p.Glu1080Lys No assertion criteria SYNRG-related disorder
- p.Gly49Arg No assertion criteria SYNRG-related disorder ⚠
- p.Leu1202Pro No assertion criteria ⚠